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Faecalibacterium prausnitzii

obesity

Faecalibacterium prausnitzii looks like a credible signal in obesity, though some caution is still warranted.

Faecalibacterium prausnitzii shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.

faecalibacterium_prausnitzii
Credibility score
100
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 100Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
  • strong central evidence base
  • dense review literature
Main caveats
  • directionality and confounding still require curated review

Internal review flags

2 flags
review_heavy

Review literature is very dense relative to primary central evidence.

sparse_primary_supporting_bucket

Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.

Primary central evidence

30 papers
Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children.
2010
The British journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity.
2014
Beneficial microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation between diet and gut bacteria in a population of young adults.
2016
International journal of food sciences and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Markers in Obese Adolescent and Adult Patients: Age-Dependent Differential Patterns.
2018
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake.
2020
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of Gut Microbiota Composition in Hemodialysis Patients With Normal Weight Obesity.
2020
The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Newly Explored Faecalibacterium Diversity Is Connected to Age, Lifestyle, Geography, and Disease.
2020
Current biology : CB
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.
2021
Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota in people with obesity.
2021
PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Global research trends on the links between the gut microbiota and diabetes between 2001 and 2021: A bibliometrics and visualized study.
2022
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alternation of the gut microbiota in metabolically healthy obesity: An integrated multiomics analysis.
2022
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of gut dominant microbiota in obese patients with nonalcoholic fatty liver disease.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Williams-Beuren syndrome shapes the gut microbiota metaproteome.
2023
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.
2023
EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamical alterations of brain function and gut microbiome in weight loss.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Plant-based diets and the gut microbiome: findings from the Baltimore Longitudinal Study of Aging.
2024
The American journal of clinical nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer.
2024
Cell reports. Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiota and resting metabolic rate in overweight/obese women: a case-control study.
2024
Journal of diabetes and metabolic disorders
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adolescent gut microbiome imbalance and its association with immune response in inflammatory bowel diseases and obesity.
2024
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tailored impact of dietary fibers on gut microbiota: a multi-omics comparison on the lean and obese microbial communities.
2024
Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of daily avocado consumption on gut microbiota in adults with abdominal obesity: an ancillary study of HAT, a randomized controlled trial.
2025
Food & function
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts.
2025
The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-term arsenic exposure perturbs gut microbial diversity, composition and predicts metabolic dysregulation.
2025
Journal of hazardous materials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Shifts After a Weight Loss Program in Adults with Obesity: The WLM3P Study.
2025
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiota composition and cardiometabolic parameters in healthy adults.
2025
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The ecology of the microbiota in children with obesity is associated with the intake of carbohydrates and insulin resistance.
2025
Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying gut microbiota Faecalibacterium as a potential biomarker for distinguishing visceral or subcutaneous obese population.
2025
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral and fecal microbiota in Chinese adults with obesity reveal potential niche-specific microbiota associated with obesity.
2025
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes.
2025
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Children's gut microbiota predicts the efficacy of obesity treatment.
2026
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Preclinical supporting evidence

1 papers
Pharmaceutical efficacy of novel human-origin Faecalibacterium prausnitzii strains on high-fat-diet-induced obesity and associated metabolic disorders in mice.
2023
Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

33 papers
Impact of the gut microbiota on rodent models of human disease.
2014
World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiome in Obesity and Diabetes Mellitus.
2015
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Relevant review or meta-analysis for the signal-disease area.
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
2018
European journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery.
2018
European journal of endocrinology
Relevant review or meta-analysis for the signal-disease area.
Targeting obesity management through gut microbiota modulation by herbal products: A systematic review.
2019
Complementary therapies in medicine
Relevant review or meta-analysis for the signal-disease area.
Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review.
2019
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.
2019
Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Gut Dysfunction and Non-alcoholic Fatty Liver Disease.
2019
Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
Profile of the gut microbiota of adults with obesity: a systematic review.
2020
European journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives.
2020
Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020
Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review.
2022
Reproductive sciences (Thousand Oaks, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Parameters Potentially Useful in Clinical Perspective.
2021
Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders.
2021
Frontiers in pharmacology
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022
Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022
Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs.
2022
The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Fasting intervention and its clinical effects on the human host and microbiome.
2023
Journal of internal medicine
Relevant review or meta-analysis for the signal-disease area.
The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives.
2023
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Dried Fruits: Bioactives, Effects on Gut Microbiota, and Possible Health Benefits-An Update.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Contribution of the microbiome for better phenotyping of people living with obesity.
2023
Reviews in endocrine & metabolic disorders
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals gut microbiome and functional pathway alterations in response to resistant starch.
2023
Food & function
Relevant review or meta-analysis for the signal-disease area.
Anaerobes in specific infectious and noninfectious diseases: new developments.
2023
Anaerobe
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics.
2024
Probiotics and antimicrobial proteins
Relevant review or meta-analysis for the signal-disease area.
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review.
2024
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.
2025
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus.
2025
Future microbiology
Relevant review or meta-analysis for the signal-disease area.
Association between gut microbiota and pediatric obesity: A systematic review.
2025
Nutrition (Burbank, Los Angeles County, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Disrupting the Gut-Brain Axis: How Artificial Sweeteners Rewire Microbiota and Reward Pathways.
2025
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review.
2025
Endocrinologia, diabetes y nutricion
Relevant review or meta-analysis for the signal-disease area.