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Escherichia coli

atopic dermatitis

Escherichia coli looks like a credible signal in atopic dermatitis, though some caution is still warranted.

Escherichia coli shows a strong literature footprint in atopic dermatitis, with substantial central evidence and broader supporting literature.

escherichia_coli
Credibility score
78
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 78Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • meaningful supporting human literature
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

24 papers
Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.
2002
The Journal of investigative dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of recombinant cat albumin.
2003
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal microbiota in allergic and nonallergic 1-year-old very low birth weight infants after neonatal glutamine supplementation.
2010
Acta paediatrica (Oslo, Norway : 1992)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Staphylococcus aureus fibronectin-binding protein specifically binds IgE from patients with atopic dermatitis and requires antigen presentation for cellular immune responses.
2011
The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Cost-effectiveness analysis, prevention of atopic dermatitis by oral application of bacterial lysate in newborns/small children.
2013
The European journal of health economics : HEPAC : health economics in prevention and care
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Emergence and maintenance of multidrug-resistant Escherichia coli of canine origin harbouring a blaCMY-2-IncI1/ST65 plasmid and topoisomerase mutations.
2014
The Journal of antimicrobial chemotherapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6.
2015
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
In vitro antimicrobial effects of a novel Pentaherbs concoction for atopic dermatitis.
2018
The Journal of dermatological treatment
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type.
2018
The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study.
2018
International archives of allergy and immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Activation profile of THP-1 derived dendritic cells stimulated by allergen Mal f 1 beyond its IgE-binding ability.
2018
International immunopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Orally applied bacterial lysate in infants at risk for atopy does not prevent atopic dermatitis, allergic rhinitis, asthma or allergic sensitization at school age: Follow-up of a randomized trial.
2020
Allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diagnostic Models for Atopic Dermatitis Based on Serum Microbial Extracellular Vesicle Metagenomic Analysis: A Pilot Study.
2020
Allergy, asthma & immunology research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema.
2020
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota development during infancy: Impact of introducing allergenic foods.
2021
The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study.
2022
Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis.
2024
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal bacterial microbiota diversity characterized for dogs with atopic dermatitis: its alteration and clinical recovery after meat-exclusion diet.
2025
American journal of veterinary research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An insight into the gut microbiota of healthy and allergic West Highland Whiter Terrier dogs.
2025
PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population.
2025
The World Allergy Organization journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evaluating the Adjuvant Therapeutic Effects of Probiotic Strains Lactococcus cremoris and Lacticaseibacillus paracasei on Canine Atopic Dermatitis and Their Impact on the Gut and Skin Microbiome.
2025
Animals : an open access journal from MDPI
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between the composition of the early-life intestinal microbiome and eczema in the first year of life.
2023
Frontiers in microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Study on the characteristics and differences of intestinal microbiota in children with allergic diseases].
2026
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.
1998
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

3 papers
Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients.
2011
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Human primary paper with plausible association relevance to the disease context.
Study of The specificity of gut microbiota in adult patients with delayed-onset of atopic dermatitis.
2022
Allergologia et immunopathologia
Human primary paper with plausible association relevance to the disease context.
A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs.
2023
Microbiome
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

22 papers
Immunologic characterization of natural and recombinant Mal f 1 yeast allergen.
1999
The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study.
2007
Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus rhamnosus GG and Lactobacillus casei suppress Escherichia coli-induced chemokine expression in intestinal epithelial cells.
2009
International archives of allergy and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption.
2009
The Journal of investigative dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood.
2013
The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteria and endotoxin induce release of basophil histamine in patients with atopic dermatitis. In vitro experiments with S. aureus, teichoic acid, E. coli and E. coli LPS.
1987
Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.
2015
The Journal of investigative dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin.
2015
The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy.
2015
Allergology international : official journal of the Japanese Society of Allergology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Chemical characterization and immunomodulatory properties of polysaccharides isolated from probiotic Lactobacillus casei LOCK 0919.
2016
Glycobiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
House dust mites as potential carriers for IgE sensitization to bacterial antigens.
2018
Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ear canal microbiota - a comparison between healthy dogs and atopic dogs without clinical signs of otitis externa.
2018
Veterinary dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects.
2019
BMC dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bee Venom Alleviates Atopic Dermatitis Symptoms through the Upregulation of Decay-Accelerating Factor (DAF/CD55).
2019
Toxins
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33.
2021
The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diaper area skin microflora of normal children and children with atopic dermatitis.
1987
Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Recombinant PNPLA1 catalyzes the synthesis of acylceramides and acyl acids with selective incorporation of linoleic acid.
2023
Journal of lipid research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis.
2024
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
RETRACTED: Effect of Bifidobacterium bifidum Supplementation in Newborns Born from Cesarean Section on Atopy, Respiratory Tract Infections, and Dyspeptic Syndromes: A Multicenter, Randomized, and Controlled Clinical Trial.
2024
Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota profile and atopic dermatitis in the first year of life.
2024
Journal of medicine and life
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeting Barrier Reinforcement and MAPK Inhibition: Recombinant Mucin-Type Collagen Tandems Ameliorate Inflammation in TNF-α/IFN-γ-Induced Atopic Dermatitis-like HaCaT Keratinocytes.
2026
ACS synthetic biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Subpopulations of lymphocytes and lymphocyte transformation tests in atopic dermatitis: evaluation of a systemic treatment with a new chromone compound and comparison with a normal group.
1981
The Journal of investigative dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

5 papers
Recombinant interferon gamma for treatment of chronic granulomatous disease and other disorders.
1992
Clinical pharmacy
Relevant review or meta-analysis for the signal-disease area.
A new silver-loaded cellulosic fiber with antifungal and antibacterial properties.
2006
Current problems in dermatology
Relevant review or meta-analysis for the signal-disease area.
Bacterial lysates in food allergy prevention.
2013
Current opinion in allergy and clinical immunology
Relevant review or meta-analysis for the signal-disease area.
Oral application of bacterial lysate in infancy diminishes the prevalence of atopic dermatitis in children at risk for atopy.
2014
Beneficial microbes
Relevant review or meta-analysis for the signal-disease area.
Microbiology of infected atopic dermatitis.
1996
International journal of dermatology
Relevant review or meta-analysis for the signal-disease area.