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Faecalibacterium prausnitzii

type 2 diabetes

Faecalibacterium prausnitzii looks like a credible signal in type 2 diabetes, though some caution is still warranted.

Faecalibacterium prausnitzii shows a strong literature footprint in type 2 diabetes, with substantial central evidence and broader supporting literature.

faecalibacterium_prausnitzii
Credibility score
100
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 100Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
  • strong central evidence base
  • dense review literature
Main caveats
  • directionality and confounding still require curated review

Internal review flags

2 flags
review_heavy

Review literature is very dense relative to primary central evidence.

sparse_primary_supporting_bucket

Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.

Primary central evidence

37 papers
Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters.
2013
The pharmacogenomics journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity.
2014
Beneficial microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula.
2015
The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota of Obese, Type 2 Diabetic Individuals is Enriched in Faecalibacterium prausnitzii, Akkermansia muciniphila and Peptostreptococcus anaerobius after Weight Loss.
2016
Endocrine, metabolic & immune disorders drug targets
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association of type II diabetes with gut microbiota composition.
2017
Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Role of Gut Microbiota on Cardio-Metabolic Parameters and Immunity in Coronary Artery Disease Patients with and without Type-2 Diabetes Mellitus.
2017
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus.
2019
Bioscience reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity.
2020
Nature metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus.
2021
International journal of medical sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India.
2021
Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Non-Alcoholic Fatty Liver Disease Severity in Type 2 Diabetes Patients.
2021
Journal of personalized medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Blood microbiota composition in Iranian pre-diabetic and type 2 diabetic patients.
2021
Human antibodies
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Subclinical Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus.
2021
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Systematically assessing microbiome-disease associations identifies drivers of inconsistency in metagenomic research.
2022
PLoS biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Application of machine learning tools: Potential and useful approach for the prediction of type 2 diabetes mellitus based on the gut microbiome profile.
2022
Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome Alterations Associated with Diabetes in Mexican Americans in South Texas.
2022
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of the Lipid Profile, Type 2 Diabetes and Medication on the Metabolic Syndrome-Associated Gut Microbiome.
2022
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Similar bacterial signatures in the gut microbiota of type 1 and type 2 diabetes patients and its association with G protein-coupled receptor 41 and 43 gene expression.
2022
Journal of diabetes and metabolic disorders
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Bacterial Community and Metagenome Function in Asians with Type 2 Diabetes, According to Enterotypes.
2022
Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[The characteristics of gut microbiota in type 2 diabetes mellitus patients with hypertriglyceridemia].
2022
Zhonghua yi xue za zhi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the Gut Microbiota in Pregnant Women with Pregestational Type 2 Diabetes Mellitus.
2023
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecalibacterium prausnitzii Improves Lipid Metabolism Disorder and Insulin Resistance in Type 2 Diabetic Mice.
2023
British journal of biomedical science
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of gut microbiota associated with metabolic syndrome and type-2 diabetes mellitus in Mexican pediatric subjects.
2023
BMC pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of Benaglutide on Gut Microbiota and Fecal Metabolites in Patients with Type 2 Diabetes Mellitus.
2023
Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
GLP-1 receptor agonists modulate blood glucose levels in T2DM by affecting Faecalibacterium prausnitzii abundance in the intestine.
2023
Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhanced trimethylamine metabolism and gut dysbiosis in type 2 diabetes mellitus with microalbumin.
2023
Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A study on the association between gut microbiota, inflammation, and type 2 diabetes.
2024
Applied microbiology and biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Blood Metabolites Related to Fiber Intake and Type 2 Diabetes.
2024
Circulation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of Gut Microbiota in Pyogenic Liver Abscess Patients with and without Type 2 Diabetes Mellitus.
2024
Infection and drug resistance
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome signatures associated with type 2 diabetes in obesity in Mongolia.
2024
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the Composition and Diversity of the Intestinal Microbiota Associated with Carbohydrate Consumption in Type 2 Diabetes Mellitus Patients.
2024
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal Microbiota Composition in Patients with Type 2 Diabetes and Effects of Oral Antidiabetics.
2025
Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population.
2025
Journal of diabetes investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated analysis of gut microbiota, fecal and serum metabolites in type 2 diabetes mellitus with peripheral neuropathy.
2025
Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Research on the characteristics of gut microbiota in overweight patients with early-onset type 2 diabetes mellitus.
2025
Journal of diabetes investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying gut microbiota Faecalibacterium as a potential biomarker for distinguishing visceral or subcutaneous obese population.
2025
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecalibacterium prausnitzii Indicates Healthspan and Lifespan in Nonhuman Primates.
2025
The journal of nutrition, health & aging
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Preclinical supporting evidence

