sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Coprococcus
inflammatory bowel disease
Coprococcus looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Coprococcus shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
coprococcus
Credibility score
62
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 62Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
22 papersAssociation of symptoms with gastrointestinal microbiota in irritable bowel syndrome.
2010World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of fecal and mucosa-associated microbiota in Chinese patients with inflammatory bowel disease.
2014Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease.
2015Arthritis & rheumatology (Hoboken, N.J.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.
2016Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of Enteric Microbiota in Patients with a Normal Ileal Pouch Are Predictive of Pouchitis.
2017Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease.
2018Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.
2018PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?
2018Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn's Disease: Results from the IMPACT Study.
2020Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Attributes of intestinal microbiota composition and their correlation with clinical primary non-response to anti-TNF-α agents in inflammatory bowel disease patients.
2022Bosnian journal of basic medical sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis in the Gut Microbiota in Patients with Inflammatory Bowel Disease during Remission.
2022Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lactobacillus plantarum MH-301 as an effective adjuvant to isotretinoin in the treatment of acne vulgaris: a randomized and open-label trail.
2023Frontiers in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal Bacteroides thetaiotaomicron.
2025mBio
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Fecal Microbiome of IBD Patients Is Less Divertible by Bowel Preparation Compared to Healthy Controls: Results From a Prospective Study.
2025Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploring the role of gut microbiota in inflammatory bowel disease patients comorbid with non-alcoholic fatty liver disease.
2025Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Geography-independent mucosal microbiota alterations in primary sclerosing cholangitis persist after liver transplantation.
2026JHEP reports : innovation in hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial and fungal biomarkers in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD): trans-kingdom interactions, Blastocystis carriage, and enterotype-succinotype stratification.
2026Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and bile acids profiles study of ulcerative colitis and Crohn's disease patients.
2026Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
11 papersEffects of dietary tryptophan supplementation in the acetic acid-induced colitis mouse model.
2018Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ultraviolet Irradiation of Skin Alters the Faecal Microbiome Independently of Vitamin D in Mice.
2018Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis.
2018Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tilapia head glycolipids reduce inflammation by regulating the gut microbiota in dextran sulphate sodium-induced colitis mice.
2020Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
2020Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protein diets with the role of immune and gut microbial regulation alleviate DSS-induced chronic ulcerative colitis.
2021Food science & nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Two-Sample Mendelian Randomization Analysis Investigates Causal Associations Between Gut Microbial Genera and Inflammatory Bowel Disease, and Specificity Causal Associations in Ulcerative Colitis or Crohn's Disease.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coprococcus eutactus, a Potent Probiotic, Alleviates Colitis via Acetate-Mediated IgA Response and Microbiota Restoration.
2023Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation.
2024Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii Induces an Anti-inflammatory Response and a Metabolic Reprogramming in Human Monocytes.
2026Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Selected bacterial antibodies in Crohn's disease and ulcerative colitis.
1983Scandinavian journal of gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersGut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review.
2021Frontiers in pediatrics
Relevant review or meta-analysis for the signal-disease area.
Gut bacteriome in inflammatory bowel disease: An update on recent advances.
2024Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome remodeling induced by microplastic exposure in humans.
2026Gut microbes
Relevant review or meta-analysis for the signal-disease area.