Effect of Vitamin D Supplementation on Faecal Microbiota: A Randomised Clinical Trial.
2019Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Coprococcus
obesity
Coprococcus appears to be a strong and relatively human-grounded signal in obesity.
Coprococcus shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
coprococcus
Credibility score
85
Human translation
5/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 85Human translation 5/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
Main caveats
- directionality and confounding still require curated review
Primary central evidence
29 papersCharacteristic gut microbiota and predicted metabolic functions in women with PCOS.
2020Endocrine connections
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of Gut Microbiota Composition in Hemodialysis Patients With Normal Weight Obesity.
2020The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Short-term high-intensity interval training exercise does not affect gut bacterial community diversity or composition of lean and overweight men.
2020Experimental physiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation Between Fecal Metabolomics and Gut Microbiota in Obesity and Polycystic Ovary Syndrome.
2020Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Pregnant women who develop preeclampsia have lower abundance of the butyrate-producer Coprococcus in their gut microbiota.
2021Pregnancy hypertension
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lean and obese microbiota: differences in in vitro fermentation of food-by-products.
2021Beneficial microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota, Glucose, Lipid, and Water-Electrolyte Metabolism in Children With Nonalcoholic Fatty Liver Disease.
2021Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity.
2021Genome biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A High Protein Diet Is More Effective in Improving Insulin Resistance and Glycemic Variability Compared to a Mediterranean Diet-A Cross-Over Controlled Inpatient Dietary Study.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Association between obesity with the diversity and genus of gut microbiota in school-aged children].
2022Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and acylcarnitine metabolites connect the beneficial association between equol and adiposity in adults: a prospective cohort study.
2022The American journal of clinical nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific gut bacterial and fungal microbiota pattern in the first half of pregnancy is linked to the development of gestational diabetes mellitus in the cohort including obese women.
2022Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Synbiotic Supplementation Modulates Gut Microbiota, Regulates β-Catenin Expression and Prevents Weight Gain in ob/ob Mice: Preliminary Findings.
2022International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of faecal microbial transplant via colonoscopy in patients with severe obesity and insulin resistance: A randomized double-blind, placebo-controlled Phase 2 trial.
2023Diabetes, obesity & metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Was Reshaped in UCP1 Knock-In Pigs via the Adipose-Liver-Gut Axis and Contributed to Less Fat Deposition.
2023Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Serum Metabolites in Individuals with Class III Obesity Without Type 2 Diabetes Mellitus: Pilot Analysis.
2023Metabolic syndrome and related disorders
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying Gut Microbiota associated with Gastrointestinal Symptoms upon Roux-en-Y Gastric Bypass.
2023Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomics study on taxonomic and functional change of gut microbiota in patients with obesity with PCOS treated with exenatide combination with metformin or metformin alone.
2023Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Take-out food enhances the risk of MPs ingestion and obesity, altering the gut microbiome in young adults.
2024Journal of hazardous materials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diet and the Gut Microbiome as Determinants Modulating Metabolic Outcomes in Young Obese Adults.
2024Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary Antrodia cinnamomea Polysaccharide Intervention Modulates Clinical Symptoms by Regulating Ovarian Metabolites and Restructuring the Intestinal Microbiota in Rats with Letrozole-Induced PCOS.
2024Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and metabolic responses to a 12-week caloric restriction combined with strength and HIIT training in patients with obesity: a randomized trial.
2024BMC sports science, medicine & rehabilitation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific dietary fibers steer toward distal colonic saccharolytic fermentation using the microbiota of individuals with overweight/obesity.
2025Food research international (Ottawa, Ont.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Theaflavins in black tea ameliorate high-fat diet-induced obesity and inflammation via gut microbiota, AMPK-mediated metabolism, and NF-κB pathway.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A species of Coprococcus is related to BMI in patients who underwent malabsorptive bariatric surgery and its abundance is modified by magnesium and thiamin intake.
2025Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota composition and derived enterotypes are associated with ponderal status in preschool children. Childhood obesity risk assessment longitudinal study (CORALS) cohort.
2026Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersEffect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study.
2021The American journal of clinical nutrition
Human primary paper with plausible association relevance to the disease context.
The association between gut microbiota and metabolic dysfunction-associated steatotic liver disease (MASLD): a case-control study.
2025BMC pediatrics
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
7 papersAnalysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador.
2020Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eicosapentaenoic and Docosahexaenoic Acids Differentially Alter Gut Microbiome and Reverse High-Fat Diet-Induced Insulin Resistance.
2020Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alteration of Gut Microbiota Relates to Metabolic Disorders in Primary Aldosteronism Patients.
2021Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association of Gut Microbiota with Dietary-dependent Childhood Obesity.
2022Archives of medical research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Functional Fiber Reduces Mice Obesity by Regulating Intestinal Microbiota.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Probiotic-fermented tomato alleviates high-fat diet-induced obesity in mice: Insights from microbiome and metabolomics.
2024Food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Composition of gut microbiota in obese and normal-weight Uygur adults and its association with adipocyte-related factors.
2024Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
9 papersModulation of the gut microbiome: a systematic review of the effect of bariatric surgery.
2018European journal of endocrinology
Relevant review or meta-analysis for the signal-disease area.
An association between chronic widespread pain and the gut microbiome.
2021Rheumatology (Oxford, England)
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review.
2022Reproductive sciences (Thousand Oaks, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Targeting the Gut Microbiome to Treat Metabolic Dysfunction-Associated Fatty Liver Disease: Ready for Prime Time?
2022Cells
Relevant review or meta-analysis for the signal-disease area.
Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Effect of Plant-Based Diets on Gut Microbiota: A Systematic Review of Interventional Studies.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
How important are fatty acids in human health and can they be used in treating diseases?
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Distinct Gut Microbiota Profiles in Normal Weight Obesity and Their Association With Cardiometabolic Diseases: Results From Two Independent Cohort Studies.
2025Journal of cachexia, sarcopenia and muscle
Relevant review or meta-analysis for the signal-disease area.
Diet and the gut microbiota profiles in individuals at risk of chronic heart failure - A review on the Asian population.
2025Asia Pacific journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.