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Eubacterium rectale

obesity

Eubacterium rectale appears to be a strong and relatively human-grounded signal in obesity.

Eubacterium rectale shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.

eubacterium_rectale
Credibility score
94
Human translation
4/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 94Human translation 4/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • meaningful supporting human literature
  • dense review literature
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

30 papers
Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces.
2007
Applied and environmental microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children.
2010
The British journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dominant and diet-responsive groups of bacteria within the human colonic microbiota.
2011
The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health.
2011
The American journal of clinical nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Women with and without metabolic disorder differ in their gut microbiota composition.
2012
Obesity (Silver Spring, Md.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbial community in metabolic syndrome patients is modified by diet.
2016
The Journal of nutritional biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Relative Abundance in Bacterial and Fungal Gut Microbes in Obese Children: A Case Control Study.
2017
Childhood obesity (Print)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans.
2019
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota markers associated with obesity and overweight in Italian adults.
2021
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Buzhong Yiqi Prescription on the Gut Microbiota of Patients with Obesity Manifesting Polycystic Ovarian Syndrome.
2021
Evidence-based complementary and alternative medicine : eCAM
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the Gut Microbiota in Individuals with Overweight or Obesity during a Real-World Weight Loss Dietary Program: A Focus on the Bacteroides 2 Enterotype.
2021
Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Association Between Fecal Short-Chain Fatty Acids, Gut Microbiota, and Visceral Fat in Monozygotic Twin Pairs.
2022
Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fiber Consumption Mediates Differences in Several Gut Microbes in a Subpopulation of Young Mexican Adults.
2022
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Low-Carbohydrate Diet and Exercise Training on Gut Microbiota.
2022
Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of gut microbiota and inflammatory markers in obese patients with type 2 diabetes mellitus: post hoc analysis of a synbiotic interventional study.
2022
Bioscience of microbiota, food and health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alternation of the gut microbiota in metabolically healthy obesity: An integrated multiomics analysis.
2022
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Signature of Obese Adults Across Different Classifications.
2022
Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of gut dominant microbiota in obese patients with nonalcoholic fatty liver disease.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes that reflect dietary intakes and fecal water content.
2023
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota, a potential cause of higher insulin sensitivity in children with Prader-Willi syndrome.
2024
Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.
2023
EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Plant-based diets and the gut microbiome: findings from the Baltimore Longitudinal Study of Aging.
2024
The American journal of clinical nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024
Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.
2024
International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-trajectories of BMI, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study.
2025
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
2025
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Influence of taste and smell perception on weight loss induced by sleeve gastrectomy and its association with gut microbiota.
2025
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Propolis Modulates the Gut Microbiota-Gut Hormone-Liver AMPK Axis to Ameliorate High-Fat Diet-Induced Metabolic Disorders in Rats.
2025
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Children's gut microbiota predicts the efficacy of obesity treatment.
2026
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

2 papers
Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study.
2021
The American journal of clinical nutrition
Human primary paper with plausible association relevance to the disease context.
The Nutritional Intervention Improves the Metabolic Profile of Overweight and Obese PCOS Along with the Differences in Gut Microbiota.
2023
Reproductive sciences (Thousand Oaks, Calif.)
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

12 papers
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.
2012
Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota of adults with different metabolic phenotypes.
2021
Nutrition (Burbank, Los Angeles County, Calif.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography.
2021
Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of the gut microbiome, plasma metabolome, peripheral cells, and inflammatory cytokines on obesity: a bidirectional two-sample Mendelian randomization study and mediation analysis.
2024
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization.
2024
Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.
2024
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study.
2024
Journal of clinical biochemistry and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eubacterium siraeum suppresses fat deposition via decreasing the tyrosine-mediated PI3K/AKT signaling pathway in high-fat diet-induced obesity.
2024
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome composition and metabolic activity in metabolic-associated fatty liver disease.
2025
Virulence
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Perinatal bisphenol A exposure impairs gut microbial colonization: Implications for offspring obesity and neurodevelopment.
2025
Ecotoxicology and environmental safety
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Platycodonis radix polysaccharides suppress progression of high-fat-induced obesity through modulation of intestinal microbiota and metabolites.
2025
Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Types and characteristics of shared microbiota within families of ethnic minorities in Inner Mongolia.
2026
Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

13 papers
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Innovation in microbiome-based strategies for promoting metabolic health.
2017
Current opinion in clinical nutrition and metabolic care
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota: Metabolism and perspective in obesity.
2018
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review.
2018
Childhood obesity (Print)
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020
Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
The Potential Roles of Very Low Calorie, Very Low Calorie Ketogenic Diets and Very Low Carbohydrate Diets on the Gut Microbiota Composition.
2021
Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.
2021
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome and health: mechanistic insights.
2022
Gut
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation.
2022
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity.
2024
BMC microbiology
Relevant review or meta-analysis for the signal-disease area.
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review.
2024
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025
World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.