sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Blautia
inflammatory bowel disease
Blautia looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Blautia shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
blautia
Credibility score
67
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 67Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
23 papersSpecificities of the intestinal microbiota in patients with inflammatory bowel disease and Clostridium difficile infection.
2018Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Correlation between Vitamin D Status and Gut Microbiota in Patients with Inflammatory Bowel Disease].
2020Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clinical response and changes in the fecal microbiota and metabolite levels after fecal microbiota transplantation in patients with inflammatory bowel disease and recurrent Clostridioides difficile infection.
2021Fujita medical journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Typing of the Gut Microbiota Community in Japanese Subjects.
2022Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Location-specific signatures of Crohn's disease at a multi-omics scale.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Risk factors and characteristics of gut microbiota and metabolites in inflammatory bowel diseases patients with urolithiasis].
2022Zhonghua yi xue za zhi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Development of the intestinal microbiome in cystic fibrosis in early life.
2023mSphere
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Early-life gut microbiota in food allergic children and its impact on the development of allergic disease.
2023Italian journal of pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reverse-engineered exclusive enteral nutrition in pediatric Crohn's disease: A pilot trial.
2024Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota is associated with extraintestinal manifestations in inflammatory bowel disease.
2024Annals of medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inflammatory bowel disease associated with primary sclerosing cholangitis is associated with an altered gut microbiome and bile acid profile.
2024Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Shotgun Analysis of Gut Microbiota with Body Composition and Lipid Characteristics in Crohn's Disease.
2024Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal deoxycholic acid associates with diet, intestinal microbes, and total bilirubin in primary sclerosing cholangitis.
2024JHEP reports : innovation in hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Open Label Vancomycin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Improved Colonic Disease Activity and Associations With Changes in Host-Microbiome-Metabolomic Signatures.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
HiBC: a publicly available collection of bacterial strains isolated from the human gut.
2025Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome signatures predict 5-ASA efficacy in ulcerative colitis.
2025iScience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[1]The human gut microbiota in IBD, characterizing hubs, the core microbiota and terminal nodes: a network-based approach.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbial and metabolic signatures in children with very early onset inflammatory bowel disease.
2025NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
18 papersThe features of mucosa-associated microbiota in primary sclerosing cholangitis.
2016Alimentary pharmacology & therapeutics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Impact of Cyanocobalamin and Methylcobalamin on Inflammatory Bowel Disease and the Intestinal Microbiota Composition.
2019Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Exopolysaccharides from Lactobacillus plantarum YW11 improve immune response and ameliorate inflammatory bowel disease symptoms.
2020Acta biochimica Polonica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Periodontitis Salivary Microbiota Worsens Colitis.
2022Journal of dental research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prenatal Maternal Stress Exacerbates Experimental Colitis of Offspring in Adulthood.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota.
2023Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.
2023Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Insulin alleviates murine colitis through microbiome alterations and bile acid metabolism.
2023Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Commensal bacteria promote azathioprine therapy failure in inflammatory bowel disease via decreasing 6-mercaptopurine bioavailability.
2023Cell reports. Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Regulation of gut microbiota and alleviation of DSS-induced colitis by vitexin.
2023European journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The intestinal microbiome, but not clinical aspects of inflammatory bowel disease, is impacted by lactose malabsorption compared to lactose digestion in children.
2024The American journal of clinical nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Unlocking the power of swine gut bacteria: newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS-induced colitis in mice.
2025Journal of animal science and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiome-metabolome generated bile acids gatekeep infliximab efficacy in Crohn's disease by licensing M1 suppression and Treg dominance.
2026Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The mitigative effects of Blautia producta 1009924 on DSS-induced intestinal inflammation.
2025Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair.
2025Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program.
2026Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
3 papersGut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review.
2021Frontiers in pediatrics
Relevant review or meta-analysis for the signal-disease area.
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.
2021Gut
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.