preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Bilophila wadsworthia
colorectal cancer
Bilophila wadsworthia has meaningful literature visibility in colorectal cancer, but the current evidence mix suggests a substantial risk of overclaiming.
Bilophila wadsworthia shows a moderate evidence base in colorectal cancer, with multiple central papers and additional supporting literature.
bilophila_wadsworthia
Credibility score
26
Human translation
2/5
Reproducibility
3/5
Novelty
4/5
Actionability
2/5
Credibility 26Human translation 2/5Reproducibility 3/5Novelty 4/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
5 papersShifts in the Fecal Microbiota Associated with Adenomatous Polyps.
2017Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal microorganisms involved in colorectal cancer complicated with dyslipidosis.
2019Cancer biology & therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model.
2019Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Emergence of rare and low abundant anaerobic gut Firmicutes is associated with a significant downfall of Klebsiella in human colon cancer.
2024Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The impact of enteral immunonutrition on gut microbiota in colorectal cancer and gastric cancer patients in the preoperative period-preliminary results of randomized clinical trial.
2025Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersThe Capacity to Produce Hydrogen Sulfide (H2S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome.
2021Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.
Barley polysaccharides inhibit colorectal cancer by two relatively independent pathways.
2024International journal of biological macromolecules
Human primary paper with plausible association relevance to the disease context.
Metabolic modeling and functional genomics reveal taxa and host gene interactions in colorectal cancer.
2026bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.
Preclinical supporting evidence
13 papersA metagenomic study of the preventive effect of Lactobacillus rhamnosus GG on intestinal polyp formation in ApcMin/+ mice.
2017Journal of applied microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Race-dependent association of sulfidogenic bacteria with colorectal cancer.
2017Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Functional Anthocyanin-Rich Sausages Diminish Colorectal Cancer in an Animal Model and Reduce Pro-Inflammatory Bacteria in the Intestinal Microbiota.
2018Genes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Culture-based bacterial evaluation of the appendix lumen in patients with and without acute appendicitis.
2019Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Traditional Processed Meat Products Re-designed Towards Inulin-rich Functional Foods Reduce Polyps in Two Colorectal Cancer Animal Models.
2019Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of herbal medicine daikenchuto on gastrointestinal symptoms following laparoscopic colectomy in patients with colon cancer: A prospective randomized study.
2021Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structure-based identification of potential substrate antagonists for isethionate sulfite-lyase enzyme of Bilophila Wadsworthia: Towards novel therapeutic intervention to curb gut-associated illness.
2023International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Isethionate is an intermediate in the degradation of sulfoacetate by the human gut pathobiont Bilophila wadsworthia.
2023The Journal of biological chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeted vaccine development against Bilophila wadsworthia to curb colon diseases: A multiepitope approach based on reverse vaccinology and computational analysis.
2023International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacterial cysteate dissimilatory pathway involves a racemase and d-cysteate sulfo-lyase.
2024The Journal of biological chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alteration of ascending colon mucosal microbiota in patients after cholecystectomy.
2024World journal of gastrointestinal surgery
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides thetaiotaomicron enhances H2S production in Bilophila wadsworthia.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut colonization of Bacteroides plebeius suppresses colitis-associated colon cancer development.
2025Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersThe gut microbiome and colorectal cancer: a review of bacterial pathogenesis.
2018Journal of gastrointestinal oncology
Relevant review or meta-analysis for the signal-disease area.
The role of fecal sulfur metabolome in inflammatory bowel diseases.
2021International journal of medical microbiology : IJMM
Relevant review or meta-analysis for the signal-disease area.
Role of sulfidogenic members of the gut microbiota in human disease.
2024Advances in microbial physiology
Relevant review or meta-analysis for the signal-disease area.
Advances in microbial sulfoquinovose catabolism.
2026Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.