review_heavy
Review literature is very dense relative to primary central evidence.
fulltoplow inflation risk
Faecalibacterium
inflammatory bowel disease
Faecalibacterium looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Faecalibacterium shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
faecalibacterium
Credibility score
67
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 67Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
19 papersA decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis.
2014Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial.
2020Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis.
2021Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota profile in patients with inflammatory bowel disease in Taiwan.
2021Journal of the Chinese Medical Association : JCMA
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Acupuncture improves the symptoms, intestinal microbiota, and inflammation of patients with mild to moderate Crohn's disease: A randomized controlled trial.
2022EClinicalMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Insight into gut dysbiosis of patients with inflammatory bowel disease and ischemic colitis.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inflammatory bowel disease biomarkers revealed by the human gut microbiome network.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota signatures in inflammatory bowel disease.
2024United European gastroenterology journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbial Species and Endotypes Associate with Remission in Ulcerative Colitis Patients Treated with Anti-TNF or Anti-integrin Therapy.
2024Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Study of Fecalibacteria prausntzii in Egyptian patients with inflammatory bowel disease.
2024Przeglad gastroenterologiczny
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecalibaterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors.
2024Oncoimmunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn's disease.
2025Cell metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecalibacterium Diversity in the Gut Microbiome of Crohn's Disease Patients.
2025United European gastroenterology journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecalibacterium Prausnitzii extracellular vesicles regulating macrophage differentiation via homologous recombination repair in colitis model.
2025Microbiological research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics.
2025Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
4 papersGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.
2023Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii Induces an Anti-inflammatory Response and a Metabolic Reprogramming in Human Monocytes.
2026Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
23 papersBifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Impact of Omega-3 Fatty Acids on the Gut Microbiota.
2017International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Intestinal Dysbiosis Secondary to Proton-Pump Inhibitor Use.
2018Digestion
Relevant review or meta-analysis for the signal-disease area.
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
2019Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences.
2019United European gastroenterology journal
Relevant review or meta-analysis for the signal-disease area.
Systematic review and meta-analysis of the role of Faecalibacterium prausnitzii alteration in inflammatory bowel disease.
2021Journal of gastroenterology and hepatology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review.
2021Frontiers in pediatrics
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Inflammatory Bowel Disease and COVID-19: How Microbiomics and Metabolomics Depict Two Sides of the Same Coin.
2022Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Alteration of the Gut Microbiome in Inflammatory Bowel Disease.
2023Digestion
Relevant review or meta-analysis for the signal-disease area.
Assessing the Relationship between the Gut Microbiota and Inflammatory Bowel Disease Therapeutics: A Systematic Review.
2023Pathogens (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Faecalibacterium: a bacterial genus with promising human health applications.
2023FEMS microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
Exploring the relationship between Faecalibacterium duncaniae and Escherichia coli in inflammatory bowel disease (IBD): Insights and implications.
2024Computational and structural biotechnology journal
Relevant review or meta-analysis for the signal-disease area.
Gut bacteriome in inflammatory bowel disease: An update on recent advances.
2024Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review.
2024Microbiological research
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go?
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Inflammatory Bowel Disease and Colorectal Cancer: An Eternal Fire in a Beautiful Garden.
2024South Asian journal of cancer
Relevant review or meta-analysis for the signal-disease area.
Comparative analysis of Parkinson's and inflammatory bowel disease gut microbiomes reveals shared butyrate-producing bacteria depletion.
2025NPJ Parkinson's disease
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD).
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease.
2025Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
Diet and Gut Microbiota in Inflammatory Bowel Disease: A Clinical and Nutritional Perspective.
2026Pharmaceuticals (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
The Role of Microbiota and Fecal Transplantation in Inflammatory Bowel Disease.
2026Pathogens (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.