Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.
2010World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Coprococcus
crohn's disease
Coprococcus appears to be a strong and relatively human-grounded signal in crohn's disease.
Coprococcus shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
coprococcus
Credibility score
82
Human translation
4/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 82Human translation 4/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Primary central evidence
29 papersCharacteristics of fecal and mucosa-associated microbiota in Chinese patients with inflammatory bowel disease.
2014Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease.
2015Arthritis & rheumatology (Hoboken, N.J.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of Enteric Microbiota in Patients with a Normal Ileal Pouch Are Predictive of Pouchitis.
2017Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease.
2018Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.
2018PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?
2018Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial dysbiosis in inflammatory bowel diseases: results of a metagenomic study in Saudi Arabia.
2019Minerva gastroenterologica e dietologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn's Disease: Results from the IMPACT Study.
2020Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Induction of chronic arthritis in rats by cell wall fragments of anaerobic coccoid rods isolated from the faecal flora of patients with Crohn's disease.
1988Digestion
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal Microbiota Composition Varies between Patients with Breast Cancer and Healthy Women: A Comparative Case-Control Study.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal microbiota changes induced by TNF-inhibitors in IBD-related spondyloarthritis.
2021RMD open
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Attributes of intestinal microbiota composition and their correlation with clinical primary non-response to anti-TNF-α agents in inflammatory bowel disease patients.
2022Bosnian journal of basic medical sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary inflammatory potential mediated gut microbiota and metabolite alterations in Crohn's disease: A fire-new perspective.
2022Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis in the Gut Microbiota in Patients with Inflammatory Bowel Disease during Remission.
2022Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Increased faecal glycosidases in patients with Crohn's disease.
1987Digestion
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in the early stage of Crohn's disease has unique characteristics.
2022Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Antibodies to Coprococcus comes in sera of patients with Crohn's disease. Isolation and purification of the agglutinating antigen tested with an ELISA technique.
1987Journal of clinical & laboratory immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial signatures and their functions in Behcet's uveitis and Vogt-Koyanagi-Harada disease.
2023Journal of autoimmunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lactobacillus plantarum MH-301 as an effective adjuvant to isotretinoin in the treatment of acne vulgaris: a randomized and open-label trail.
2023Frontiers in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Binding of Coprococcus comes to the Fc portion of IgG. A possible role in the pathogenesis of Crohn's disease?
1985European journal of immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal Bacteroides thetaiotaomicron.
2025mBio
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Fecal Microbiome of IBD Patients Is Less Divertible by Bowel Preparation Compared to Healthy Controls: Results From a Prospective Study.
2025Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Induction in rats of serum agglutinins to Eubacterium, Peptostreptococcus and Coprococcus species by the faecal flora from patients with Crohn's disease and healthy subjects.
1984The Journal of hygiene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Serodiagnosis of Crohn's disease].
1983Deutsche medizinische Wochenschrift (1946)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersGenome sequence and description of Coprococcus phoceensis gen. nov., sp. nov., a new bacterial genus isolated from the human left colon.
2019New microbes and new infections
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
14 papersUltraviolet Irradiation of Skin Alters the Faecal Microbiome Independently of Vitamin D in Mice.
2018Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis.
2018Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tilapia head glycolipids reduce inflammation by regulating the gut microbiota in dextran sulphate sodium-induced colitis mice.
2020Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
2020Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protein diets with the role of immune and gut microbial regulation alleviate DSS-induced chronic ulcerative colitis.
2021Food science & nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Two-Sample Mendelian Randomization Analysis Investigates Causal Associations Between Gut Microbial Genera and Inflammatory Bowel Disease, and Specificity Causal Associations in Ulcerative Colitis or Crohn's Disease.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacterium longum CECT 7894 Improves the Efficacy of Infliximab for DSS-Induced Colitis via Regulating the Gut Microbiota and Bile Acid Metabolism.
2022Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coprococcus eutactus, a Potent Probiotic, Alleviates Colitis via Acetate-Mediated IgA Response and Microbiota Restoration.
2023Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Culturing and extraction of Coprococcus comes, absorption of serumagglutinins by soluble fractions and relation between agglutinins and antibodies in sera of patients with Crohn's disease.
1986Medical microbiology and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation.
2024Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antibody response to anaerobic coccoid rods in Crohn's disease.
1986Journal of clinical pathology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative metagenomics reveals the differential gut microbiota involved in bile acid metabolism in patients with crohn's disease.
2025World journal of microbiology & biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii Induces an Anti-inflammatory Response and a Metabolic Reprogramming in Human Monocytes.
2026Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
An international study of agglutinins to Eubacterium, Peptostreptococcus and Coprococcus species in Crohn's disease, ulcerative colitis and control subjects.
1983Digestion
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersGut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review.
2021Frontiers in pediatrics
Relevant review or meta-analysis for the signal-disease area.
Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Gut bacteriome in inflammatory bowel disease: An update on recent advances.
2024Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.