Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model.
2019Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
supportedmidmoderate inflation risk
Flavonifractor plautii
colorectal cancer
Flavonifractor plautii is an interesting but still moderate-confidence signal in colorectal cancer.
Flavonifractor plautii shows a moderate evidence base in colorectal cancer, with multiple central papers and additional supporting literature.
flavonifractor_plautii
Credibility score
37
Human translation
5/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 37Human translation 5/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
Main caveats
- directionality and confounding still require curated review
Primary central evidence
14 papersGut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation.
2019BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of Flavonifractor plautii, a Flavonoid-Degrading Bacterium, with the Gut Microbiome of Colorectal Cancer Patients in India.
2019mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Screening of Human Gut Bacterial Culture Collection Identifies Species That Biotransform Quercetin into Metabolites with Anticancer Properties.
2021International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of human gut microbiome in young-onset colorectal cancer.
2021Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exome and Tissue-Associated Microbiota as Predictive Markers of Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer.
2022Frontiers in oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer.
2023Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of distinct microbial signatures with premalignant colorectal adenomas.
2023Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome associated with low anterior resection syndrome after rectal cancer surgery.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multiomics Analysis Revealed Colorectal Cancer Pathogenesis.
2024Journal of proteome research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of Gut Microbiota and Fecal Metabolites in Patients with Colorectal Cancer-Associated Iron Deficiency Anemia.
2024Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Conventional Therapy Combined With Quxie Capsule Modulating Gut Microbiome in Metastatic Colorectal Cancer Patients With the Third or Above Line Setting: Result From an Investigator-Initiated, Open-Label, Single-Arm, Phase II Study.
2024Integrative cancer therapies
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct microbes, metabolites, and the host genome define the multi-omics profiles in right-sided and left-sided colon cancer.
2024Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer.
2024Frontiers in pharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
3 papersA Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis.
2020Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation.
2021Biomedicines
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersThe Knowledge Gap in Gut Microbiome Characterization in Early-Onset Colorectal Cancer Patients: A Systematic Scoping Review.
2025Cancers
Relevant review or meta-analysis for the signal-disease area.