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Blautia

autism

Blautia is an interesting but still moderate-confidence signal in autism.

Blautia shows a strong literature footprint in autism, with substantial central evidence and broader supporting literature.

blautia
Credibility score
53
Human translation
4/5
Reproducibility
4/5
Novelty
3/5
Actionability
4/5
Credibility 53Human translation 4/5Reproducibility 4/5Novelty 3/5Actionability 4/5
Why this scores the way it does
  • strong central evidence base
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

17 papers
A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders.
2016
Bioscience, biotechnology, and biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Treatment with the traditional Chinese medicine BuYang HuanWu Tang induces alterations that normalize the microbiome in ASD patients.
2020
Bioscience of microbiota, food and health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of gut microbiota between adults with autism spectrum disorder and obese adults.
2021
PeerJ
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China: A case-control study.
2021
Synthetic and systems biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of probiotics combined with applied behavior analysis in the treatment of children with autism spectrum disorder: a prospective randomized controlled trial.
2021
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alteration of the fecal microbiota in Chinese children with autism spectrum disorder.
2022
Autism research : official journal of the International Society for Autism Research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases.
2023
Journal of Alzheimer's disease : JAD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alteration of the gut microbiota profile in children with autism spectrum disorder in China.
2023
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects and microbiota changes following oral lyophilized fecal microbiota transplantation in children with autism spectrum disorder.
2024
Frontiers in pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comprehensive Analysis of Gut Microbiota Composition and Functional Metabolism in Children with Autism Spectrum Disorder and Neurotypical Children: Implications for Sex-Based Differences and Metabolic Dysregulation.
2024
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correction of Batch Effect in Gut Microbiota Profiling of ASD Cohorts from Different Geographical Origins.
2024
Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Stratification of Gut Microbiota Profiling Based on Autism Neuropsychological Assessments.
2024
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and urine metabolomics signature in autism spectrum disorder children from Southern China.
2025
BMC pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered gut microbiota composition and feeding behaviours in children with Autism Spectrum Disorder: a comparative pilot study.
2025
Annals of human biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Characterization of Gut Microbiota in Children with Autism Spectrum Disorder: Microbial Signatures and Modulation by Anti-Inflammatory Diet and Probiotics.
2025
Pharmaceuticals (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying gut microbiota composition disparities in autistic individuals and their unaffected siblings: correlations with clinical characteristics.
2025
Translational psychiatry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Characterization of Intestinal Microbiota and Probiotics Treatment in Children With Autism Spectrum Disorders in China.
2019
Frontiers in neurology
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

8 papers
Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder.
2017
Cellular and molecular gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism.
2017
EBioMedicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism.
2022
Brain, behavior, and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice.
2023
Experimental neurology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis.
2023
The Science of the total environment
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members.
2024
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeted fecal microbiota transplantation ameliorates autism-like behaviors via gut-brain axis and excitatory/inhibitory balance restoration in a propionic acid mouse model.
2026
Brain, behavior, and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome alterations are sex-dependently associated with brain abnormalities in a mouse model of Neurofibromatosis type I.
2026
Molecular psychiatry
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

7 papers
Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review.
2019
Translational psychiatry
Relevant review or meta-analysis for the signal-disease area.
Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.
2022
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Exercise Changes Gut Microbiota: A New Idea to Explain that Exercise Improves Autism.
2023
International journal of sports medicine
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
2023
Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Genus-Level Analysis of Gut Microbiota in Children with Autism Spectrum Disorder: A Mini Review.
2023
Children (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Revealing the gut microbiome mystery: A meta-analysis revealing differences between individuals with autism spectrum disorder and neurotypical children.
2024
Bioscience trends
Relevant review or meta-analysis for the signal-disease area.
The relationship between the gut microbiota and neuropsychological development and behaviour during childhood and adolescence: a systematic review of epidemiological studies.
2026
Brain, behavior, & immunity - health
Relevant review or meta-analysis for the signal-disease area.