sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Faecalibacterium
autism
Faecalibacterium appears to be a strong and relatively human-grounded signal in autism.
Faecalibacterium shows a strong literature footprint in autism, with substantial central evidence and broader supporting literature.
faecalibacterium
Credibility score
75
Human translation
5/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 75Human translation 5/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
26 papersFecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified.
2013PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A prebiotic intervention study in children with autism spectrum disorders (ASDs).
2018Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Features in Young Children With Autism Spectrum Disorders.
2018Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders.
2020Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clostridiales are predominant microbes that mediate psychiatric disorders.
2020Journal of psychiatric research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota changes in patients with autism spectrum disorders.
2020Journal of psychiatric research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders.
2020Frontiers in psychiatry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China: A case-control study.
2021Synthetic and systems biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases.
2023Journal of Alzheimer's disease : JAD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota as Potential Biomarkers for Autism Spectrum Disorder in Early Childhood.
2023Neuroscience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomics revealed a correlation of gut phageome with autism spectrum disorder.
2023Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Understanding the link between gut microbiota, dietary intake, and nutritional status in children with autism and typical development.
2023Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and serum amino acid metabolome alterations in autism spectrum disorder.
2024Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alteration of the gut microbiota profile in children with autism spectrum disorder in China.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder.
2024mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank.
2024Brain, behavior, & immunity - health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of Gut Bacterial and Fungal Microbiota in Children with Autism Spectrum Disorder and Their Non-Autistic Siblings.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correction of Batch Effect in Gut Microbiota Profiling of ASD Cohorts from Different Geographical Origins.
2024Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metataxonomic and Immunological Analysis of Feces from Children with or without Phelan-McDermid Syndrome.
2024Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Causal relationship between Faecalibacterium abundance and risk of Faecalibacterium-related diseases: a two-sample bi-directional Mendelian randomisation study.
2025Beneficial microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.
2025Autism research : official journal of the International Society for Autism Research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and urine metabolomics signature in autism spectrum disorder children from Southern China.
2025BMC pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in children and adolescents with autism, ADHD and anorexia nervosa, and its link to the levels of satiety hormones.
2025Neuroscience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota characteristics and therapeutic effects of fecal microbiota transplantation in children with autism spectrum disorder in central China: a combined cross-sectional and prospective study.
2025Frontiers in pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Observation of the Therapeutic Effect of Washed Microbiota Transplantation on Childhood Autism Spectrum Disorder.
2026Actas espanolas de psiquiatria
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral and Gut Microbiota in Individuals With Autism Spectrum Disorder: A Pilot Case-Control Study.
2026International journal of paediatric dentistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
1 papersThe gut commensal Faecalibacterium hominis attenuates indole-AhR signaling and restores ASD-like behaviors with BTBR mice.
2025Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
13 papersBifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD.
2019Medicina (Kaunas, Lithuania)
Relevant review or meta-analysis for the signal-disease area.
Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
2019Frontiers in psychiatry
Relevant review or meta-analysis for the signal-disease area.
Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
2020Nutrients
Relevant review or meta-analysis for the signal-disease area.
Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases.
2022Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Profiles in Children and Adolescents with Psychiatric Disorders.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
2023Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Genus-Level Analysis of Gut Microbiota in Children with Autism Spectrum Disorder: A Mini Review.
2023Children (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
A comparison between children and adolescents with autism spectrum disorders and healthy controls in biomedical factors, trace elements, and microbiota biomarkers: a meta-analysis.
2023Frontiers in psychiatry
Relevant review or meta-analysis for the signal-disease area.
Functional contribution of the intestinal microbiome in autism spectrum disorder, attention deficit hyperactivity disorder, and Rett syndrome: a systematic review of pediatric and adult studies.
2024Frontiers in neuroscience
Relevant review or meta-analysis for the signal-disease area.
Revealing the gut microbiome mystery: A meta-analysis revealing differences between individuals with autism spectrum disorder and neurotypical children.
2024Bioscience trends
Relevant review or meta-analysis for the signal-disease area.
Retrospective review: single- and multidonor washed microbiota transplantation have equivalent efficacy in the treatment of autism.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological comorbidities.
2025Gut microbes
Relevant review or meta-analysis for the signal-disease area.