sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Blautia
obesity
Blautia looks like a credible signal in obesity, though some caution is still warranted.
Blautia shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
blautia
Credibility score
75
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 75Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
24 papersIntestinal Proportion of Blautia sp. is Associated with Clinical Stage and Histoprognostic Grade in Patients with Early-Stage Breast Cancer.
2017Nutrition and cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia.
2020Medicine and science in sports and exercise
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children.
2020Experimental & molecular medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota of Chinese Obese Children and Adolescents With and Without Insulin Resistance.
2021Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in Compositions of Oral and Fecal Microbiota between Patients with Obesity and Controls.
2021Medicina (Kaunas, Lithuania)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota in people with obesity.
2021PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Maternal pre-pregnancy overweight and neonatal gut bacterial colonization are associated with cognitive development and gut microbiota composition in pre-school-age offspring.
2022Brain, behavior, and immunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Associations of Blautia Genus With Early-Life Events and Later Phenotype in the NutriHS.
2022Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between the Blautia/Bacteroides Ratio and Altered Body Mass Index after Bariatric Surgery.
2022Endocrinology and metabolism (Seoul, Korea)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
d-Arabitol Ameliorates Obesity and Metabolic Disorders via the Gut Microbiota-SCFAs-WAT Browning Axis.
2023Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Vitamin B12 Status and Gut Microbiota among Saudi Females with Obesity.
2022Foods (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in nonalcoholic fatty liver disease: a PREDIMED-Plus trial sub analysis.
2023Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility.
2024Medical microbiology and immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.
2024International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary Antrodia cinnamomea Polysaccharide Intervention Modulates Clinical Symptoms by Regulating Ovarian Metabolites and Restructuring the Intestinal Microbiota in Rats with Letrozole-Induced PCOS.
2024Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ramulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism.
2024Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity.
2024Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Aerobic Exercise and Intermittent Fasting on Fecal Microbiome Diversity in Obese Mice.
2025Discovery medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of gut microbiota with overweight/obesity combined with gestational diabetes mellitus.
2025Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of beinaglutide on visceral fat area and gut microbiota in obesity.
2025European journal of medical research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Effect of Probiotics on the Improvement of Body Weight and Fat.
2025Food science & nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
18 papersResveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice.
2020International journal of obesity (2005)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening.
2020mSystems
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Allicin-induced host-gut microbe interactions improves energy homeostasis.
2020FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.
2022Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The berberine-enriched gut commensal Blautia producta ameliorates high-fat diet (HFD)-induced hyperlipidemia and stimulates liver LDLR expression.
2022Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Novel Symbiotic Formulation Reduces Obesity and Concomitant Metabolic Syndrome in Rats by Raising the Relative Abundance of Blautia.
2023Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Distinct Lipids Profiles and Associations With Clinical Indicators and Gut Microbiota in Children With Prader-Willi Syndrome.
2023Endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mouse Model of Anti-Obesity Effects of Blautia hansenii on Diet-Induced Obesity.
2023Current issues in molecular biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ethanologenesis from glycerol by the gut acetogen Blautia schinkii.
2023Environmental microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.
2024Biological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota signatures of vulnerability to food addiction in mice and humans.
2024Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis.
2024Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Different Short-Chain Fatty Acids Unequally Modulate Intestinal Homeostasis and Reverse Obesity-Related Symptoms in Lead-Exposed High-Fat Diet Mice.
2024Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Betaine and Polydextrose on Intestinal Microbiota and Liver Ergothioneine in a High-Fat Diet-Fed Mouse Model and a Human Colonic Simulation Model.
2024Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multi-omics analyses the effect of Bifidobacterium longum subsp. longum BL21 supplementation on overweight and obese subjects: a randomized, double-blind, placebo-controlled study.
2025Nutrition & metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Genistein supplementation alleviates bone damage by regulating gut microbiota composition and metabolism in obesity and estrogen decline.
2025Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Berberine combined with stachyose protects against obesity by modulating gut microbiota and increasing leptin sensitivity.
2026Science China. Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
10 papersModulation of the gut microbiome: a systematic review of the effect of bariatric surgery.
2018European journal of endocrinology
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
Pharmacomicrobiomics in Western Medicine and Traditional Chinese Medicine in Type 2 Diabetes.
2022Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
The interplay between herbal medicines and gut microbiota in metabolic diseases.
2023Frontiers in pharmacology
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review.
2024International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
The Ambiguous Correlation of Blautia with Obesity: A Systematic Review.
2024Microorganisms
Relevant review or meta-analysis for the signal-disease area.
How important are fatty acids in human health and can they be used in treating diseases?
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Association between gut microbiota and pediatric obesity: A systematic review.
2025Nutrition (Burbank, Los Angeles County, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review.
2025Endocrinologia, diabetes y nutricion
Relevant review or meta-analysis for the signal-disease area.