preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Desulfovibrio
inflammatory bowel disease
Desulfovibrio has meaningful literature visibility in inflammatory bowel disease, but the current evidence mix suggests a substantial risk of overclaiming.
Desulfovibrio shows a moderate evidence base in inflammatory bowel disease, with multiple central papers and additional supporting literature.
desulfovibrio
Credibility score
44
Human translation
2/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 44Human translation 2/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
12 papersHuman inflammatory bowel disease does not associate with Lawsonia intracellularis infection.
2006BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.
2010World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
On the relationship between sialomucin and sulfomucin expression and hydrogenotrophic microbes in the human colonic mucosa.
2011PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease.
2012FEMS immunology and medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Toxicity of hydrogen sulfide toward sulfate-reducing bacteria Desulfovibrio piger Vib-7.
2019Archives of microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of pH Dose-dependent Growth of Sulfate-reducing Bacteria.
2019Open medicine (Warsaw, Poland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Notch Signaling Pathway Is Activated by Sulfate Reducing Bacteria.
2021Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Norepinephrine induces growth of Desulfovibrio vulgaris in an iron dependent manner.
2022Anaerobe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of prebiotic candidates in ulcerative colitis using an in vitro fermentation model.
2024Journal of applied microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predicting Risk of Post-Treatment Relapse in Patients with Inflammatory Bowel Disease Based on Intestinal Microbiota.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Milk Kefir Beverage Improves Histomorphometry, Reduces Inflammatory Infiltrates and Desulfovibrio and Increases Lactobacillus in IL-10-/- Mice.
2026Journal of food science
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersSulfate-Reducing Bacteria Induce Pro-Inflammatory TNF-α and iNOS via PI3K/Akt Pathway in a TLR 2-Dependent Manner.
2024Microorganisms
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
23 papersMolecular characterisation of the gut microflora of healthy and inflammatory bowel disease cats using fluorescence in situ hybridisation with special reference to Desulfovibrio spp.
2007Journal of animal physiology and animal nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases.
2002FEMS microbiology ecology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Glycomacropeptide is a prebiotic that reduces Desulfovibrio bacteria, increases cecal short-chain fatty acids, and is anti-inflammatory in mice.
2015American journal of physiology. Gastrointestinal and liver physiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pretreatment with probiotic Bifico ameliorates colitis-associated cancer in mice: Transcriptome and gut flora profiling.
2018Cancer science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.
2018Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Absorption of Codonopsis pilosula Saponins by Coexisting Polysaccharides Alleviates Gut Microbial Dysbiosis with Dextran Sulfate Sodium-Induced Colitis in Model Mice.
2018BioMed research international
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis.
2018Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary Taxifolin Protects Against Dextran Sulfate Sodium-Induced Colitis via NF-κB Signaling, Enhancing Intestinal Barrier and Modulating Gut Microbiota.
2020Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Analysis of Physiological Parameters of Desulfovibrio Strains from Individuals with Colitis.
2018Open life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cereal Vinegar Sediment Alleviates Spontaneous Ulcerative Colitis in Il-10 Deficient Mice.
2021Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prenatal Maternal Stress Exacerbates Experimental Colitis of Offspring in Adulthood.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Protective effect and mechanism of Bifidobacterium bifidum TMC3115 on long-term colitis in mice which exposed to antibiotic in early life].
2022Wei sheng yan jiu = Journal of hygiene research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
TNF ΔARE Pigs: A Translational Crohn's Disease Model.
2023Journal of Crohn's & colitis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis.
2023Frontiers of medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The maca protein ameliorates DSS-induced colitis in mice by modulating the gut microbiota and production of SCFAs.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Sichuan pepper (huājiāo) powder on disease activity and caecal microbiota of dextran sodium sulphate-induced inflammatory bowel disease mouse model.
2024Molecular biology reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.
2025Behavioral and brain functions : BBF
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Lactation Lactoferrin Deficiency on Intestinal Microbiota in Different Mice Models.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structural characterization of polysaccharides from 'Nanguo' pear and its protective effect against inflammatory bowel disease in mice via modulating gut microbiota.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human gut strains of Desulfovibrio piger exhibit spontaneous induction of multiple prophages.
2025Applied and environmental microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tanshinones from Salvia miltiorrhiza alleviate ulcerative colitis via reprogramming the gut microbiota-metabolite axis.
2026Acta biochimica et biophysica Sinica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersIntestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases?
2013Best practice & research. Clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria.
2020Cells
Relevant review or meta-analysis for the signal-disease area.
Possible synergy effect of hydrogen sulfide and acetate produced by sulfate-reducing bacteria on inflammatory bowel disease development.
2021Journal of advanced research
Relevant review or meta-analysis for the signal-disease area.
Desulfovibrio in the Gut: The Enemy within?
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.