preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Candida albicans
atopic dermatitis
Candida albicans has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Candida albicans shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
candida_albicans
Credibility score
62
Human translation
1/5
Reproducibility
5/5
Novelty
3/5
Actionability
2/5
Credibility 62Human translation 1/5Reproducibility 5/5Novelty 3/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
9 papersFungal flora of human faeces in psoriasis and atopic dermatitis.
1990Mycoses
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Infantile seborrheic dermatitis and related syndromes. Diagnostic and pathogenetic problems].
1987La Pediatria medica e chirurgica : Medical and surgical pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Common Allergens Prevalent in and Around Ambala, Haryana: An Intradermal Study among Patients with Asthma and Allergic Rhinitis and Atopic Dermatitis.
2018Indian journal of dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of an Emollient on the Mycobiome of Atopic Dermatitis Patients.
2018Journal of drugs in dermatology : JDD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients.
2020Clinical and translational allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Candida albicans Enhances Protease Activity and Activates MyD88-Dependent IL-1β Production in Human Keratinocytes.
2025Mycoses
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Allergen Sensitization in Atopic Dermatitis: Distinction from Controls and Prediction of Respiratory Allergies.
2026International archives of allergy and immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Occurrence and clinical features of sensitization to Pityrosporum orbiculare and other allergens in children with atopic dermatitis.
1995Acta dermato-venereologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
7 papersSystemic ketoconazole for yeast allergic patients with atopic dermatitis.
2001Journal of the European Academy of Dermatology and Venereology : JEADV
Human primary paper with plausible association relevance to the disease context.
[Analysis of IgE reactivities of purified allergens from Candida albicans and Malassezia furfur among patients with atopic dermatitis].
2002Arerugi = [Allergy]
Human primary paper with plausible association relevance to the disease context.
The role of microorganisms in diaper dermatitis.
1978Archives of dermatology
Human primary paper with plausible association relevance to the disease context.
Evaluation of Candida Colonization and Specific Humoral Responses against Candida albicans in Patients with Atopic Dermatitis.
2015BioMed research international
Human primary paper with plausible association relevance to the disease context.
Napkin (diaper) dermatitis and gastrointestinal carriage of Candida albicans.
1981The British journal of dermatology
Human primary paper with plausible association relevance to the disease context.
Ketoconazole in atopic dermatitis: therapeutic response is correlated with decrease in serum IgE.
1995Archives of dermatological research
Human primary paper with plausible association relevance to the disease context.
IgE antibodies to protein and mannan antigens of pityrosporum ovale in atopic dermatitis patients.
1997Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
37 papersCandida albicans mannan- and protein-induced humoral, cellular and cytokine responses in atopic dermatitis patients.
1999Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
An assessment of the role of Candida albicans antigen in atopic dermatitis.
1999The Journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Candida in dermatology].
1999Mycoses
Disease-relevant preclinical or model-based paper useful as supporting evidence.
IFN-gamma plays a dominant role in upregulation of Candida-specific IgE synthesis in patients with atopic dermatitis.
2000International archives of allergy and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pityrosporum and Candida specific and non-specific humoral, cellular and cytokine responses in atopic dermatitis patients.
2001Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Malassezia and Candida infections in bull terriers with lethal acrodermatitis.
2001The Journal of small animal practice
Disease-relevant preclinical or model-based paper useful as supporting evidence.
IgG and IgE immune response against the surface glycoprotein gp200 of Saccharomyces cerevisiae in patients with atopic dermatitis.
2001Mycopathologia
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Malassezia and atopic dermatitis].
2003Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Frequency and clinical role of Staphylococcus aureus overinfection in atopic dermatitis in children.
2003Pediatric dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Treatment of head and neck dermatitis comparing itraconazole 200 mg and 400 mg daily for 1 week with placebo.
2004Journal of the European Academy of Dermatology and Venereology : JEADV
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cutaneous hypersensitivity to Candida albicans in idiopathic vulvodynia.
2005Contact dermatitis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice.
2006Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prevalence of Candida on the tongue and intertriginous areas of psoriatic and atopic dermatitis patients.
2008Mycoses
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Endoscopic and histological features of the large intestine in patients with atopic dermatitis.
2007Journal of clinical biochemistry and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Microecological and electron microscopic study of skin microbiota in patients with atopic dermatitis].
2010Zhurnal mikrobiologii, epidemiologii i immunobiologii
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterization of the skin fungal microbiota in patients with atopic dermatitis and in healthy subjects.
