sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Blautia
type 2 diabetes
Blautia looks like a credible signal in type 2 diabetes, though some caution is still warranted.
Blautia shows a strong literature footprint in type 2 diabetes, with substantial central evidence and broader supporting literature.
blautia
Credibility score
68
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 68Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
22 papersRelationship between gut microbiota and type 2 diabetic erectile dysfunction in Sprague-Dawley rats.
2017Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical Trial.
2018mBio
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia.
2020Medicine and science in sports and exercise
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota, and Incident Type 2 Diabetes: A Prospective Cohort Study.
2020Diabetes care
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes.
2020The Journal of international medical research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis and Implication of the Gut Microbiota in Diabetic Retinopathy.
2021Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation Between Gut Microbiota and Testosterone in Male Patients With Type 2 Diabetes Mellitus.
2022Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition and diversity of gut microbiota in diabetic retinopathy.
2022Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distribution characteristics of oral microbiota and its relationship with intestinal microbiota in patients with type 2 diabetes mellitus.
2023Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Composition, Their Interactions, and Metagenome Function in US Adults with Type 2 Diabetes According to Enterotypes.
2023International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The effect of metformin combined with liraglutide on gut microbiota of Chinese patients with type 2 diabetes.
2024International microbiology : the official journal of the Spanish Society for Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis signatures of gut microbiota and the progression of type 2 diabetes: a machine learning approach in a Mexican cohort.
2023Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome profile of Chinese hypertension patients with and without type 2 diabetes mellitus.
2023BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multiomics Analyses With Stool-Type Stratification in Patient Cohorts and Blautia Identification as a Potential Bacterial Modulator in Type 2 Diabetes Mellitus.
2024Diabetes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Functional alterations and predictive capacity of gut microbiome in type 2 diabetes.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of short-chain fatty acids and the gut microbiome with type 2 diabetes: Evidence from the Henan Rural Cohort.
2024Nutrition, metabolism, and cardiovascular diseases : NMCD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of Gut Microbiota in Pyogenic Liver Abscess Patients with and without Type 2 Diabetes Mellitus.
2024Infection and drug resistance
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dried chicory root improves bowel function, benefits intestinal microbial trophic chains and increases faecal and circulating short chain fatty acids in subjects at risk for type 2 diabetes.
2022Gut microbiome (Cambridge, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut-kidney axis.
2024Frontiers in pharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population.
2025Journal of diabetes investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiome analysis in patients with metabolic syndrome and type 2 diabetes.
2025PeerJ
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrative analysis of gut microbiota and metabolic pathways reveals key microbial and metabolomic alterations in diabetes.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
20 papersAlteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men.
2019Journal of diabetes investigation
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice.
2019Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterisation of gut microbiota of obesity and type 2 diabetes in a rodent model.
2021Bioscience of microbiota, food and health
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota of patients with type 2 diabetes and gastrointestinal intolerance to metformin differs in composition and functionality from tolerant patients.
2022Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pi-Dan-Jian-Qing Decoction Ameliorates Type 2 Diabetes Mellitus Through Regulating the Gut Microbiota and Serum Metabolism.
2021Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shenqi compound ameliorates type-2 diabetes mellitus by modulating the gut microbiota and metabolites.
2022Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Interrelations between Gut Microbiota Composition, Nutrient Intake and Diabetes Status in an Adult Japanese Population.
2022Journal of clinical medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.
2022Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice.
2022Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Baihu renshen decoction ameliorates type 2 diabetes mellitus in rats through affecting gut microbiota enhancing gut permeability and inhibiting TLR4/NF-κB-mediated inflammatory response.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bear bile powder ameliorates type 2 diabetes via modulation of metabolic profiles, gut microbiota, and metabolites.
2022Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota-host co-metabolism of branched-chain amino acid.
2023Phytotherapy research : PTR
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Camel milk peptides alleviate hyperglycemia by regulating gut microbiota and metabolites in type 2 diabetic mice.
2023Food research international (Ottawa, Ont.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characteristics of intestinal flora in patients with cerebral infarction complicated with Type 2 diabetes mellitus.
2023Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Phage cocktail alleviated type 2 diabetes by reshaping gut microbiota and decreasing proinflammatory cytokines.
2024Applied microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis.
2024Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiome-metabolome dynamics associated with impaired glucose control and responses to lifestyle changes.
2025Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characteristic dysbiosis in patients with type 2 diabetes and hyperuricemia, and the effect of empagliflozin on gut microbiota.
2025World journal of diabetes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bile-processed Rhizoma Coptidis alleviates type 2 diabetes mellitus through modulating the gut microbiota and short-chain fatty acid metabolism.
2025International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bioengineered ROS-tolerant probiotic reshapes gut microbiota-host axis to ameliorate type 2 diabetes in male mice.
2026Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
6 papersModulation of the gut microbiome: a systematic review of the effect of bariatric surgery.
2018European journal of endocrinology
Relevant review or meta-analysis for the signal-disease area.
Role of gut microbiota in type 2 diabetes pathophysiology.
2020EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Characteristics of the gut microbiome in women with gestational diabetes mellitus: A systematic review.
2022PloS one
Relevant review or meta-analysis for the signal-disease area.
Pharmacomicrobiomics in Western Medicine and Traditional Chinese Medicine in Type 2 Diabetes.
2022Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
Relationship between changes in microbiota induced by resveratrol and its anti-diabetic effect on type 2 diabetes.
2022Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
The Microbial Regulation Spectrum of Metformin in Patients With Type 2 Diabetes: An Individual-Based Meta-Analysis of 1431 Participants.
2025The Journal of clinical endocrinology and metabolism
Relevant review or meta-analysis for the signal-disease area.