Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives.
2011Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Dialister
crohn's disease
Dialister is an interesting but still moderate-confidence signal in crohn's disease.
Dialister shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
dialister
Credibility score
47
Human translation
5/5
Reproducibility
4/5
Novelty
3/5
Actionability
3/5
Credibility 47Human translation 5/5Reproducibility 4/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
Main caveats
- retrieval noise or disease-specificity issues may remain
Primary central evidence
19 papersCampylobacter concisus and exotoxin 9 levels in paediatric patients with Crohn's disease and their association with the intestinal microbiota.
2014Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Brief Report: Dialister as a Microbial Marker of Disease Activity in Spondyloarthritis.
2017Arthritis & rheumatology (Hoboken, N.J.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota in Health, Diverticular Disease, Irritable Bowel Syndrome, and Inflammatory Bowel Diseases: Time for Microbial Marker of Gastrointestinal Disorders.
2018Digestive diseases (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.
2018Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?
2018Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in the intestinal microbiome of healthy children and patients with newly diagnosed Crohn's disease.
2019Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multiomic features associated with mucosal healing and inflammation in paediatric Crohn's disease.
2020Alimentary pharmacology & therapeutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease.
2020Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adsorptive granulomonocytapheresis alters the gut bacterial microbiota in patients with active ulcerative colitis.
2021Journal of clinical apheresis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Study of microbiome changes in patients with ulcerative colitis in the Central European part of Russia.
2021Heliyon
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Establishment and evaluation of a specific antibiotic-induced inflammatory bowel disease model in rats.
2022PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammatory bowel disease and irritable bowel syndrome patients.
2022Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploring the Predictive Value of Gut Microbiome Signatures for Therapy Intensification in Patients With Inflammatory Bowel Disease: A 10-Year Follow-up Study.
2024Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status.
2024Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in Gut Phageome and Bacteriome Following Fecal Microbiota Transfer in Patients with Intestinal Graft-Versus-Host Disease and Crohn's Disease.
2025Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial and fungal biomarkers in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD): trans-kingdom interactions, Blastocystis carriage, and enterotype-succinotype stratification.
2026Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
1 papersPrebiotics effects in vitro of polysaccharides from tea flowers on gut microbiota of healthy persons and patients with inflammatory bowel disease.
2020International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersDysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go?
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.