preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtopmoderate inflation risk
Cutibacterium acnes
atopic dermatitis
Cutibacterium acnes is an interesting but still moderate-confidence signal in atopic dermatitis.
Cutibacterium acnes shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
cutibacterium_acnes
Credibility score
54
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 54Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
2 flagsreview_heavy
Review literature is very dense relative to primary central evidence.
Primary central evidence
11 papersSkin Microbiome Differences in Atopic Dermatitis and Healthy Controls in Egyptian Children and Adults, and Association with Serum Immunoglobulin E.
2019Omics : a journal of integrative biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Atopic dermatitis microbiomes stratify into ecologic dermotypes enabling microbial virulence and disease severity.
2021The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of Distinct Microbiota Associated with Scalp Dermatitis in Patients with Atopic Dermatitis.
2022Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Wnt-activating human skin organoid model of atopic dermatitis induced by Staphylococcus aureus and its protective effects by Cutibacterium acnes.
2022iScience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Application of Topical Sandalore® Increases Epidermal Dermcidin Synthesis in Organ-Cultured Human Skin ex vivo.
2023Skin pharmacology and physiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Head and neck dermatitis is exacerbated by Malassezia furfur colonization, skin barrier disruption, and immune dysregulation.
2023Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Investigating Distinct Skin Microbial Communities and Skin Metabolome Profiles in Atopic Dermatitis.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Acid-treated Staphylococcus aureus induces acute silkworm hemolymph melanization.
2024PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Targeting S. aureus Extracellular Vesicles: A New Putative Strategy to Counteract Their Pathogenic Potential.
2024Pharmaceutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics signatures reveal genomic and functional heterogeneity of Cutibacterium acnes in normal and diseased skin.
2024Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A multi-strain human skin microbiome model provides a testbed for disease modeling.
2025Frontiers in microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersSkin dysbiosis in the microbiome in atopic dermatitis is site-specific and involves bacteria, fungus and virus.
2021BMC microbiology
Human primary paper with plausible association relevance to the disease context.
Unique dermal bacterial signature differentiates atopic dermatitis skin from healthy.
2025mSphere
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
13 papersDysbiotic Lesional Microbiome With Filaggrin Missense Variants Associate With Atopic Dermatitis in India.
2020Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan.
2021Dermatopathology (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dupilumab Therapy Improves Stratum Corneum Hydration and Skin Dysbiosis in Patients With Atopic Dermatitis.
2021Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antimicrobial activity of Lactiplantibacillus plantarum APsulloc 331261 and APsulloc 331266 against pathogenic skin microbiota.
2021Frontiers in bioscience (Elite edition)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The potential role for phage therapy for genetic modification of cutaneous diseases.
2022Clinics in dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Potential functionality of Cutibacterium acnes extracellular vesicles in atopic dermatitis and acne vulgaris: A comparative proteomic analysis.
2024Proteomics. Clinical applications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Staphylococcus aureus colonizing the skin microbiota of adults with severe atopic dermatitis exhibits genomic diversity and convergence in biofilm traits.
2024Biofilm
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Associations Between Skin Microbiome and Metabolome in the Pathogenesis of Atopic Dermatitis Patients With Scalp Involvement.
2024Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The inner elbow skin microbiome contains Lactobacillus among its core taxa and varies with age, season and lifestyle.
2024Microbiome research reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The effects of topical antimicrobial-corticosteroid combination therapy in comparison to topical steroids alone on the skin microbiome of patients with atopic dermatitis.
2025The Journal of dermatological treatment
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enhanced Dermal Delivery of Nanoparticulate Formulation of Cutibacterium acnes Using Sponge Spicules for Atopic Dermatitis Treatment.
2025International journal of nanomedicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Systemic Therapies on Skin Bacteriome in Patients with Atopic Dermatitis: A Pilot Prospective Study.
2026The Journal of investigative dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Crisaborole Reduced the Staphylococci but Increased Cutibacterium on the Skin Microbiome of Children with Atopic Dermatitis.
2026Dermatitis : contact, atopic, occupational, drug
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
21 papersSkin microbiota: Friend or foe in pediatric skin health and skin disease.
2019Pediatric dermatology
Relevant review or meta-analysis for the signal-disease area.
Staphylococcus epidermidis and Cutibacterium acnes: Two Major Sentinels of Skin Microbiota and the Influence of Cosmetics.
2020Microorganisms
Relevant review or meta-analysis for the signal-disease area.
From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis.
2021Microorganisms
Relevant review or meta-analysis for the signal-disease area.
[The skin microbiome-useful for diagnosis and therapy?].
2021Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
Relevant review or meta-analysis for the signal-disease area.
Novel mechanisms of microbial crosstalk with skin innate immunity.
2021Experimental dermatology
Relevant review or meta-analysis for the signal-disease area.
Skin microbiome of atopic dermatitis.
2022Allergology international : official journal of the Japanese Society of Allergology
Relevant review or meta-analysis for the signal-disease area.
Evolving approaches to profiling the microbiome in skin disease.
2023Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Markers of Oxidative Stress in Patients with Acne: A Literature Review.
2023Life (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
The Mind Body Connection in Dermatologic Conditions: A Literature Review.
2023Journal of cutaneous medicine and surgery
Relevant review or meta-analysis for the signal-disease area.
Are the Cutaneous Microbiota a Guardian of the Skin's Physical Barrier? The Intricate Relationship between Skin Microbes and Barrier Integrity.
2023International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset?
2024International immunology
Relevant review or meta-analysis for the signal-disease area.
Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease.
2025Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Skin-associated commensal microorganisms and their metabolites.
2025Journal of applied microbiology
Relevant review or meta-analysis for the signal-disease area.
Skin microbiota in atopic dermatitis: victim or executioner?
2025Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
[Skin Microbiome and Dermatitis: Focusing on Two Distinct Skin Diseases, Atopic Dermatitis and Androgenetic Alopecia].
2025Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Relevant review or meta-analysis for the signal-disease area.
The Role of Skin Microbiota in Facial Dermatoses and Related Factors: A Narrative Review.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
From 1D microbiological assays to 3D advanced skin models: enhancing preclinical strategies to unravel the impact of bioactive textiles on the human skin microbiome.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Endogenous Hypersensitivity Infection: A Unifying Framework for Cutibacterium acnes-Associated Sarcoidosis.
2026Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis in the Pathogenesis of Atopic Dermatitis.
2026The Journal of dermatology
Relevant review or meta-analysis for the signal-disease area.
The ecological dynamics of skin microbiota in skin health and diseases.
2026Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
Postbiotics in Dermatology: A Literature Review of Emerging Topical Therapies for Acne, Rosacea, and Eczema.
2026Cureus
Relevant review or meta-analysis for the signal-disease area.