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Candida

atopic dermatitis

Candida has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.

Candida has a broader but less central evidence footprint in atopic dermatitis, with support coming from indirect, review, or preclinical literature.

candida
Credibility score
40
Human translation
1/5
Reproducibility
5/5
Novelty
3/5
Actionability
1/5
Credibility 40Human translation 1/5Reproducibility 5/5Novelty 3/5Actionability 1/5
Why this scores the way it does
  • meaningful supporting human literature
  • dense review literature
  • substantial preclinical support
Main caveats
  • preclinical evidence outweighs human evidence
  • limited central evidence

Internal review flags

1 flags
preclinical_heavy

Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.

Primary central evidence

4 papers
Fungal flora of human faeces in psoriasis and atopic dermatitis.
1990
Mycoses
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients.
2018
Allergology international : official journal of the Japanese Society of Allergology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of an Emollient on the Mycobiome of Atopic Dermatitis Patients.
2018
Journal of drugs in dermatology : JDD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Occurrence and clinical features of sensitization to Pityrosporum orbiculare and other allergens in children with atopic dermatitis.
1995
Acta dermato-venereologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

3 papers
[Role of Candida allergen in atopic dermatitis and efficacy of oral therapy with various antifungal agents].
1999
Arerugi = [Allergy]
Human primary paper with plausible association relevance to the disease context.
The role of microorganisms in diaper dermatitis.
1978
Archives of dermatology
Human primary paper with plausible association relevance to the disease context.
Evaluation of Candida Colonization and Specific Humoral Responses against Candida albicans in Patients with Atopic Dermatitis.
2015
BioMed research international
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

26 papers
Candida albicans mannan- and protein-induced humoral, cellular and cytokine responses in atopic dermatitis patients.
1999
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Candida in dermatology].
1999
Mycoses
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pityrosporum and Candida specific and non-specific humoral, cellular and cytokine responses in atopic dermatitis patients.
2001
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Malassezia and atopic dermatitis].
2003
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Frequency and clinical role of Staphylococcus aureus overinfection in atopic dermatitis in children.
2003
Pediatric dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice.
2006
Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prevalence of Candida on the tongue and intertriginous areas of psoriatic and atopic dermatitis patients.
2008
Mycoses
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Endoscopic and histological features of the large intestine in patients with atopic dermatitis.
2007
Journal of clinical biochemistry and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Microecological and electron microscopic study of skin microbiota in patients with atopic dermatitis].
2010
Zhurnal mikrobiologii, epidemiologii i immunobiologii
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterization of the skin fungal microbiota in patients with atopic dermatitis and in healthy subjects.
2011
Microbiology and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The altered landscape of the human skin microbiome in patients with primary immunodeficiencies.
2013
Genome research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative Analysis of Cutaneous Fungi in Atopic Dermatitis Patients and Healthy Individuals.
2022
Annals of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis of skin microbiota with increased fungal diversity is associated with severity of disease in atopic dermatitis.
2022
Journal of the European Academy of Dermatology and Venereology : JEADV
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prevalence of common sensitizing aeroallergens in patients with atopic dermatitis.
2023
Cytokine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis.
2023
Acta dermato-venereologica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fungal allergen sensitization: Prevalence, risk factors, and geographic variation in the United States.
2023
The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Decreased skin colonization with Malassezia spp. and increased skin colonization with Candida spp. in patients with severe atopic dermatitis.
2024
Frontiers in medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Molecular analysis of cutaneous yeast isolates in the mycobiota of children with atopic dermatitis.
2024
Medical mycology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota profile and atopic dermatitis in the first year of life.
2024
Journal of medicine and life
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Skin Mycobiome of Patients With Atopic Dermatitis and Healthy Volunteers: A Case-Control Study.
2025
Experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antifungal, antibacterial, and anti-inflammatory activity of glycerol dithionomonolaurate, an analog of glycerol monolaurate.
2025
mSphere
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Postauricular Skin Mycobiome Profiles in Atopic Dermatitis Treated With Dupilumab or Cyclosporine A: A Descriptive Case Series.
2026
The Journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Preliminary Characterization of Skin Microbiota and Mycobiota in Atopic Dermatitis by Metagenomic and Culture-Based Analyses.
2026
Life (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Candida albicans and atopic dermatitis.
1993
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High dose intravenous immunoglobulin in atopic dermatitis and hyper-IgE syndrome.
1998
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
IgE-sensitization to cellular and culture filtrates of fungal extracts in patients with atopic dermatitis.
1998
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

17 papers
[Fungi and atopic dermatitis].
1999
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology
Relevant review or meta-analysis for the signal-disease area.
Atopic dermatitis and fungi.
2002
Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
Framing the future of antifungals in atopic dermatitis.
2003
Dermatology (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
The pH of the skin surface and its impact on the barrier function.
2006
Skin pharmacology and physiology
Relevant review or meta-analysis for the signal-disease area.
Newborn skin: Part I. Common rashes.
2008
American family physician
Relevant review or meta-analysis for the signal-disease area.
Dermatoses of the breast in lactation.
2013
Dermatologic therapy
Relevant review or meta-analysis for the signal-disease area.
Efinaconazole (Jublia) for the treatment of onychomycosis.
2014
Expert review of anti-infective therapy
Relevant review or meta-analysis for the signal-disease area.
Superficial Mycoses Associated with Diaper Dermatitis.
2016
Mycopathologia
Relevant review or meta-analysis for the signal-disease area.
TH9 cells in skin disorders.
2017
Seminars in immunopathology
Relevant review or meta-analysis for the signal-disease area.
Oral Aspects Identified in Atopic Dermatitis Patients: A Literature Review.
2018
The open dentistry journal
Relevant review or meta-analysis for the signal-disease area.
The role of Langerhans cells in pathologies of the skin.
2019
Immunology and cell biology
Relevant review or meta-analysis for the signal-disease area.
Skin changes in the obese patient.
2019
Journal of the American Academy of Dermatology
Relevant review or meta-analysis for the signal-disease area.
The clinical significance of fungi in atopic dermatitis.
2020
International journal of dermatology
Relevant review or meta-analysis for the signal-disease area.
Oral mycobiome identification in atopic dermatitis, leukemia, and HIV patients - a systematic review.
2020
Journal of oral microbiology
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis of skin mycobiome in atopic dermatitis.
2022
Mycoses
Relevant review or meta-analysis for the signal-disease area.
Malassezia: A Commensal, Pathogen, and Mutualist of Human and Animal Skin.
2022
Annual review of microbiology
Relevant review or meta-analysis for the signal-disease area.
The Role of the Cutaneous Mycobiome in Atopic Dermatitis.
2022
Journal of fungi (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.