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Candida albicans

crohn's disease

Candida albicans has meaningful literature visibility in crohn's disease, but the current evidence mix suggests a substantial risk of overclaiming.

Candida albicans shows a moderate evidence base in crohn's disease, with multiple central papers and additional supporting literature.

candida_albicans
Credibility score
63
Human translation
2/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 63Human translation 2/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
  • moderate central evidence base
  • dense review literature
  • substantial preclinical support
Main caveats
  • preclinical evidence outweighs human evidence
  • retrieval noise or disease-specificity issues may remain

Internal review flags

2 flags
preclinical_heavy

Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.

review_heavy

Review literature is very dense relative to primary central evidence.

Primary central evidence

12 papers
Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice.
2002
The American journal of pathology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Candida albicans colonization and ASCA in familial Crohn's disease.
2009
The American journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in Crohn's disease.
2014
Journal of clinical gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fungal microbiota dysbiosis in IBD.
2017
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[TITLE].
2018
Klinicheskaia laboratornaia diagnostika
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inter-kingdom relationships in Crohn's disease explored using a multi-omics approach.
2021
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immune regulation by fungal strain diversity in inflammatory bowel disease.
2022
Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immune activation of characteristic gut mycobiota Kazachstania pintolopesii on IL-23/IL-17R signaling in ankylosing spondylitis.
2022
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the Fungal Microbiome in Ulcerative Colitis.
2023
Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.
2024
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adverse Events and Immune Response in Psoriasis Patients Receiving Interleukin-17 Inhibitors.
2025
Acta dermato-venereologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Mycobiota in Patients with Inflammatory Bowel Diseases and Extraintestinal Manifestations.
2024
Gut microbes reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Behçet's disease heterogeneity: cytokine production and oxidative burst of phagocytes are altered in patients with severe manifestations.
2015
Clinical and experimental rheumatology
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

18 papers
Superoxide production by Crohn's disease neutrophils.
1991
Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Yeasts: neglected pathogens.
2009
Digestive diseases (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice.
2016
The ISME journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
2015
The New England journal of medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization.
2019
Journal of visualized experiments : JoVE
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis.
2021
Medical mycology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral non-specific lesions in patient with Crohn's disease - a case report.
2020
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Disease-relevant preclinical or model-based paper useful as supporting evidence.
H89 Treatment Reduces Intestinal Inflammation and Candida albicans Overgrowth in Mice.
2020
Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii Attenuates DSS-Induced Colitis by Inhibiting the Colonization and Pathogenicity of Candida albicans.
2021
Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Crohn's Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset.
2022
Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation.
2023
Cell reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Candida tropicalis Affects Candida albicans Virulence by Limiting Its Capacity to Adhere to the Host Intestinal Surface, Leading to Decreased Susceptibility to Colitis in Mice.
2024
Journal of fungi (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Candida tropicalis-derived vitamin B3 exerts protective effects against intestinal inflammation by promoting IL-17A/IL-22-dependent epithelial barrier function.
2024
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Global research trends and hotspots on human intestinal fungi and health: a bibliometric visualization study.
2024
Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Long-term safety and efficacy of bimekizumab in axial spondyloarthritis: 2-year results from two phase 3 studies.
2025
Rheumatology (Oxford, England)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression.
2025
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Synergistic exacerbation of oral mucositis caused by IL-23 deficiency and oral Candida albicans exposure.
2025
mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fungal virulence factors datasets for inflammatory bowel disease-specific antifungal drug discovery.
2025
Scientific data
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

32 papers
IBD serological panels: facts and perspectives.
2007
Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
Pathogenic agents in inflammatory bowel diseases.
2008
Current opinion in gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Inflammation and gastrointestinal Candida colonization.
2011
Current opinion in microbiology
Relevant review or meta-analysis for the signal-disease area.
An immunological link between Candida albicans colonization and Crohn's disease.
2015
Critical reviews in microbiology
Relevant review or meta-analysis for the signal-disease area.
Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.
2016
BMC health services research
Relevant review or meta-analysis for the signal-disease area.
Fungi in Gastrointestinal Tracts of Human and Mice: from Community to Functions.
2018
Microbial ecology
Relevant review or meta-analysis for the signal-disease area.
Clinical Trial and Registry Data.
2018
Current problems in dermatology
Relevant review or meta-analysis for the signal-disease area.
Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention.
2017
Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease.
2018
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
[Microbiota and inflammatory bowel disease: an update.].
2018
Recenti progressi in medicina
Relevant review or meta-analysis for the signal-disease area.
Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review.
2019
Clinics in dermatology
Relevant review or meta-analysis for the signal-disease area.
Review article: fungal alterations in inflammatory bowel diseases.
2019
Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Crossing Kingdoms: How the Mycobiota and Fungal-Bacterial Interactions Impact Host Health and Disease.
2021
Infection and immunity
Relevant review or meta-analysis for the signal-disease area.
Fungi of the human gut microbiota: Roles and significance.
2021
International journal of medical microbiology : IJMM
Relevant review or meta-analysis for the signal-disease area.
Food Habit Associated Mycobiota Composition and Their Impact on Human Health.
2021
Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Fungal Colonization and Infections-Interactions with Other Human Diseases.
2022
Pathogens (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Fungal microbiome in inflammatory bowel disease: a critical assessment.
2022
The Journal of clinical investigation
Relevant review or meta-analysis for the signal-disease area.
How Gut Bacterial Dysbiosis Can Promote Candida albicans Overgrowth during Colonic Inflammation.
2022
Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Immunosurveillance of Candida albicans commensalism by the adaptive immune system.
2022
Mucosal immunology
Relevant review or meta-analysis for the signal-disease area.
Manipulation of Gut Microbiota as a Key Target for Crohn's Disease.
2022
Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
Alteration of the Gut Microbiome in Inflammatory Bowel Disease.
2023
Digestion
Relevant review or meta-analysis for the signal-disease area.
Friendly fungi: symbiosis with commensal Candida albicans.
2022
Trends in immunology
Relevant review or meta-analysis for the signal-disease area.
Malassezia: A Commensal, Pathogen, and Mutualist of Human and Animal Skin.
2022
Annual review of microbiology
Relevant review or meta-analysis for the signal-disease area.
Fungal feelings in the irritable bowel syndrome: the intestinal mycobiome and abdominal pain.
2023
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Immunoglobulins at the interface of the gut mycobiota and anti-fungal immunity.
2023
Seminars in immunology
Relevant review or meta-analysis for the signal-disease area.
From ASCA breakthrough in Crohn's disease and Candida albicans research to thirty years of investigations about their meaning in human health.
2024
Autoimmunity reviews
Relevant review or meta-analysis for the signal-disease area.
Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis.
2024
Trends in microbiology
Relevant review or meta-analysis for the signal-disease area.
Oral Anti-Inflammatory and Symbiotic Effects of Fermented Lingonberry Juice-Potential Benefits in IBD.
2024
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease.
2024
World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential.
2025
Medical oncology (Northwood, London, England)
Relevant review or meta-analysis for the signal-disease area.
Fucoidan as a therapeutic agent for ulcerative colitis: mechanisms of action and modulation of the gut microbiota.
2025
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Mycobiome in Inflammatory Bowel Disease: A Systematic Review of Case-Control Studies.
2025
Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.