preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Corynebacterium
atopic dermatitis
Corynebacterium has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Corynebacterium shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
corynebacterium
Credibility score
42
Human translation
2/5
Reproducibility
4/5
Novelty
3/5
Actionability
2/5
Credibility 42Human translation 2/5Reproducibility 4/5Novelty 3/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
9 papersPattern of bacterial colonization of atopic dermatitis in saudi children.
2013Journal of clinical and diagnostic research : JCDR
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.
2015Immunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Nasal and conjunctival screening prior to refractive surgery: an observational and cross-sectional study.
2016BMJ open
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of an Emollient on the Mycobiome of Atopic Dermatitis Patients.
2018Journal of drugs in dermatology : JDD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Skin Microbiome Differences in Atopic Dermatitis and Healthy Controls in Egyptian Children and Adults, and Association with Serum Immunoglobulin E.
2019Omics : a journal of integrative biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the skin microbiome are associated with disease severity and treatment in the perioral zone of the skin of infants with atopic dermatitis.
2019European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Co-occurrence network analysis reveals the alterations of the skin microbiome and metabolome in adults with mild to moderate atopic dermatitis.
2024mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An Observational Study: Association Between Atopic Dermatitis and Bacterial Colony of the Skin Based on 16S rRNA Gene Sequencing.
2024Clinical, cosmetic and investigational dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial IgA coating in infants with traditional farming lifestyle and urban infants with allergic outcomes.
2026Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
6 papersMicrobiome analysis of forehead skin in patients with atopic dermatitis and healthy subjects: Implication of Staphylococcus and Corynebacterium.
2018The Journal of dermatology
Human primary paper with plausible association relevance to the disease context.
Initial Evidence of Distinguishable Bacterial and Fungal Dysbiosis in the Skin of Patients with Atopic Dermatitis or Netherton Syndrome.
2021The Journal of investigative dermatology
Human primary paper with plausible association relevance to the disease context.
Distinct Skin Microbiota Imbalance and Responses to Clinical Treatment in Children With Atopic Dermatitis.
2020Frontiers in cellular and infection microbiology
Human primary paper with plausible association relevance to the disease context.
Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population.
2022Journal of dermatological science
Human primary paper with plausible association relevance to the disease context.
Unique dermal bacterial signature differentiates atopic dermatitis skin from healthy.
2025mSphere
Human primary paper with plausible association relevance to the disease context.
Delayed skin reaction to human dander in atopic dermatitis.
1969Acta dermato-venereologica
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
16 papersA high incidence of Staphylococcus aureus colonization in the external eyes of patients with atopic dermatitis.
2000Ophthalmology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Long-term treatment of atopic dermatitis with pimecrolimus cream 1% in infants does not interfere with the development of protective antibodies after vaccination.
2005Journal of the American Academy of Dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Microecological and electron microscopic study of skin microbiota in patients with atopic dermatitis].
2010Zhurnal mikrobiologii, epidemiologii i immunobiologii
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Assessment of a contact-plate sampling technique and subsequent quantitative bacterial studies in atopic dermatitis.
1990The British journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis.
2012Genome research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeting IL-23 by employing a p40 peptide-based vaccine ameliorates murine allergic skin and airway inflammation.
2012Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The altered landscape of the human skin microbiome in patients with primary immunodeficiencies.
2013Genome research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Longitudinal Evaluation of the Skin Microbiome and Association with Microenvironment and Treatment in Canine Atopic Dermatitis.
2016The Journal of investigative dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Deleterious Effects of an Air Pollutant (NO2) on a Selection of Commensal Skin Bacterial Strains, Potential Contributor to Dysbiosis?
2020Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical cream containing live lactobacilli decreases malodor-producing bacteria and downregulates genes encoding PLP-dependent enzymes on the axillary skin microbiome of healthy adult Nigerians.
2021Journal of cosmetic dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dupilumab Therapy Improves Stratum Corneum Hydration and Skin Dysbiosis in Patients With Atopic Dermatitis.
2021Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative Genomic and Metagenomic Investigations of the Corynebacterium tuberculostearicum Species Complex Reveals Potential Mechanisms Underlying Associations To Skin Health and Disease.
2023Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alterations of Epidermal Lipid Profiles and Skin Microbiome in Children With Atopic Dermatitis.
2023Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical administration of coumarin derivatives alleviates skin inflammatory symptoms in atopic dermatitis model.
2025Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Systemic Therapies on Skin Bacteriome in Patients with Atopic Dermatitis: A Pilot Prospective Study.
2026The Journal of investigative dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Thuja sutchuenensis Franch. Essential Oil Ameliorates Atopic Dermatitis Symptoms in Mice by Modulating Skin Microbiota Composition and Reducing Inflammation.
2025Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersThe immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update.
2023Frontiers in molecular biosciences
Relevant review or meta-analysis for the signal-disease area.
Skin microbiota in atopic dermatitis: victim or executioner?
2025Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
[Skin Microbiome and Dermatitis: Focusing on Two Distinct Skin Diseases, Atopic Dermatitis and Androgenetic Alopecia].
2025Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Relevant review or meta-analysis for the signal-disease area.
Skin bacteriology and the role of Staphylococcus aureus in infection.
1998The British journal of dermatology
Relevant review or meta-analysis for the signal-disease area.