2 papers
Faecalibacterium prausnitzii-derived microbial anti-inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression.
2020
Journal of diabetes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Strains of Faecalibacterium prausnitzii and its extracts reduce blood glucose levels, percent HbA1c, and improve glucose tolerance without causing hypoglycemic side effects in diabetic and prediabetic mice.
2023
BMJ open diabetes research & care
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

27 papers
Microbiota and diabetes: an evolving relationship.
2014
Gut
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiome in Obesity and Diabetes Mellitus.
2015
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Relevant review or meta-analysis for the signal-disease area.
Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery.
2018
European journal of endocrinology
Relevant review or meta-analysis for the signal-disease area.
Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review.
2019
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.
2019
Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Dietary Factors and Modulation of Bacteria Strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: A Systematic Review.
2019
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Role of gut microbiota in type 2 diabetes pathophysiology.
2020
EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review.
2022
Reproductive sciences (Thousand Oaks, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022
Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Dietary regulations for microbiota dysbiosis among post-menopausal women with type 2 diabetes.
2023
Critical reviews in food science and nutrition
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs.
2022
The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Composition in Prediabetes and Newly Diagnosed Type 2 Diabetes: A Systematic Review of Observational Studies.
2022
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Dried Fruits: Bioactives, Effects on Gut Microbiota, and Possible Health Benefits-An Update.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Prebiotics Progress Shifts in the Intestinal Microbiome That Benefits Patients with Type 2 Diabetes Mellitus.
2023
Biomolecules
Relevant review or meta-analysis for the signal-disease area.
Unravelling the Crosstalk between Estrogen Deficiency and Gut-biotaDysbiosis in the Development of Diabetes Mellitus.
2024
Current diabetes reviews
Relevant review or meta-analysis for the signal-disease area.
Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics.
2024
Probiotics and antimicrobial proteins
Relevant review or meta-analysis for the signal-disease area.
Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes.
2024
Nutrients
Relevant review or meta-analysis for the signal-disease area.
A systematic review on gut microbiota in type 2 diabetes mellitus.
2024
Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Dietary Manipulation on Gut Microbiome in Patients with Diabetes and Colorectal cancer.
2025
Current nutrition reports
Relevant review or meta-analysis for the signal-disease area.
In Search of Healthy Ageing: A Microbiome-Based Precision Nutrition Approach for Type 2 Diabetes Prevention.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus.
2025
Future microbiology
Relevant review or meta-analysis for the signal-disease area.
Exercise-induced modulation of gut microbiota in individuals with obesity and type 2 diabetes: a systematic review and meta-analysis.
2025
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiota-Metabolic Axis: Emerging Insights from Human and Experimental Studies on Type 2 Diabetes Mellitus-A Narrative Review.
2025
Medicina (Kaunas, Lithuania)
Relevant review or meta-analysis for the signal-disease area.
The Gut Nexus: Unraveling Microbiota-Mediated Links Between Type 2 Diabetes and Colorectal Cancer.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Intermittent Fasting and Probiotics for Gut Microbiota Modulation in Type 2 Diabetes Mellitus: A Narrative Review.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, sarcopenia, and type 2 diabetes: a triangular pathophysiological network.
2026
Journal of diabetes and metabolic disorders
Relevant review or meta-analysis for the signal-disease area.