review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Clostridioides difficile
ulcerative colitis
Clostridioides difficile looks like a credible signal in ulcerative colitis, though some caution is still warranted.
Clostridioides difficile shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.
clostridioides_difficile
Credibility score
81
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 81Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
2 flagssparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
Primary central evidence
21 papersLongitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis.
2018PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Systemic Inflammatory Responses in Ulcerative Colitis Patients and Clostridium difficile Infection.
2018Digestive diseases and sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clostridium difficile isolated from faecal samples in patients with ulcerative colitis.
2019BMC infectious diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Colectomy Rates Are Increasing Among Inpatients With Concomitant Ulcerative Colitis and Clostridioides difficile.
2021Journal of clinical gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decreased secondary faecal bile acids in children with ulcerative colitis and Clostridioides difficile infection.
2021Alimentary pharmacology & therapeutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with concurrent ulcerative colitis.
2021Acta microbiologica et immunologica Hungarica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Blastocystis and Clostridioides difficile: Evidence for a Synergistic Role in Colonization Among IBD Patients with Emphasis on Ulcerative Colitis.
2021The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Retrospective analysis of Clostridioides difficile and other intestinal infections in patients with Crohn's disease and ulcerative colitis in the tertiary hospital in Poland. POLIBD survey results.
2021Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Metabolite Changes in Patients With Ulcerative Colitis and Clostridioides difficile Infection.
2022Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Clostridioides difficile infection in patients admitted with ulcerative colitis.
2023Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with concurrent ulcerative colitis.
2023Journal of autoimmunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Low prevalence of Clostridioides difficile infection in acute severe ulcerative colitis: A retrospective cohort study from northern India.
2023Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
AGA Clinical Practice Guideline on Fecal Microbiota-Based Therapies for Select Gastrointestinal Diseases.
2024Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fidaxomicin for Clostridioides difficile infection in patients with inflammatory bowel disease: a multicenter retrospective cohort study.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Clostridioides difficile Infection on the Outcome of Severe Flare of Ulcerative Colitis.
2025Journal of clinical gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lactococcus lactis and Bifidobacterium longum attenuate Clostridioides difficile- or Clostridium symbiosum-induced colitis and depression/anxiety-like behavior in male mice.
2025Microbes and infection
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Examining the role of fecal microbiota transplantation for inducing remission in resistant ulcerative proctitis and distal ulcerative colitis (ulcerative proctitis-fecal microbiota transplantation).
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Cross-species engraftment biases and metabolic divergence in gnotobiotic mice humanized with ulcerative colitis microbiota.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of risk factors for Clostridioides difficile infection in patients with ulcerative colitis and development of a predictive nomogram.
2025BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Risk of intestinal complications, extraintestinal morbidity, and mortality in patients with ulcerative colitis and ocular involvement.
2026Eye (London, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
5 papersStudy of the gut microbiome in Egyptian patients with active ulcerative colitis.
2023Revista de gastroenterologia de Mexico (English)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Clinical and Endoscopic Outcomes Through 78 Weeks of Tofacitinib Therapy for Ulcerative Colitis in a US Cohort.
2024Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association Between Smoking Status and the Efficacy and Safety of Tofacitinib in Patients with Ulcerative Colitis.
2024Crohn's & colitis 360
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Impact of vancomycin and Clostridioides difficile on the secretome and pathogenicity of Clostridium innocuum.
2025Medical microbiology and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ustekinumab versus vedolizumab and ustekinumab versus tumor necrosis factor alpha agent infectious adverse effects in patients with ulcerative colitis, a real-world data study.
2025Expert opinion on pharmacotherapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
32 papersPseudomembranous colitis complicating ulcerative colitis.
2010Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Relevant review or meta-analysis for the signal-disease area.
Fulminant colitis.
2013Best practice & research. Clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
[Fecal microbiota transplantation].
2015Gastroenterologia y hepatologia
Relevant review or meta-analysis for the signal-disease area.
