review_heavy
Review literature is very dense relative to primary central evidence.
supportedtophigh inflation risk
Candida
crohn's disease
Candida has meaningful literature visibility in crohn's disease, but the current evidence mix suggests a substantial risk of overclaiming.
Candida shows a moderate evidence base in crohn's disease, with multiple central papers and additional supporting literature.
candida
Credibility score
45
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
2/5
Credibility 45Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- dense review literature
Main caveats
- review density exceeds central evidence depth
Internal review flags
1 flagsPrimary central evidence
8 papersFungal microbiota dysbiosis in IBD.
2017Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inter-kingdom relationships in Crohn's disease explored using a multi-omics approach.
2021Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immune regulation by fungal strain diversity in inflammatory bowel disease.
2022Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the Fungal Microbiome in Ulcerative Colitis.
2023Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.
2024Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-term outcome in Wiskott-Aldrich syndrome and X-linked thrombocytopenia patients: an observational -prospective multi-center study of the Italian Primary Immune Deficiency Network (IPINET).
2025EClinicalMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adverse Events and Immune Response in Psoriasis Patients Receiving Interleukin-17 Inhibitors.
2025Acta dermato-venereologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Mycobiota in Patients with Inflammatory Bowel Diseases and Extraintestinal Manifestations.
2024Gut microbes reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
7 papersSecukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
2015The New England journal of medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
CARD9 Expression Pattern, Gene Dosage, and Immunodeficiency Phenotype Revisited.
2022Journal of clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Crohn's Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset.
2022Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation.
2023Cell reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Safety of Secukinumab from 1 Million Patient-Years of Exposure: Experience from Post-Marketing Setting and Clinical Trials.
2024Dermatology and therapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Candida tropicalis-derived vitamin B3 exerts protective effects against intestinal inflammation by promoting IL-17A/IL-22-dependent epithelial barrier function.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Long-term safety and efficacy of bimekizumab in axial spondyloarthritis: 2-year results from two phase 3 studies.
2025Rheumatology (Oxford, England)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
29 papersIBD serological panels: facts and perspectives.
2007Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
Inflammation and gastrointestinal Candida colonization.
2011Current opinion in microbiology
Relevant review or meta-analysis for the signal-disease area.
An immunological link between Candida albicans colonization and Crohn's disease.
2015Critical reviews in microbiology
Relevant review or meta-analysis for the signal-disease area.
Nocardia infections among immunomodulated inflammatory bowel disease patients: A review.
2015World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.
2016BMC health services research
Relevant review or meta-analysis for the signal-disease area.
Fungi in Gastrointestinal Tracts of Human and Mice: from Community to Functions.
2018Microbial ecology
Relevant review or meta-analysis for the signal-disease area.
Clinical Trial and Registry Data.
2018Current problems in dermatology
Relevant review or meta-analysis for the signal-disease area.
Fungal infections in patients with inflammatory bowel disease: A systematic review.
2018Mycoses
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease.
2018Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review.
2019Clinics in dermatology
Relevant review or meta-analysis for the signal-disease area.
Review article: fungal alterations in inflammatory bowel diseases.
2019Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Crossing Kingdoms: How the Mycobiota and Fungal-Bacterial Interactions Impact Host Health and Disease.
2021Infection and immunity
Relevant review or meta-analysis for the signal-disease area.
Fungi of the human gut microbiota: Roles and significance.
2021International journal of medical microbiology : IJMM
Relevant review or meta-analysis for the signal-disease area.
Food Habit Associated Mycobiota Composition and Their Impact on Human Health.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Fungal Colonization and Infections-Interactions with Other Human Diseases.
2022Pathogens (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Fungal microbiome in inflammatory bowel disease: a critical assessment.
2022The Journal of clinical investigation
Relevant review or meta-analysis for the signal-disease area.
How Gut Bacterial Dysbiosis Can Promote Candida albicans Overgrowth during Colonic Inflammation.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Manipulation of Gut Microbiota as a Key Target for Crohn's Disease.
2022Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
Alteration of the Gut Microbiome in Inflammatory Bowel Disease.
2023Digestion
Relevant review or meta-analysis for the signal-disease area.
Friendly fungi: symbiosis with commensal Candida albicans.
2022Trends in immunology
Relevant review or meta-analysis for the signal-disease area.
Malassezia: A Commensal, Pathogen, and Mutualist of Human and Animal Skin.
2022Annual review of microbiology
Relevant review or meta-analysis for the signal-disease area.
Fungal feelings in the irritable bowel syndrome: the intestinal mycobiome and abdominal pain.
2023Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Immunoglobulins at the interface of the gut mycobiota and anti-fungal immunity.
2023Seminars in immunology
Relevant review or meta-analysis for the signal-disease area.
Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis.
2024Trends in microbiology
Relevant review or meta-analysis for the signal-disease area.
Oral Anti-Inflammatory and Symbiotic Effects of Fermented Lingonberry Juice-Potential Benefits in IBD.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
AGA Clinical Practice Update on Esophageal Dysfunction Due to Disordered Immunity and Infection: Expert Review.
2024Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Relevant review or meta-analysis for the signal-disease area.
Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease.
2024World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential.
2025Medical oncology (Northwood, London, England)
Relevant review or meta-analysis for the signal-disease area.
Gut Mycobiome in Inflammatory Bowel Disease: A Systematic Review of Case-Control Studies.
2025Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.