preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Bilophila wadsworthia
ulcerative colitis
Bilophila wadsworthia has meaningful literature visibility in ulcerative colitis, but the current evidence mix suggests a substantial risk of overclaiming.
Bilophila wadsworthia shows a moderate evidence base in ulcerative colitis, with multiple central papers and additional supporting literature.
bilophila_wadsworthia
Credibility score
20
Human translation
2/5
Reproducibility
2/5
Novelty
4/5
Actionability
2/5
Credibility 20Human translation 2/5Reproducibility 2/5Novelty 4/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
6 papersDiversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease.
2012FEMS immunology and medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut dysbiosis and clinical phases of pancolitis in patients with ulcerative colitis.
2021MicrobiologyOpen
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients.
2023EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial signatures and their functions in Behcet's uveitis and Vogt-Koyanagi-Harada disease.
2023Journal of autoimmunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue.
2026World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
9 papersComparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.
2018Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Three types of gut bacteria collaborating to improve Kui Jie'an enema treat DSS-induced colitis in mice.
2019Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Colonisation of the colonic mucus gel layer with butyrogenic and hydrogenotropic bacteria in health and ulcerative colitis.
2021Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus rhamnosus from human breast milk ameliorates ulcerative colitis in mice via gut microbiota modulation.
2021Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of ShenLing BaiZhu San Supplementation on Gut Microbiota and Oxidative Stress in Rats with Ulcerative Colitis.
2021Evidence-based complementary and alternative medicine : eCAM
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis.
2022Frontiers in veterinary science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polysaccharides from natural Cordyceps sinensis attenuated dextran sodium sulfate-induced colitis in C57BL/6J mice.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.
2023Journal of microbiology (Seoul, Korea)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of four characteristic carotenoids (lutein, β-carotene, lycopene, and astaxanthin) in alleviating DSS-induced colitis through gut microbiota regulation.
2025Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersImpact of Psychopathology and Gut Microbiota on Disease Progression in Ulcerative Colitis: A Five-Year Follow-Up Study.
2025Microorganisms
Relevant review or meta-analysis for the signal-disease area.