Factors precipitating acute ulcerative colitis.
2014Tropical gastroenterology : official journal of the Digestive Diseases Foundation
Relevant review or meta-analysis for the signal-disease area.
The impact of Clostridum difficile on surgical rate among ulcerative colitis patients: A systemic review and meta-analysis.
2015Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Relevant review or meta-analysis for the signal-disease area.
Faecal microbiota transplantation-A clinical view.
2016International journal of medical microbiology : IJMM
Relevant review or meta-analysis for the signal-disease area.
Fecal Microbiota-based Therapeutics for Recurrent Clostridium difficile Infection, Ulcerative Colitis and Obesity.
2016EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Clinical Application and Potential of Fecal Microbiota Transplantation.
2019Annual review of medicine
Relevant review or meta-analysis for the signal-disease area.
[Ulcerative colitis: Does the modulation of gut microbiota induce long-lasting remission?].
2019Zeitschrift fur Gastroenterologie
Relevant review or meta-analysis for the signal-disease area.
Fecal microbiota transplantation in ulcerative colitis.
2019Acta gastro-enterologica Belgica
Relevant review or meta-analysis for the signal-disease area.
MICROBIOTA INSIGHTS IN CLOSTRIDIUM DIFFICILE INFECTION AND INFLAMMATORY BOWEL DISEASE.
2020Gut microbes
Relevant review or meta-analysis for the signal-disease area.
When to use probiotics in luminal gastrointestinal disorders?
2020Current opinion in clinical nutrition and metabolic care
Relevant review or meta-analysis for the signal-disease area.
Phage Therapy in Gastrointestinal Diseases.
2020Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Fecal Microbiota Transplantation for Ulcerative Colitis. Are We Ready for Primetime?
2020Gastroenterology clinics of North America
Relevant review or meta-analysis for the signal-disease area.
Diagnosis and management of Clostridioides difficile infection in patients with inflammatory bowel disease.
2021Current opinion in gastroenterology
Relevant review or meta-analysis for the signal-disease area.
The interplay of Clostridioides difficile infection and inflammatory bowel disease.
2021Therapeutic advances in gastroenterology
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota and gut disease.
2021Internal medicine journal
Relevant review or meta-analysis for the signal-disease area.
Histological features of Clostridioides difficile colitis in patients with inflammatory bowel disease.
2022Histopathology
Relevant review or meta-analysis for the signal-disease area.
Risk Factors, Diagnosis, and Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
[Clostridioides Infection in Patients with Inflammatory Bowel Disease].
2022The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Relevant review or meta-analysis for the signal-disease area.
Fecal Microbiota Transplantation.
2023Clinics in colon and rectal surgery
Relevant review or meta-analysis for the signal-disease area.
Clostridium difficile in inflammatory bowel disease.
2023Current opinion in gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease.
2023Current gastroenterology reports
Relevant review or meta-analysis for the signal-disease area.
Clostridioides difficile Infection in Inflammatory Bowel Disease Patients: A Systematic Review of Risk Factors and Approach in Management.
2023Cureus
Relevant review or meta-analysis for the signal-disease area.
Phage therapy in gut microbiome.
2023Progress in molecular biology and translational science
Relevant review or meta-analysis for the signal-disease area.
Primary clostridium difficile infection in patients with ulcerative colitis: Case report and literature review.
2024Medicine
Relevant review or meta-analysis for the signal-disease area.
The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines.
2024Gut
Relevant review or meta-analysis for the signal-disease area.
Insights into Gut Dysbiosis: Inflammatory Diseases, Obesity, and Restoration Approaches.
2024International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Precision microbiota therapy for IBD: premise and promise.
2025Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Modulation in IBD: From the Old Paradigm to Revolutionary Tools.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Fecal microbiota transfer to treat ulcerative colitis: Medical and legal challenges.
2023Frontiers in gastroenterology (Lausanne, Switzerland)
Relevant review or meta-analysis for the signal-disease area.