preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidmoderate inflation risk
Bilophila wadsworthia
inflammatory bowel disease
Bilophila wadsworthia is an interesting but still moderate-confidence signal in inflammatory bowel disease.
Bilophila wadsworthia shows a moderate evidence base in inflammatory bowel disease, with multiple central papers and additional supporting literature.
bilophila_wadsworthia
Credibility score
38
Human translation
3/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 38Human translation 3/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
12 papersDiversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease.
2012FEMS immunology and medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
2012Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
2015Digestive diseases (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.
2018PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut dysbiosis and clinical phases of pancolitis in patients with ulcerative colitis.
2021MicrobiologyOpen
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients.
2023EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Microbiome in Quiescent Crohn's Disease With Persistent Symptoms Show Disruptions in Microbial Sulfur and Tryptophan Pathways.
2024Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predicting Risk of Post-Treatment Relapse in Patients with Inflammatory Bowel Disease Based on Intestinal Microbiota.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue.
2026World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Geography-independent mucosal microbiota alterations in primary sclerosing cholangitis persist after liver transplantation.
2026JHEP reports : innovation in hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersThe Capacity to Produce Hydrogen Sulfide (H2S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome.
2021Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
13 papersIntestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis.
2013PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of the intestinal mucosal microbiota in dogs diagnosed with idiopathic inflammatory bowel disease and dogs with food-responsive diarrhea before and after treatment.
2018FEMS microbiology ecology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.
2018Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice.
2019Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota.
2020BMC gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Impact of dietary sulfolipid-derived sulfoquinovose on gut microbiota composition and inflammatory status of colitis-prone interleukin-10-deficient mice.
2021International journal of medical microbiology : IJMM
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structure-based identification of potential substrate antagonists for isethionate sulfite-lyase enzyme of Bilophila Wadsworthia: Towards novel therapeutic intervention to curb gut-associated illness.
2023International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.
2023Journal of microbiology (Seoul, Korea)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeted vaccine development against Bilophila wadsworthia to curb colon diseases: A multiepitope approach based on reverse vaccinology and computational analysis.
2023International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides thetaiotaomicron enhances H2S production in Bilophila wadsworthia.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fermented Kamut Wheat Diet Prevents DSS-Induced Colitis via Modulating Gut Microbiota in Mice.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lipoproteins from Bilophila wadsworthia cell wall induce innate immune responses through Toll-like receptor 2.
2025Anaerobe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersInflammation: a highly conserved, Janus-like phenomenon-a gastroenterologist' perspective.
2018Journal of molecular medicine (Berlin, Germany)
Relevant review or meta-analysis for the signal-disease area.