2011Microbiology and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The altered landscape of the human skin microbiome in patients with primary immunodeficiencies.
2013Genome research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Assessment of the phagocytosis and intracellular killing of Candida albicans by granulocytes of patients with atopic dermatitis].
1989Przeglad dermatologiczny
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative Analysis of Cutaneous Fungi in Atopic Dermatitis Patients and Healthy Individuals.
2022Annals of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diaper area skin microflora of normal children and children with atopic dermatitis.
1987Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis of skin microbiota with increased fungal diversity is associated with severity of disease in atopic dermatitis.
2022Journal of the European Academy of Dermatology and Venereology : JEADV
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prevalence of common sensitizing aeroallergens in patients with atopic dermatitis.
2023Cytokine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis.
2023Acta dermato-venereologica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fungal allergen sensitization: Prevalence, risk factors, and geographic variation in the United States.
2023The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Decreased skin colonization with Malassezia spp. and increased skin colonization with Candida spp. in patients with severe atopic dermatitis.
2024Frontiers in medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Molecular analysis of cutaneous yeast isolates in the mycobiota of children with atopic dermatitis.
2024Medical mycology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota profile and atopic dermatitis in the first year of life.
2024Journal of medicine and life
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Skin Mycobiome of Patients With Atopic Dermatitis and Healthy Volunteers: A Case-Control Study.
2025Experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antifungal, antibacterial, and anti-inflammatory activity of glycerol dithionomonolaurate, an analog of glycerol monolaurate.
2025mSphere
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Postauricular Skin Mycobiome Profiles in Atopic Dermatitis Treated With Dupilumab or Cyclosporine A: A Descriptive Case Series.
2026The Journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Preliminary Characterization of Skin Microbiota and Mycobiota in Atopic Dermatitis by Metagenomic and Culture-Based Analyses.
2026Life (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Determination of IgE antibodies to Candida albicans mannan with nitrocellulose-RAST in patients with atopic diseases.
1994Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Candida albicans and atopic dermatitis.
1993Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Candida albicans sensitization in patients with atopic bronchial asthma and atopic dermatitis].
1997Terapevticheskii arkhiv
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High dose intravenous immunoglobulin in atopic dermatitis and hyper-IgE syndrome.
1998Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
IgE-sensitization to cellular and culture filtrates of fungal extracts in patients with atopic dermatitis.
1998Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The importance of CD54 and CD86 costimulation in T cells stimulated with Candida albicans and Dermatophagoides farinae antigens in patients with atopic dermatitis.
1998Archives of dermatological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
15 papers[Fungi and atopic dermatitis].
1999Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology
Relevant review or meta-analysis for the signal-disease area.
Atopic dermatitis and fungi.
2002Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
Framing the future of antifungals in atopic dermatitis.
2003Dermatology (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
The pH of the skin surface and its impact on the barrier function.
2006Skin pharmacology and physiology
Relevant review or meta-analysis for the signal-disease area.
Newborn skin: Part I. Common rashes.
2008American family physician
Relevant review or meta-analysis for the signal-disease area.
Dermatoses of the breast in lactation.
2013Dermatologic therapy
Relevant review or meta-analysis for the signal-disease area.
Superficial Mycoses Associated with Diaper Dermatitis.
2016Mycopathologia
Relevant review or meta-analysis for the signal-disease area.
TH9 cells in skin disorders.
2017Seminars in immunopathology
Relevant review or meta-analysis for the signal-disease area.
Oral Aspects Identified in Atopic Dermatitis Patients: A Literature Review.
2018The open dentistry journal
Relevant review or meta-analysis for the signal-disease area.
Skin changes in the obese patient.
2019Journal of the American Academy of Dermatology
Relevant review or meta-analysis for the signal-disease area.
The clinical significance of fungi in atopic dermatitis.
2020International journal of dermatology
Relevant review or meta-analysis for the signal-disease area.
Oral mycobiome identification in atopic dermatitis, leukemia, and HIV patients - a systematic review.
2020Journal of oral microbiology
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis of skin mycobiome in atopic dermatitis.
2022Mycoses
Relevant review or meta-analysis for the signal-disease area.
Malassezia: A Commensal, Pathogen, and Mutualist of Human and Animal Skin.
2022Annual review of microbiology
Relevant review or meta-analysis for the signal-disease area.
The Role of the Cutaneous Mycobiome in Atopic Dermatitis.
2022Journal of fungi (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.