Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer.
2012PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Blautia
colorectal cancer
Blautia appears to be a strong and relatively human-grounded signal in colorectal cancer.
Blautia shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.
blautia
Credibility score
83
Human translation
5/5
Reproducibility
5/5
Novelty
2/5
Actionability
4/5
Credibility 83Human translation 5/5Reproducibility 5/5Novelty 2/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
Main caveats
- directionality and confounding still require curated review
Primary central evidence
31 papersDifferences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans.
2019Nutrition and cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation.
2019BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The influence of blood on the human gut microbiome.
2020BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Comparison of Fecal Microbiota in Left-Side and Right-Side Human Colorectal Cancer.
2021European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality.
2021Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the fecal microbiota in gastrointestinal cancer patients and healthy people.
2022Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota correlates with antitumor activity in patients with mCRC and NSCLC treated with cetuximab plus avelumab.
2022International journal of cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and Fecal Metabolome in Colorectal Cancer: Implication of Intestinal Metabolism for Tumorigenesis.
2022Frontiers in physiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Different Characteristics in Gut Microbiome between Advanced Adenoma Patients and Colorectal Cancer Patients by Metagenomic Analysis.
2022Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prediction model of poorly differentiated colorectal cancer (CRC) based on gut bacteria.
2022BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Postoperative Probiotics Administration Attenuates Gastrointestinal Complications and Gut Microbiota Dysbiosis Caused by Chemotherapy in Colorectal Cancer Patients.
2023Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance.
2023Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut bacteria and sex differences in colorectal cancer.
2023Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Analysis of Intratumoral Microbiome Linking to Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer.
2023International journal of radiation oncology, biology, physics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota and Associated Volatile Organic Compounds Distinguishing No-Adenoma from High-Risk Colon Adenoma Adults.
2023Metabolites
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Veillonella Bacteremia in a Patient With Metastatic Colorectal Carcinoma.
2023Cureus
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of gut microbiota during fecal stream diversion in patients with colorectal cancer.
2023Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Optimizing Fecal Occult Blood Test (FOBT) Colorectal Cancer Screening Using Gut Bacteriome as a Biomarker.
2024Clinical colorectal cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Possible Preventative Role of Lactate- and Butyrate-Producing Bacteria in Colorectal Carcinogenesis.
2024Gut and liver
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The multispecies microbial cluster of Fusobacterium, Parvimonas, Bacteroides and Faecalibacterium as a precision biomarker for colorectal cancer diagnosis.
2024Molecular oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of enterotype and its predictive value for patients with colorectal cancer.
2024Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Third-generation PacBio sequencing to explore gut bacteria and gender in colorectal cancer.
2024Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Detection and comparison of tumor cell-associated microbiota from different compartments of colorectal cancer.
2024Frontiers in oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Emergence of rare and low abundant anaerobic gut Firmicutes is associated with a significant downfall of Klebsiella in human colon cancer.
2024Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer.
2024Med (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial subtypes and clinicopathological value for colorectal cancer.
2024Cancer medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut commensal Alistipes as a potential pathogenic factor in colorectal cancer.
2024Discover oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Cell free supernatants of Bifidobacterium adolescentis and Bifidobacterium longum suppress the tumor growth in colorectal cancer organoid model.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Mucosal Microbiome of Patients With Low-Grade Adenomatous Bowel Polyps.
2025Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersMendelian randomization study of causal link from gut microbiota to colorectal cancer.
2022BMC cancer
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
9 papersIntegration of the Microbiome, Metabolome and Transcriptomics Data Identified Novel Metabolic Pathway Regulation in Colorectal Cancer.
2021International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Xiao-Chai-Hu-Tang ameliorates tumor growth in cancer comorbid depressive symptoms via modulating gut microbiota-mediated TLR4/MyD88/NF-κB signaling pathway.
2021Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of Gut Microbiota Combined with Upregulation of Intestinal Tight Junction Explains Anti-Inflammatory Effect of Corylin on Colitis-Associated Cancer in Mice.
2022International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gender-based effect of absence of gut microbiota on the protective efficacy of Bifidobacterium longum-fermented rice bran diet against inflammation-associated colon tumorigenesis.
2022Molecular carcinogenesis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered gut microbiome composition by appendectomy contributes to colorectal cancer.
2023Oncogene
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut colonization of Bacteroides plebeius suppresses colitis-associated colon cancer development.
2025Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersGut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review.
2025Metabolites
Relevant review or meta-analysis for the signal-disease area.