preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Desulfovibrio
obesity
Desulfovibrio has meaningful literature visibility in obesity, but the current evidence mix suggests a substantial risk of overclaiming.
Desulfovibrio shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
desulfovibrio
Credibility score
54
Human translation
2/5
Reproducibility
4/5
Novelty
3/5
Actionability
3/5
Credibility 54Human translation 2/5Reproducibility 4/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
15 papersDistinct Gut Microbiota and Serum Metabolites in Response to Weight Loss Induced by Either Dairy or Exercise in a Rodent Model of Obesity.
2019Journal of proteome research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health.
2020Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Molokhia leaf extract prevents gut inflammation and obesity.
2020Journal of ethnopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial.
2020Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight/Obesity Within the Frame of the PREDIMED-Plus Study.
2022Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An Investigation into the Correlation of Intestinal Flora with Obesity and Gestational Diabetes Mellitus.
2022Computational and mathematical methods in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis.
2022Lipids in health and disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in nonalcoholic fatty liver disease: a PREDIMED-Plus trial sub analysis.
2023Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The role of gut microbiota in the occurrence and progression of non-alcoholic fatty liver disease.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes.
2024Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome signatures associated with type 2 diabetes in obesity in Mongolia.
2024Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Hesperidin and Fecal Microbiota Transplantation Modulate the Composition of the Gut Microbiota and Reduce Obesity in High Fat Diet Mice.
2024Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Parent-child microbiota relationships involved in childhood obesity: A CORALS ancillary study.
2025Nutrition (Burbank, Los Angeles County, Calif.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Higher Abundance of Genus Desulfovibrio May Underlie Resistance to Antipsychotic-Induced Weight Gain in Schizophrenia.
2026Schizophrenia bulletin
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
31 papersAltered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure.
2016Cell metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders.
2017EBioMedicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice.
2017Diabetes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Difference in the Gut Microbiome between Ovariectomy-Induced Obesity and Diet-Induced Obesity.
2017Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Identifying psychiatric disorder-associated gut microbiota using microbiota-related gene set enrichment analysis.
2020Briefings in bioinformatics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
T cell-mediated regulation of the microbiota protects against obesity.
2019Science (New York, N.Y.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of theabrownin on serum metabolites and gut microbiome in rats with a high-sugar diet.
2019Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet.
2020International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Endurance exercise ameliorates Western diet-induced atherosclerosis through modulation of microbiota and its metabolites.
2022Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coreopsis tinctoria and Its Flavonoids Ameliorate Hyperglycemia in Obese Mice Induced by High-Fat Diet.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Quinoa Reduces High-Fat Diet-Induced Obesity in Mice via Potential Microbiota-Gut-Brain-Liver Interaction Mechanisms.
2022Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet Is a Stronger Covariate than Exercise in Determining Gut Microbial Richness and Diversity.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of High-Fat Diet During Childhood on Precocious Puberty and Gut Microbiota in Mice.
2022Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of the gut microbiota and lipidomic profiles by black chokeberry (Aronia melanocarpa L.) polyphenols via the glycerophospholipid metabolism signaling pathway.
2022Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Chronic lead exposure exacerbates hepatic glucolipid metabolism disorder and gut microbiota dysbiosis in high-fat-diet mice.
2022Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.
2022Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Metagenomic Insights into the Anti-Obesity Effect of a Polysaccharide from Saccharina japonica.
2023Foods (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intestinal microbiome characterization of adult Brazilian men with psoriasis compared to omnivore and vegetarian controls.
2023Anais brasileiros de dermatologia
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of Fat Deposition-Gut Interactions in Obese Mice by Administrating with Nobiletin.
2023Genes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Probiotic OMNi-BiOTiC® 10 AAD Reduces Cyclophosphamide-Induced Inflammation and Adipose Tissue Wasting in Mice.
2023Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Unraveling the mystery: a Mendelian randomized exploration of gut microbiota and different types of obesity.
2024Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Decreased circulating IPA levels identify subjects with metabolic comorbidities: A multi-omics study.
2024Pharmacological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gualou-Xiebai-Banxia-Tang regulates liver-gut axis to ameliorate Metabolic Syndrome in HFD-fed mice.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Renoprotective effects of empagliflozin in high-fat diet-induced obesity-related glomerulopathy by regulation of gut-kidney axis.
2024American journal of physiology. Cell physiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Capsaicin Reduces Obesity by Reducing Chronic Low-Grade Inflammation.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet-Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis.
2024Environmental health perspectives
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Endurance Exercise Training on Gut Microbiota and ER Stress.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gallic acid prevents obesity in mice on a high-fat diet via the gut microbiota-adipose tissue axis.
2025Current research in food science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Lactation Lactoferrin Deficiency on Intestinal Microbiota in Different Mice Models.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial Signatures of Obesity-Aggravated Psoriasis: Insights from an Imiquimod-Based Mouse Model.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
6 papersGallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
The Modulation of Gut Microbiota Composition in the Pathophysiology of Gestational Diabetes Mellitus: A Systematic Review.
2021Biology
Relevant review or meta-analysis for the signal-disease area.
Relationship between changes in microbiota induced by resveratrol and its anti-diabetic effect on type 2 diabetes.
2022Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Beneficial effects of seaweed-derived components on metabolic syndrome via gut microbiota modulation.
2023Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Gingerols: Preparation, encapsulation, and bioactivities focusing gut microbiome modulation and attenuation of disease symptoms.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Relevant review or meta-analysis for the signal-disease area.
Interaction between dietary omega-3 polyunsaturated fatty acids, obesity and gut microbiota in preclinical models: A systematic review of randomized controlled trials.
2025Diabetes, obesity & metabolism
Relevant review or meta-analysis for the signal-disease area.