preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Desulfovibrio
crohn's disease
Desulfovibrio has meaningful literature visibility in crohn's disease, but the current evidence mix suggests a substantial risk of overclaiming.
Desulfovibrio shows a moderate evidence base in crohn's disease, with multiple central papers and additional supporting literature.
desulfovibrio
Credibility score
46
Human translation
1/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 46Human translation 1/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
11 papersHuman inflammatory bowel disease does not associate with Lawsonia intracellularis infection.
2006BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.
2010World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
On the relationship between sialomucin and sulfomucin expression and hydrogenotrophic microbes in the human colonic mucosa.
2011PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease.
2012FEMS immunology and medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics.
2017Digestive diseases and sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Toxicity of hydrogen sulfide toward sulfate-reducing bacteria Desulfovibrio piger Vib-7.
2019Archives of microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evaluation of Physiological Parameters of Intestinal Sulfate-Reducing Bacteria Isolated from Patients Suffering from IBD and Healthy People.
2020Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Norepinephrine induces growth of Desulfovibrio vulgaris in an iron dependent manner.
2022Anaerobe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Corrosion in Orthodontics.
2022The journal of contemporary dental practice
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predicting Risk of Post-Treatment Relapse in Patients with Inflammatory Bowel Disease Based on Intestinal Microbiota.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersThe Capacity to Produce Hydrogen Sulfide (H2S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome.
2021Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.
Sulfate-Reducing Bacteria Induce Pro-Inflammatory TNF-α and iNOS via PI3K/Akt Pathway in a TLR 2-Dependent Manner.
2024Microorganisms
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
28 papersSusceptibility of Desulfovibrio desulfuricans intestinal strains to sulfasalazine and its biotransformation products.
2004Medical science monitor : international medical journal of experimental and clinical research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Molecular characterisation of the gut microflora of healthy and inflammatory bowel disease cats using fluorescence in situ hybridisation with special reference to Desulfovibrio spp.
2007Journal of animal physiology and animal nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Interstrain diversity of 2-keto-3-deoxyoctonate content in lipopolysaccharides of Desulfovibrio desulfuricans.
2009Polish journal of microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases.
2002FEMS microbiology ecology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The chemical composition of endotoxin isolated from intestinal strain of Desulfovibrio desulfuricans.
2012TheScientificWorldJournal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Glycomacropeptide is a prebiotic that reduces Desulfovibrio bacteria, increases cecal short-chain fatty acids, and is anti-inflammatory in mice.
2015American journal of physiology. Gastrointestinal and liver physiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Autophagy counters LPS-mediated suppression of lysozyme.
2017Innate immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pretreatment with probiotic Bifico ameliorates colitis-associated cancer in mice: Transcriptome and gut flora profiling.
2018Cancer science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.
2018Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis.
2018Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hydrogen Sulfide as a Toxic Product in the Small-Large Intestine Axis and its Role in IBD Development.
2019Journal of clinical medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association of Alterations in Intestinal Microbiota With Impaired Psychological Function in Patients With Inflammatory Bowel Diseases in Remission.
2020Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary Taxifolin Protects Against Dextran Sulfate Sodium-Induced Colitis via NF-κB Signaling, Enhancing Intestinal Barrier and Modulating Gut Microbiota.
2020Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Analysis of Physiological Parameters of Desulfovibrio Strains from Individuals with Colitis.
2018Open life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prenatal Maternal Stress Exacerbates Experimental Colitis of Offspring in Adulthood.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Recombinant Bifidobacterium longum Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats.
2022Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Protective effect and mechanism of Bifidobacterium bifidum TMC3115 on long-term colitis in mice which exposed to antibiotic in early life].
2022Wei sheng yan jiu = Journal of hygiene research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
TNF ΔARE Pigs: A Translational Crohn's Disease Model.
2023Journal of Crohn's & colitis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis.
2023Frontiers of medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The maca protein ameliorates DSS-induced colitis in mice by modulating the gut microbiota and production of SCFAs.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-κB/MAPK pathway.
2024International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.
2025Behavioral and brain functions : BBF
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Lactation Lactoferrin Deficiency on Intestinal Microbiota in Different Mice Models.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structural characterization of polysaccharides from 'Nanguo' pear and its protective effect against inflammatory bowel disease in mice via modulating gut microbiota.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human gut strains of Desulfovibrio piger exhibit spontaneous induction of multiple prophages.
2025Applied and environmental microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Taraxacum alleviates ulcerative colitis, accompanied by the modulation of gut microbiota and restoration of intestinal barrier integrity.
2026Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Isolation and evaluation of susceptibility to sulphasalazine of Desulfovibrio desulfuricans strains from the human digestive tract.
1997Acta microbiologica Polonica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
5 papersIntestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases?
2013Best practice & research. Clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract.
2015Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Possible synergy effect of hydrogen sulfide and acetate produced by sulfate-reducing bacteria on inflammatory bowel disease development.
2021Journal of advanced research
Relevant review or meta-analysis for the signal-disease area.
Microscopic Methods for Identification of Sulfate-Reducing Bacteria from Various Habitats.
2021International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Desulfovibrio in the Gut: The Enemy within?
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.