review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Faecalibacterium
obesity
Faecalibacterium looks like a credible signal in obesity, though some caution is still warranted.
Faecalibacterium shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
faecalibacterium
Credibility score
80
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 80Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
2 flagssparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
Primary central evidence
23 papersFaecalibacterium prausnitzii phylotypes in type two diabetic, obese, and lean control subjects.
2016Beneficial microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake.
2020Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in Compositions of Oral and Fecal Microbiota between Patients with Obesity and Controls.
2021Medicina (Kaunas, Lithuania)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between metabolic status and gut microbiome in obese populations.
2021Microbial genomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota in people with obesity.
2021PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Obese dogs exhibit different fecal microbiome and specific microbial networks compared with normal weight dogs.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of gut dominant microbiota in obese patients with nonalcoholic fatty liver disease.
2023Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in nonalcoholic fatty liver disease: a PREDIMED-Plus trial sub analysis.
2023Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.
2023EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamical alterations of brain function and gut microbiome in weight loss.
2023Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer.
2024Cell reports. Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Transplant of gut microbiota ameliorates metabolic and heart disorders in rats fed with a hypercaloric diet by modulating microbial metabolism and diversity.
2024Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tailored impact of dietary fibers on gut microbiota: a multi-omics comparison on the lean and obese microbial communities.
2024Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults-A Double-Blind Trial.
2025Molecular nutrition & food research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts.
2025The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-term arsenic exposure perturbs gut microbial diversity, composition and predicts metabolic dysregulation.
2025Journal of hazardous materials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Shifts After a Weight Loss Program in Adults with Obesity: The WLM3P Study.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiota composition and cardiometabolic parameters in healthy adults.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The ecology of the microbiota in children with obesity is associated with the intake of carbohydrates and insulin resistance.
2025Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying gut microbiota Faecalibacterium as a potential biomarker for distinguishing visceral or subcutaneous obese population.
2025Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral and fecal microbiota in Chinese adults with obesity reveal potential niche-specific microbiota associated with obesity.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Children's gut microbiota predicts the efficacy of obesity treatment.
2026Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Review supporting evidence
27 papersRole of the Gut Microbiome in Obesity and Diabetes Mellitus.
2015Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Relevant review or meta-analysis for the signal-disease area.
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
2018European journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Targeting obesity management through gut microbiota modulation by herbal products: A systematic review.
2019Complementary therapies in medicine
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.
2019Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Gut Dysfunction and Non-alcoholic Fatty Liver Disease.
2019Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
Profile of the gut microbiota of adults with obesity: a systematic review.
2020European journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives.
2020Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review.
2022Reproductive sciences (Thousand Oaks, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders.
2021Frontiers in pharmacology
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs.
2022The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Fasting intervention and its clinical effects on the human host and microbiome.
2023Journal of internal medicine
Relevant review or meta-analysis for the signal-disease area.
The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives.
2023International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Dried Fruits: Bioactives, Effects on Gut Microbiota, and Possible Health Benefits-An Update.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
Contribution of the microbiome for better phenotyping of people living with obesity.
2023Reviews in endocrine & metabolic disorders
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals gut microbiome and functional pathway alterations in response to resistant starch.
2023Food & function
Relevant review or meta-analysis for the signal-disease area.
Anaerobes in specific infectious and noninfectious diseases: new developments.
2023Anaerobe
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics.
2024Probiotics and antimicrobial proteins
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.
2025Gut microbes
Relevant review or meta-analysis for the signal-disease area.
The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus.
2025Future microbiology
Relevant review or meta-analysis for the signal-disease area.
Association between gut microbiota and pediatric obesity: A systematic review.
2025Nutrition (Burbank, Los Angeles County, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review.
2025Endocrinologia, diabetes y nutricion
Relevant review or meta-analysis for the signal-disease area.