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supportedmidmoderate inflation risk

Bilophila wadsworthia

crohn's disease

Bilophila wadsworthia is an interesting but still moderate-confidence signal in crohn's disease.

Bilophila wadsworthia shows a moderate evidence base in crohn's disease, with multiple central papers and additional supporting literature.

bilophila_wadsworthia
Credibility score
44
Human translation
3/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 44Human translation 3/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
  • moderate central evidence base
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

14 papers
Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease.
2012
FEMS immunology and medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
2012
Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease.
2013
Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
2015
Digestive diseases (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.
2018
PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut dysbiosis and clinical phases of pancolitis in patients with ulcerative colitis.
2021
MicrobiologyOpen
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022
Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients.
2023
EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial signatures and their functions in Behcet's uveitis and Vogt-Koyanagi-Harada disease.
2023
Journal of autoimmunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024
Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Microbiome in Quiescent Crohn's Disease With Persistent Symptoms Show Disruptions in Microbial Sulfur and Tryptophan Pathways.
2024
Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predicting Risk of Post-Treatment Relapse in Patients with Inflammatory Bowel Disease Based on Intestinal Microbiota.
2025
Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue.
2026
World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Geography-independent mucosal microbiota alterations in primary sclerosing cholangitis persist after liver transplantation.
2026
JHEP reports : innovation in hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
The Capacity to Produce Hydrogen Sulfide (H2S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome.
2021
Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

14 papers
Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis.
2013
PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014
Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.
2018
Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice.
2019
Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota.
2020
BMC gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Impact of dietary sulfolipid-derived sulfoquinovose on gut microbiota composition and inflammatory status of colitis-prone interleukin-10-deficient mice.
2021
International journal of medical microbiology : IJMM
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency.
2021
Journal of biomedical science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis.
2022
Frontiers in veterinary science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structure-based identification of potential substrate antagonists for isethionate sulfite-lyase enzyme of Bilophila Wadsworthia: Towards novel therapeutic intervention to curb gut-associated illness.
2023
International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.
2023
Journal of microbiology (Seoul, Korea)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeted vaccine development against Bilophila wadsworthia to curb colon diseases: A multiepitope approach based on reverse vaccinology and computational analysis.
2023
International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides thetaiotaomicron enhances H2S production in Bilophila wadsworthia.
2024
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fermented Kamut Wheat Diet Prevents DSS-Induced Colitis via Modulating Gut Microbiota in Mice.
2025
International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lipoproteins from Bilophila wadsworthia cell wall induce innate immune responses through Toll-like receptor 2.
2025
Anaerobe
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

3 papers
Inflammation: a highly conserved, Janus-like phenomenon-a gastroenterologist' perspective.
2018
Journal of molecular medicine (Berlin, Germany)
Relevant review or meta-analysis for the signal-disease area.
The role of fecal sulfur metabolome in inflammatory bowel diseases.
2021
International journal of medical microbiology : IJMM
Relevant review or meta-analysis for the signal-disease area.
Impact of Psychopathology and Gut Microbiota on Disease Progression in Ulcerative Colitis: A Five-Year Follow-Up Study.
2025
Microorganisms
Relevant review or meta-analysis for the signal-disease area.