Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.
2010World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
supportedmidmoderate inflation risk
Collinsella aerofaciens
inflammatory bowel disease
Collinsella aerofaciens is an interesting but still moderate-confidence signal in inflammatory bowel disease.
Collinsella aerofaciens shows a moderate evidence base in inflammatory bowel disease, with multiple central papers and additional supporting literature.
collinsella_aerofaciens
Credibility score
30
Human translation
4/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 30Human translation 4/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
Main caveats
- directionality and confounding still require curated review
Primary central evidence
11 papersOral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD.
2017Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Low-complexity microbiota in the duodenum of children with newly diagnosed ulcerative colitis.
2017PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Seasonal changes of circulating 25-hydroxyvitamin D correlate with the lower gut microbiome composition in inflammatory bowel disease patients.
2020Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations.
2020Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clinical response and changes in the fecal microbiota and metabolite levels after fecal microbiota transplantation in patients with inflammatory bowel disease and recurrent Clostridioides difficile infection.
2021Fujita medical journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Deciphering Microbial Composition in Patients with Inflammatory Bowel Disease: Implications for Therapeutic Response to Biologic Agents.
2024Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis.
2024Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Culture-based characterization of gut microbiota in inflammatory bowel disease.
2025Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tissue and stool microbiome in pediatric inflammatory bowel disease patients: diversity differs in patients with relapsing and non-relapsing Crohn's disease.
2025Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Development of a prognostic model for sepsis based on gut microbiota-associated genes and identification of potential targets.
2026Frontiers in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
4 papersHumoral immune responses against gut bacteria in dogs with inflammatory bowel disease.
2019PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn's disease patients versus mucus.
2020Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prebiotics effects in vitro of polysaccharides from tea flowers on gut microbiota of healthy persons and patients with inflammatory bowel disease.
2020International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces.
2022Science translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
3 papersGut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach.
2025Journal of health, population, and nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome remodeling induced by microplastic exposure in humans.
2026Gut microbes
Relevant review or meta-analysis for the signal-disease area.