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Desulfovibrio

colorectal cancer

Desulfovibrio looks like a credible signal in colorectal cancer, though some caution is still warranted.

Desulfovibrio shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.

desulfovibrio
Credibility score
68
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 68Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

22 papers
Development of methods for the detection and quantification of 7alpha-dehydroxylating clostridia, Desulfovibrio vulgaris, Methanobrevibacter smithii, and Lactobacillus plantarum in human feces.
2005
Clinica chimica acta; international journal of clinical chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer.
2008
Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
On the relationship between sialomucin and sulfomucin expression and hydrogenotrophic microbes in the human colonic mucosa.
2011
PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Shifts in the Fecal Microbiota Associated with Adenomatous Polyps.
2017
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tissue-Associated Bacterial Alterations in Rectal Carcinoma Patients Revealed by 16S rRNA Community Profiling.
2016
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Black Raspberries and Their Anthocyanin and Fiber Fractions Alter the Composition and Diversity of Gut Microbiota in F-344 Rats.
2017
Nutrition and cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice.
2018
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model.
2019
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon.
2020
Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans.
2019
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Structure of the Mucosal and Stool Microbiome in Lynch Syndrome.
2020
Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A clinical nomogram incorporating salivary Desulfovibrio desulfuricans level and oral hygiene index for predicting colorectal cancer.
2021
Annals of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
High-Fat Diet Enhances the Liver Metastasis Potential of Colorectal Cancer through Microbiota Dysbiosis.
2022
Cancers
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiota composition in patients with right- and left-sided colorectal cancer and after curative colectomy, as analyzed by 16S rRNA gene amplicon sequencing.
2022
BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial dynamics with CRC progression: a study of the mucosal microbiota at multiple sites in cancers, adenomatous polyps, and healthy controls.
2023
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of taxonomic changes in the fecal bacteriome associated with colorectal polyps and cancer: potential biomarkers for early diagnosis.
2023
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024
Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Desulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3.
2024
EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.
2025
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation.
2025
Nature metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Baihua Dangen Tang inhibits the peritoneal metastasis of colon cancer by modulating the bacterial metabolite gentisic acid to suppress MDSCs.
2026
Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Potential Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal Cancer.
2025
Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
The Capacity to Produce Hydrogen Sulfide (H2S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome.
2021
Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

21 papers
Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals.
2009
FEMS microbiology ecology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Analysis of the intestinal lumen microbiota in an animal model of colorectal cancer.
2014
PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc+/1638N Mice: Comparisons and Contrasts.
2016
Journal of Cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial Changes and Host Response in F344 Rat Colon Depending on Sex and Age Following a High-Fat Diet.
2018
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Traditional Processed Meat Products Re-designed Towards Inulin-rich Functional Foods Reduce Polyps in Two Colorectal Cancer Animal Models.
2019
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Functional Food Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Inflammatory Colorectal Cancer in Mice.
2021
OncoTargets and therapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus coryniformis MXJ32 administration ameliorates azoxymethane/dextran sulfate sodium-induced colitis-associated colorectal cancer via reshaping intestinal microenvironment and alleviating inflammatory response.
2022
European journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model.
2022
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polysaccharides from Lachnum sp. Inhibited colitis-associated colon tumorigenesis in mice by modulating fecal microbiota and metabolites.
2022
International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Recombinant Bifidobacterium longum Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats.
2022
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Omega-3-Rich Fish-Oil-Influenced Mouse Gut Microbiome Shaped by Intermittent Consumption of Beef.
2023
Current microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal microbiota transplantation inhibits colorectal cancer progression: Reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses.
2023
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of pork sausage on intestinal microecology and metabolism in mice.
2024
Journal of the science of food and agriculture
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites.
2024
BMC cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Probiotic Mixture Attenuates Colorectal Tumorigenesis in Murine AOM/DSS Model by Suppressing STAT3, Inducing Apoptotic p53 and Modulating Gut Microbiota.
2025
Probiotics and antimicrobial proteins
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Chang-Wei-Qing Combined with PD-1 Inhibitor Alleviates Colitis-Associated Colorectal Tumorigenesis by Modulating the Gut Microbiota and Restoring Intestinal Barrier.
2024
Biological procedures online
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Baseline abundance of Akkermansia muciniphila and Bacteroides acidifaciens in a healthy state predicts inflammation associated tumorigenesis in the AOM/DSS mouse model.
2025
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota and metabolic health risks from chronic low-dose microplastic exposure with focus on Desulfovibrio spp.
2025
Ecotoxicology and environmental safety
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Micro-nano microbial fuel cell-driven bioelectrochemical tumor therapy.
2025
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human gut strains of Desulfovibrio piger exhibit spontaneous induction of multiple prophages.
2025
Applied and environmental microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Peptide-functionalized membrane camouflage for endogenous H2S-induced photothermal immunotherapy of orthotopic colorectal cancer.
2026
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

3 papers
Colorectal Cancer, Gut Microbiota and Traditional Chinese Medicine: A Systematic Review.
2021
The American journal of Chinese medicine
Relevant review or meta-analysis for the signal-disease area.
Systematic review: non-endoscopic surveillance for colorectal neoplasia in individuals with Lynch syndrome.
2022
Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Role of sulfidogenic members of the gut microbiota in human disease.
2024
Advances in microbial physiology
Relevant review or meta-analysis for the signal-disease area.