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Faecalibacterium prausnitzii

atopic dermatitis

Faecalibacterium prausnitzii is an interesting but still moderate-confidence signal in atopic dermatitis.

Faecalibacterium prausnitzii shows a strong literature footprint in atopic dermatitis, with substantial central evidence and broader supporting literature.

faecalibacterium_prausnitzii
Credibility score
43
Human translation
5/5
Reproducibility
4/5
Novelty
3/5
Actionability
3/5
Credibility 43Human translation 5/5Reproducibility 4/5Novelty 3/5Actionability 3/5
Why this scores the way it does
  • strong central evidence base
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

16 papers
Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis.
2016
The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants.
2016
Pediatric research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study.
2018
International archives of allergy and immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture.
2019
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood.
2020
Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial.
2021
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral administration of Faecalibacterium prausnitzii and Akkermansia muciniphila strains from humans improves atopic dermatitis symptoms in DNCB induced NC/Nga mice.
2022
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility.
2023
Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dupilumab therapy improves gut microbiome dysbiosis and tryptophan metabolism in Chinese patients with atopic dermatitis.
2024
International immunopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota and serum metabolism in patients with atopic dermatitis.
2024
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.
2024
Food science of animal resources
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study.
2025
The World Allergy Organization journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Causal relationship between Faecalibacterium abundance and risk of Faecalibacterium-related diseases: a two-sample bi-directional Mendelian randomisation study.
2025
Beneficial microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Maternal Faecalibacterium pathobionts and low-fiber diets synergize to impact offspring health: implications for atopic dermatitis.
2025
Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Next-Generation Probiotics in Allergy Therapy: Scientific Evidence and Clinical Applications.
2025
Anti-inflammatory & anti-allergy agents in medicinal chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Study on the characteristics and differences of intestinal microbiota in children with allergic diseases].
2026
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Preclinical supporting evidence

1 papers
Limosilactobacillus reuteri FN041 prevents atopic dermatitis in pup mice by remodeling the ileal microbiota and regulating gene expression in Peyer's patches after vertical transmission.
2022
Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

3 papers
Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases.
2022
Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological comorbidities.
2025
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
The Emerging Role of Gut Microbiota in Inflammatory Skin Diseases: A Systematic Review.
2026
Experimental dermatology
Relevant review or meta-analysis for the signal-disease area.