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Eubacterium hallii

obesity

Eubacterium hallii looks like a credible signal in obesity, though some caution is still warranted.

Eubacterium hallii shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.

eubacterium_hallii
Credibility score
79
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 79Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • meaningful supporting human literature
  • dense review literature
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

24 papers
Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants.
2014
Applied and environmental microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice.
2016
NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation.
2020
International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lifestyle modifications result in alterations in the gut microbiota in obese children.
2021
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota markers associated with obesity and overweight in Italian adults.
2021
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Low-Carbohydrate Diet and Exercise Training on Gut Microbiota.
2022
Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Intestinal Microbiota and Short-Chain Fatty Acids in Association with Advanced Metrics of Glycemia and Adiposity Among Young Adults with Type 1 Diabetes and Overweight or Obesity.
2022
Current developments in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alternation of the gut microbiota in metabolically healthy obesity: An integrated multiomics analysis.
2022
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Signature of Obese Adults Across Different Classifications.
2022
Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of gut dominant microbiota in obese patients with nonalcoholic fatty liver disease.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of summer acupoint application treatment (SAAT) on gut microbiota in healthy Asian adults: A randomized controlled trial.
2023
Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Serum Metabolites in Individuals with Class III Obesity Without Type 2 Diabetes Mellitus: Pilot Analysis.
2023
Metabolic syndrome and related disorders
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.
2023
EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Plant-based diets and the gut microbiome: findings from the Baltimore Longitudinal Study of Aging.
2024
The American journal of clinical nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024
Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.
2024
International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the gut microbiota community are associated with childhood obesity and precocious puberty.
2024
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal microbiota composition and impulsivity in a cohort of older adults with metabolic syndrome.
2024
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-trajectories of BMI, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study.
2025
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
2025
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Influence of taste and smell perception on weight loss induced by sleeve gastrectomy and its association with gut microbiota.
2025
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Propolis Modulates the Gut Microbiota-Gut Hormone-Liver AMPK Axis to Ameliorate High-Fat Diet-Induced Metabolic Disorders in Rats.
2025
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Children's gut microbiota predicts the efficacy of obesity treatment.
2026
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

2 papers
Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study.
2021
The American journal of clinical nutrition
Human primary paper with plausible association relevance to the disease context.
Impact of gut microbiota on metabolic syndrome and its comprising traits: a two-sample mendelian randomization study.
2024
Diabetology & metabolic syndrome
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

14 papers
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.
2012
Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial.
2019
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A multiphase dietetic protocol incorporating an improved ketogenic diet enhances weight loss and alters the gut microbiome of obese people.
2022
International journal of food sciences and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography.
2021
Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Causal relationship between gut microbiota with subcutaneous and visceral adipose tissue: a bidirectional two-sample Mendelian Randomization study.
2023
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association between gut microbiota at 3.5 years of age and body mass index at 5 years: results from two French nationwide birth cohorts.
2024
International journal of obesity (2005)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of the gut microbiome, plasma metabolome, peripheral cells, and inflammatory cytokines on obesity: a bidirectional two-sample Mendelian randomization study and mediation analysis.
2024
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.
2024
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study.
2024
Journal of clinical biochemistry and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eubacterium siraeum suppresses fat deposition via decreasing the tyrosine-mediated PI3K/AKT signaling pathway in high-fat diet-induced obesity.
2024
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome composition and metabolic activity in metabolic-associated fatty liver disease.
2025
Virulence
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Perinatal bisphenol A exposure impairs gut microbial colonization: Implications for offspring obesity and neurodevelopment.
2025
Ecotoxicology and environmental safety
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Platycodonis radix polysaccharides suppress progression of high-fat-induced obesity through modulation of intestinal microbiota and metabolites.
2025
Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dynamic impact of intermittent fasting and refeeding on metabolic health and microbiome-metabolome signatures in cynomolgus monkeys.
2026
Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

13 papers
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Innovation in microbiome-based strategies for promoting metabolic health.
2017
Current opinion in clinical nutrition and metabolic care
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota: Metabolism and perspective in obesity.
2018
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review.
2018
Childhood obesity (Print)
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020
Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.
2021
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome and health: mechanistic insights.
2022
Gut
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation.
2022
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity.
2024
BMC microbiology
Relevant review or meta-analysis for the signal-disease area.
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review.
2024
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Interventions: From Dysbiosis to Next-Generation Probiotics (NGPs) for Disease Management.
2025
Probiotics and antimicrobial proteins
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025
World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.