Composition, Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes.
2015Journal of diabetes and obesity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Collinsella aerofaciens
type 2 diabetes
Collinsella aerofaciens looks like a credible signal in type 2 diabetes, though some caution is still warranted.
Collinsella aerofaciens shows a strong literature footprint in type 2 diabetes, with substantial central evidence and broader supporting literature.
collinsella_aerofaciens
Credibility score
61
Human translation
5/5
Reproducibility
4/5
Novelty
3/5
Actionability
4/5
Credibility 61Human translation 5/5Reproducibility 4/5Novelty 3/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
Main caveats
- directionality and confounding still require curated review
Primary central evidence
22 papersModulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet.
2016The British journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum.
2018Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: A pilot study.
2019PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans.
2020Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Insights into the gut microbiota of Nigerian elderly with type 2 diabetes and non-diabetic elderly persons.
2020Heliyon
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes.
2021European journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects.
2020Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Could dysbiosis of inflammatory and anti-inflammatory gut bacteria have an implications in the development of type 2 diabetes? A pilot investigation.
2021BMC research notes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition and diversity of gut microbiota in diabetic retinopathy.
2022Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Similar bacterial signatures in the gut microbiota of type 1 and type 2 diabetes patients and its association with G protein-coupled receptor 41 and 43 gene expression.
2022Journal of diabetes and metabolic disorders
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Bacterial Community and Metagenome Function in Asians with Type 2 Diabetes, According to Enterotypes.
2022Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of the Serum Microbiota and Circulating Metabolites in Cynomolgus Monkeys With Spontaneous Type 2 Diabetes Mellitus.
2024Journal of medical primatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interactions between the gut microbiome and DNA methylation patterns in blood and visceral adipose tissue in subjects with different metabolic characteristics.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal Microbiota Composition in Patients with Type 2 Diabetes and Effects of Oral Antidiabetics.
2025Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of children's microbiota on adipose and intestinal development in sex-matched mice persist into adulthood following a single fecal microbiota transplantation.
2025Molecular metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes of intestinal microbiome and its relationship with painful diabetic neuropathy in rats.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Comparison of the Gut Microbiome Composition, Serum Inflammatory Markers and Faecal Short-Chain Fatty Acids Among Individuals With Type 1 and 2 Diabetes Mellitus With Healthy Controls: A Case-Control Study.
2025Endocrinology, diabetes & metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated analysis of gut microbiota, fecal and serum metabolites in type 2 diabetes mellitus with peripheral neuropathy.
2025Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The intestinal microbiota of patients with type 2 diabetes is associated with the C-512T polymorphism of the FOXC2 gene.
2025Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Investigating gut microbiome dysbiosis in adults with chronic kidney disease: Diabetes-induced alterations via metagenomics and qPCR.
2026Life sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Dyslipidemia in Type 2 Diabetes: A Pilot Study of 16S rRNA Profiles and Predicted Functional Shifts.
2026Journal of diabetes research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersGut-derived bacterial membrane vesicles in prediabetes: Vesicle composition dictates inflammatory properties.
2026iScience
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
6 papersInsulin Resistance, Microbiota, and Fat Distribution Changes by a New Model of Vertical Sleeve Gastrectomy in Obese Rats.
2016Diabetes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characteristics of Gastric Microbiota in GK Rats with Spontaneous Diabetes: A Comparative Study.
2020Diabetes, metabolic syndrome and obesity : targets and therapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Longitudinal analysis of the rectal microbiome in dogs with diabetes mellitus after initiation of insulin therapy.
2022PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alterations of the gut microbiota in type 2 diabetics with or without subclinical hypothyroidism.
2023PeerJ
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiota dysbiosis associated with type 2 diabetes-like effects caused by chronic exposure to a mixture of chlorinated persistent organic pollutants in zebrafish.
2023Environmental pollution (Barking, Essex : 1987)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Neuroactive Steroid-Gut Microbiota Interaction in T2DM Diabetic Encephalopathy.
2023Biomolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
2 papersCharacteristics of the gut microbiome in women with gestational diabetes mellitus: A systematic review.
2022PloS one
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Composition in Prediabetes and Newly Diagnosed Type 2 Diabetes: A Systematic Review of Observational Studies.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.