sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Eubacterium rectale
inflammatory bowel disease
Eubacterium rectale looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Eubacterium rectale shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
eubacterium_rectale
Credibility score
80
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 80Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
26 papersMucosal and invading bacteria in patients with inflammatory bowel disease compared with controls.
2002Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.
2005Journal of clinical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum.
2011Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.
2010World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying genomic and metabolic features that can underlie early successional and opportunistic lifestyles of human gut symbionts.
2012Genome research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Changes of fecal flora and its correlation with inflammatory indicators in patients with inflammatory bowel disease].
2013Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota in Pediatric Inflammatory Bowel Disease and Its Relation to Inflammation.
2015The American journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Ileal and Colonic Mucosal Microbiota in Canine Chronic Enteropathies.
2016PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota differs between children with Inflammatory Bowel Disease and healthy siblings in taxonomic and functional composition: a metagenomic analysis.
2017American journal of physiology. Gastrointestinal and liver physiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response.
2019Cells
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease.
2020Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Eubacterium rectale contributes to colorectal cancer initiation via promoting colitis.
2021Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of 2'-Fucosyllactose on Gut Microbiota Composition in Adults with Chronic Gastrointestinal Conditions: Batch Culture Fermentation Model and Pilot Clinical Trial Findings.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clinical response and changes in the fecal microbiota and metabolite levels after fecal microbiota transplantation in patients with inflammatory bowel disease and recurrent Clostridioides difficile infection.
2021Fujita medical journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Risk factors and characteristics of gut microbiota and metabolites in inflammatory bowel diseases patients with urolithiasis].
2022Zhonghua yi xue za zhi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study.
2024Journal of neuroinflammation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Establishing a novel inflammatory bowel disease prediction model based on gene markers identified from single nucleotide variants of the intestinal microbiota.
2022iMeta
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Microbiome in Quiescent Crohn's Disease With Persistent Symptoms Show Disruptions in Microbial Sulfur and Tryptophan Pathways.
2024Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and blood biomarkers in IBD-Related arthritis: insights from mendelian randomization.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn's Disease: A Cross-Sectional Study.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predicting Risk of Post-Treatment Relapse in Patients with Inflammatory Bowel Disease Based on Intestinal Microbiota.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease.
1974Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
13 papersReduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease.
2004Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model.
2013The ISME journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Active matrix metalloproteinase-8 and periodontal bacteria-interlink between periodontitis and inflammatory bowel disease?
2018Journal of periodontology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Combined analysis of metagenomic data revealed consistent changes of gut microbiome structure and function in inflammatory bowel disease.
2021Journal of applied microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Two-Sample Mendelian Randomization Analysis Investigates Causal Associations Between Gut Microbial Genera and Inflammatory Bowel Disease, and Specificity Causal Associations in Ulcerative Colitis or Crohn's Disease.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Heat-Killed Bifidobacterium bifidum B1628 May Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, and the Anti-Inflammatory Effect Is Associated with Gut Microbiota Modulation.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Unravelling specific diet and gut microbial contributions to inflammatory bowel disease.
2023Research square
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hippuric acid alleviates dextran sulfate sodium-induced colitis via suppressing inflammatory activity and modulating gut microbiota.
2024Biochemical and biophysical research communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Immunomodulatory Effects of a Probiotic Mixture: Alleviating Colitis in a Mouse Model through Modulation of Cell Activation Markers and the Gut Microbiota.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus fermentum 016 Alleviates Mice Colitis by Modulating Oxidative Stress, Gut Microbiota, and Microbial Metabolism.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mucosal Colonized Engineered Nissle 1917 for Targeted Gut Delivery and Restored Microbiota Homeostasis in Inflammatory Bowel Disease.
2026Small (Weinheim an der Bergstrasse, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eubacterium limosum modulates gut microbiota and produces anti-inflammatory metabolites to alleviate DSS-induced colitis.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
12 papersModification of intestinal flora in the treatment of inflammatory bowel disease.
2003Current pharmaceutical design
Relevant review or meta-analysis for the signal-disease area.
The beneficial effects of microflora, especially obligate anaerobes, and their products on the colonic environment in inflammatory bowel disease.
2005Current pharmaceutical design
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome diversity in acute infective and chronic inflammatory gastrointestinal diseases in North India.
2016Journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Interactions between gut bacteria and bile in health and disease.
2017Molecular aspects of medicine
Relevant review or meta-analysis for the signal-disease area.
Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention.
2017Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Features of Gut Microbiome Associated With Responses to Fecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review.
2022Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
Gut bacteriome in inflammatory bowel disease: An update on recent advances.
2024Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Comparative analysis of Parkinson's and inflammatory bowel disease gut microbiomes reveals shared butyrate-producing bacteria depletion.
2025NPJ Parkinson's disease
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome remodeling induced by microplastic exposure in humans.
2026Gut microbes
Relevant review or meta-analysis for the signal-disease area.