review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Clostridioides difficile
obesity
Clostridioides difficile looks like a credible signal in obesity, though some caution is still warranted.
Clostridioides difficile shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
clostridioides_difficile
Credibility score
64
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
4/5
Credibility 64Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
16 papersThe intestinal microbiota composition and weight development in children: the KOALA Birth Cohort Study.
2015International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiome.
2017Australian family physician
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Pet Ownership Protects Against Recurrence of Clostridioides difficile Infection.
2020Open forum infectious diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clostridioides difficile infection after cardiac surgery: Assessment of prevalence, risk factors and clinical outcomes-retrospective study.
2020PeerJ
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Morbid Obesity Increases 30-Day Readmission and Morbidity in Clostridiodes difficile Infection.
2021Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Transplantation beyond Clostridioides Difficile Infection.
2021Clinical endoscopy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Novel risk factors and outcomes in inflammatory bowel disease patients with Clostridioides difficile infection.
2021Therapeutic advances in gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The outcomes of Clostridioides difficile infection in inpatient liver transplant population.
2022Transplant infectious disease : an official journal of the Transplantation Society
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Obesity is not associated with adverse outcomes among hospitalized patients with Clostridioides difficile infection.
2022Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Concomitance of COVID-19 and legionnaires' disease - a case series.
2022Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of human microbiome and infectious diseases.
2022Progress in molecular biology and translational science
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Transplantation in Patients Co-Infected with SARS-CoV2 and Clostridioides difficile.
2022Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predictors of prolonged hospitalization of COVID-19 patients.
2023European geriatric medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Colon Cancer Risk Following Intestinal Clostridioides difficile Infection: A Longitudinal Cohort Study.
2023Journal of clinical medicine research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Standards for fecal microbiota transplant: Tools and therapeutic advances.
2024Biologicals : journal of the International Association of Biological Standardization
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Detecting and mitigating doppelgänger bias in microbiome data: impacts on machine learning and disease classification.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersNon-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship?
2024BMC pediatrics
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
4 papersObeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice.
2021Mucosal immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
From Birth to Overweight and Atopic Disease: Multiple and Common Pathways of the Infant Gut Microbiome.
2021Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Caloric restriction disrupts the microbiota and colonization resistance.
2021Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Epigallocatechin-3-Gallate Improves Intestinal Gut Microbiota Homeostasis and Ameliorates Clostridioides difficile Infection.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
27 papersFecal microbiota transplantation: past, present and future.
2013Current opinion in gastroenterology
Relevant review or meta-analysis for the signal-disease area.
[The intestinal microbiota and human disease].
2013The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Relevant review or meta-analysis for the signal-disease area.
Therapeutic potential of fecal microbiota transplantation.
2013Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
A clinician's primer on the role of the microbiome in human health and disease.
2014Mayo Clinic proceedings
Relevant review or meta-analysis for the signal-disease area.
Role of obesity and adipose tissue-derived cytokine leptin during Clostridium difficile infection.
2015Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Recurrent Clostridium difficile infection and the microbiome.
2016Journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Faecal microbiota transplantation-A clinical view.
2016International journal of medical microbiology : IJMM
Relevant review or meta-analysis for the signal-disease area.
Fecal Microbiota-based Therapeutics for Recurrent Clostridium difficile Infection, Ulcerative Colitis and Obesity.
2016EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Therapies to modulate gut microbiota: Past, present and future.
2020World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Bacteriophage-mediated manipulation of the gut microbiome - promises and presents limitations.
2020FEMS microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
[Probiotics: benefits and harms].
2020Revue medicale suisse
Relevant review or meta-analysis for the signal-disease area.
Bile Acids and Microbiota: Multifaceted and Versatile Regulators of the Liver-Gut Axis.
2021International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Significance of the Gut Microbiome for Viral Diarrheal and Extra-Intestinal Diseases.
2021Viruses
Relevant review or meta-analysis for the signal-disease area.
Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis.
2022Infection
Relevant review or meta-analysis for the signal-disease area.
Encapsulated Fecal Microbiota Transplantation: Development, Efficacy, and Clinical Application.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases.
2022Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Relevant review or meta-analysis for the signal-disease area.
Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols.
2022Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
[Fecal Microbiota Transplants in the Context of (Child and Adolescent) Psychiatric Disorders].
2023Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
Relevant review or meta-analysis for the signal-disease area.
Anaerobes in specific infectious and noninfectious diseases: new developments.
2023Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Human intestinal microbiome: Role in health and disease.
2024Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
Relevant review or meta-analysis for the signal-disease area.
Insights into Gut Dysbiosis: Inflammatory Diseases, Obesity, and Restoration Approaches.
2024International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Fecal Microbiota Transplantation as an Alternative Method in the Treatment of Obesity.
2025Cureus
Relevant review or meta-analysis for the signal-disease area.
Akkermansia muciniphila: A key player in gut microbiota-based disease modulation.
2025Microbiological research
Relevant review or meta-analysis for the signal-disease area.
Design and application of synthetic human gut microbial communities.
2025Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Advances in capsule-based fecal microbiota transplantation: clinical applications and innovations.
2025Journal of translational medicine
Relevant review or meta-analysis for the signal-disease area.
Prophylactic antibiotics to prevent postcesarean infection: which antimicrobial, when, how, and why?
2026American journal of obstetrics and gynecology
Relevant review or meta-analysis for the signal-disease area.