preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Butyrate production
atopic dermatitis
Butyrate production has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Butyrate production shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
butyrate_production
Credibility score
47
Human translation
1/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 47Human translation 1/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
11 papersLKM512 yogurt consumption improves the intestinal environment and induces the T-helper type 1 cytokine in adult patients with intractable atopic dermatitis.
2007Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis.
2016The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant.
2020Allergy, asthma & immunology research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interactions Between IL-17 Variants and Streptococcus in the Gut Contribute to the Development of Atopic Dermatitis in Infancy.
2021Allergy, asthma & immunology research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis.
2022Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy.
2022Allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility.
2023Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between gut microbiota development and allergy in infants born during pandemic-related social distancing restrictions.
2024Allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary Galacto-oligosaccharides Ameliorate Atopic Dermatitis-like Skin Inflammation and Behavioral Deficits by Modulating Gut Microbiota-Brain-Skin Axis.
2024Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
High-fat diet exacerbates atopic dermatitis through alterations in the gut microbiome.
2026The Journal of nutritional biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
31 papersEfficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis.
2002The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical corticosteroids and Staphylococcus aureus in atopic dermatitis.
1992Journal of the American Academy of Dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial.
2006The British journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hydrocortisone butyrate 0.1% lipocream in pediatric patients with atopic dermatitis.
2010Skinmed
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hydrocortisone butyrate 0.1% cream (proprietary lipid rich cream vehicle) does not significantly suppress hypothalamic-pituitary-adrenal axis and is effective in pediatric patients 3 months and older with extensive atopic dermatitis.
2010Skinmed
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical clofibrate improves symptoms in patients with atopic dermatitis and reduces serum TARC levels: a randomized, double-blind, placebo-controlled pilot study.
2014Journal of drugs in dermatology : JDD
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate-producing bacteria.
2015Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study.
2016The British journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-Inflammatory Effects of a Mixture of Lactic Acid Bacteria and Sodium Butyrate in Atopic Dermatitis Murine Model.
2018Journal of medicinal food
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cream Cheese-Derived Lactococcus chungangensis CAU 28 Modulates the Gut Microbiota and Alleviates Atopic Dermatitis in BALB/c Mice.
2019Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral Administration of β-Glucan and Lactobacillus plantarum Alleviates Atopic Dermatitis-Like Symptoms.
2019Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis.
2019Frontiers in molecular biosciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice.
2020European journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ruminococcus gnavus ameliorates atopic dermatitis by enhancing Treg cell and metabolites in BALB/c mice.
2022Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effective treatment of atopic dermatitis in small children significantly improves the quality of life of patients and their families.
2021European journal of dermatology : EJD
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation.
2022Mucosal immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Evaluation of standard treatments for managing adult Japanese patients with inadequately controlled moderate-to-severe atopic dermatitis: Two-year data from the ADDRESS-J disease registry.
2022The Journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial.
2022Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Olive-Derived Antioxidant Dietary Fiber Modulates Gut Microbiota Composition and Attenuates Atopic Dermatitis Like Inflammation in Mice.
2023Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fructo-oligofructose ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions and psychiatric comorbidities in mice.
2023Journal of the science of food and agriculture
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway.
2024Inflammation
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alterations in gut microbiome associated with severity of atopic dermatitis in infants.
2024The Australasian journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Short-term effect of a moderate-potency topical corticosteroid on epidermal biophysical parameters in patients with mild-to-moderate atopic dermatitis: A randomised controlled study.
2024Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Chickpea-resistant starch exhibits bioactive function for alleviating atopic dermatitis via regulating butyrate production.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Beneficial Effects of a N-(1-Carbamoyl-2-phenyl-ethyl) Butyramide on Human Keratinocytes.
2025Pharmaceuticals (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Partially hydrolyzed guar gum ingestion suppresses atopic dermatitis-like symptoms through prebiotic effect in mice.
2025Journal of clinical biochemistry and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Case of Idiopathic Follicular Mucinosis Treated Successfully with Cyclosporine.
2024Acta dermatovenerologica Croatica : ADC
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hyaluronic acid-butyrate conjugates for barrier restoration in atopic dermatitis: CD44-mediated retention and inflammation-responsive release.
2026Carbohydrate polymers
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Butyrylated Smilax glabra starch relieves atopic dermatitis through gut-skin axis modulation via colon-targeted delivery.
2025Acta pharmaceutica Sinica. B
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Schleiferilactobacillus harbinensis JNDM Postbiotics Alleviate Atopic Dermatitis with Concurrent Changes in Gut Microbiota and Fecal SCFAs.
2026Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Efficacy and safety of hydrocortisone buteprate 0.1% cream in patients with atopic dermatitis.
1997Clinical therapeutics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
8 papersEfficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials.
2005BMJ (Clinical research ed.)
Relevant review or meta-analysis for the signal-disease area.
Tacrolimus ointment: a review of its use in atopic dermatitis and its clinical potential in other inflammatory skin conditions.
2005Drugs
Relevant review or meta-analysis for the signal-disease area.
Comparison of the efficacy and safety of 0.1% tacrolimus ointment with topical corticosteroids in adult patients with atopic dermatitis: review of randomised, double-blind clinical studies conducted in Japan.
2006Clinical drug investigation
Relevant review or meta-analysis for the signal-disease area.
Lower caprylate and acetate levels in the breast milk is associated with atopic dermatitis in infancy.
2022Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Relevant review or meta-analysis for the signal-disease area.
Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases.
2022Molecules (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
A major mechanism for immunomodulation: Dietary fibres and acid metabolites.
2023Seminars in immunology
Relevant review or meta-analysis for the signal-disease area.
Systematic review of the association between short-chain fatty acids and allergic diseases.
2024Allergy
Relevant review or meta-analysis for the signal-disease area.
Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease.
2025Microorganisms
Relevant review or meta-analysis for the signal-disease area.