preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Desulfovibrio
ulcerative colitis
Desulfovibrio has meaningful literature visibility in ulcerative colitis, but the current evidence mix suggests a substantial risk of overclaiming.
Desulfovibrio shows a moderate evidence base in ulcerative colitis, with multiple central papers and additional supporting literature.
desulfovibrio
Credibility score
49
Human translation
1/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 49Human translation 1/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
12 papersThe contribution of sulphate reducing bacteria and 5-aminosalicylic acid to faecal sulphide in patients with ulcerative colitis.
2000Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification and quantitation of mucosal and faecal desulfovibrios using real time polymerase chain reaction.
2004Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease.
2012FEMS immunology and medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Longitudinal analyses of gut mucosal microbiotas in ulcerative colitis in relation to patient age and disease severity and duration.
2013Journal of clinical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sulphate-reducing bacteria from ulcerative colitis patients induce apoptosis of gastrointestinal epithelial cells.
2017Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Toxicity of hydrogen sulfide toward sulfate-reducing bacteria Desulfovibrio piger Vib-7.
2019Archives of microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of pH Dose-dependent Growth of Sulfate-reducing Bacteria.
2019Open medicine (Warsaw, Poland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans.
2019Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Capsular Polysaccharide From Bacteroides fragilis Protects Against Ulcerative Colitis in an Undegraded Form.
2020Frontiers in pharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Corrosion in Orthodontics.
2022The journal of contemporary dental practice
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of prebiotic candidates in ulcerative colitis using an in vitro fermentation model.
2024Journal of applied microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lianweng formula alleviates colonic inflammation through gut microbiota-mediated inactivation of the PTGS2/AKR1C3/ALOX5 pathway and subsequent suppression of arachidonic acid metabolism.
2026Journal of ethnopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
38 papersSusceptibility of Desulfovibrio desulfuricans intestinal strains to sulfasalazine and its biotransformation products.
2004Medical science monitor : international medical journal of experimental and clinical research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
First isolation of Desulfovibrio from the human vaginal flora.
2010Anaerobe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Desulfovibrio bacterial species are increased in ulcerative colitis.
2010Diseases of the colon and rectum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis.
2010Annals of surgery
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Desulfovibrio desulfuricans bacteremia in an immunocompromised host with a liver graft and ulcerative colitis.
2012Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis.
2014Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Immunological alteration and changes of gut microbiota after dextran sulfate sodium (DSS) administration in mice.
2015Clinical and experimental medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Preliminary Study Examining the Binding Capacity of Akkermansia muciniphila and Desulfovibrio spp., to Colonic Mucin in Health and Ulcerative Colitis.
2015PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bismuth(III) deferiprone effectively inhibits growth of Desulfovibrio desulfuricans ATCC 27774.
2016Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota drives the attenuation of dextran sulphate sodium-induced colitis by Huangqin decoction.
2017Oncotarget
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.
2018Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon.
2018Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Metabolic Activity of Sulfate-Reducing Bacteria from Rodents with Colitis.
2018Open medicine (Warsaw, Poland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bismuth(III) interactions with Desulfovibrio desulfuricans: inhibition of cell energetics and nanocrystal formation of Bi2S3 and Bi0.
2019Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-inflammatory properties and gut microbiota modulation of an alkali-soluble polysaccharide from purple sweet potato in DSS-induced colitis mice.
2020International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kuijieyuan Decoction Improved Intestinal Barrier Injury of Ulcerative Colitis by Affecting TLR4-Dependent PI3K/AKT/NF-κB Oxidative and Inflammatory Signaling and Gut Microbiota.
2020Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Analysis of Physiological Parameters of Desulfovibrio Strains from Individuals with Colitis.
2018Open life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-Inflammatory Effects of Mytilus coruscus Polysaccharide on RAW264.7 Cells and DSS-Induced Colitis in Mice.
2021Marine drugs
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of ShenLing BaiZhu San Supplementation on Gut Microbiota and Oxidative Stress in Rats with Ulcerative Colitis.
2021Evidence-based complementary and alternative medicine : eCAM
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cereal Vinegar Sediment Alleviates Spontaneous Ulcerative Colitis in Il-10 Deficient Mice.
2021Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Zingiber officinale and Panax ginseng ameliorate ulcerative colitis in mice via modulating gut microbiota and its metabolites.
2022Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism.
2022Cellular and molecular life sciences : CMLS
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Jatrorrhizine alleviates ulcerative colitis via regulating gut microbiota and NOS2 expression.
2022Gut pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gas-Mediated Intestinal Microbiome Regulation Prompts the Methanol Extract of Schizonepetae Spica to Relieve Colitis.
2023Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.
2023Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cooperative interactions between Veillonella ratti and Lactobacillus acidophilus ameliorate DSS-induced ulcerative colitis in mice.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ginsenoside Rg1 Alleviates Ulcerative Colitis in Obese Mice by Regulating the Gut Microbiota-Lipid Metabolism-Th1/Th2/Th17 Cells Axis.
2023Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-κB/MAPK pathway.
2024International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-inflammatory probiotics HF05 and HF06 synergistically alleviate ulcerative colitis and secondary liver injury.
2024Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structural characteristics of a polysaccharide from Armillariella tabescens and its protective effect on colitis mice via regulating gut microbiota and intestinal barrier function.
2024International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii enhances intestinal IgA response by host-microbe derived inecalcitol in colitis.
2025BMC medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human gut strains of Desulfovibrio piger exhibit spontaneous induction of multiple prophages.
2025Applied and environmental microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enzymatically Hydrolyzed Wheat Bran-Derived Zinc Phytate Ameliorates Ulcerative Colitis via Synergistic Regulation of the Gut Microbiota-Intestinal Barrier Axis.
2025Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tanshinones from Salvia miltiorrhiza alleviate ulcerative colitis via reprogramming the gut microbiota-metabolite axis.
2026Acta biochimica et biophysica Sinica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Taraxacum alleviates ulcerative colitis, accompanied by the modulation of gut microbiota and restoration of intestinal barrier integrity.
2026Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Isolation and evaluation of susceptibility to sulphasalazine of Desulfovibrio desulfuricans strains from the human digestive tract.
1997Acta microbiologica Polonica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersHydrogen Sulfide in Physiology and Diseases of the Digestive Tract.
2015Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Possible synergy effect of hydrogen sulfide and acetate produced by sulfate-reducing bacteria on inflammatory bowel disease development.
2021Journal of advanced research
Relevant review or meta-analysis for the signal-disease area.
Bloodstream co-infection with Turicibacter sanguinis and Desulfovibrio desulfuricans in a patient with a flare of ulcerative colitis - A case report and review of the literature.
2024IDCases
Relevant review or meta-analysis for the signal-disease area.
Gingerols: Preparation, encapsulation, and bioactivities focusing gut microbiome modulation and attenuation of disease symptoms.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Relevant review or meta-analysis for the signal-disease area.