review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Bifidobacterium
obesity
Bifidobacterium looks like a credible signal in obesity, though some caution is still warranted.
Bifidobacterium shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
bifidobacterium
Credibility score
72
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 72Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
17 papersProbiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial.
2016EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity.
2020Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity.
2020Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Synbiotic Supplementation on Chronic Inflammation and the Gut Microbiota in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial.
2022Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Fecal Microbiota Transplantation on Gut Bacterial Bile Acid Metabolism in Humans.
2022Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.
2023EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
IMMUNOLOGICAL DISORDERS AND COLON DYSBIOSIS IN OBESE PATIENTS WITH HYPOTHYROIDISM.
2023Wiadomosci lekarskie (Warsaw, Poland : 1960)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota.
2024Nature metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Bifidobacterium breve 207-1 on regulating lifestyle behaviors and mental wellness in healthy adults based on the microbiome-gut-brain axis: a randomized, double-blind, placebo-controlled trial.
2024European journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.
2024International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of Intake of Bifidobacteria and Dietary Fiber on Resting Energy Expenditure: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparison Study.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels.
2024Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-Omics Exploration of Obesity Biomarkers in Sedentary and Weight Loss Cohorts.
2025Phenomics (Cham, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The ecology of the microbiota in children with obesity is associated with the intake of carbohydrates and insulin resistance.
2025Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
5 papersChanges in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.
2008Diabetes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.
2020The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multiomics reveals the ameliorating effect and underlying mechanism of aqueous extracts of polygonatum sibiricum rhizome on obesity and liver fat accumulation in high-fat diet-fed mice.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Betaine and Polydextrose on Intestinal Microbiota and Liver Ergothioneine in a High-Fat Diet-Fed Mouse Model and a Human Colonic Simulation Model.
2024Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Deconjugating taurocholic acid with Bifidobacterium to mitigate obesity-driven cancer progression by restoring CD8+ T-cell infiltration.
2025NPJ biofilms and microbiomes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
34 papersCarbohydrates and the human gut microbiota.
2013Current opinion in clinical nutrition and metabolic care
Relevant review or meta-analysis for the signal-disease area.
Probiotics: an update.
2015Jornal de pediatria
Relevant review or meta-analysis for the signal-disease area.
The Relationship Between the Human Genome and Microbiome Comes into View.
2017Annual review of genetics
Relevant review or meta-analysis for the signal-disease area.
Probiotic Species in the Modulation of Gut Microbiota: An Overview.
2018BioMed research international
Relevant review or meta-analysis for the signal-disease area.
Microbial enterotypes in personalized nutrition and obesity management.
2018The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Is It Time to Use Probiotics to Prevent or Treat Obesity?
2018Nutrients
Relevant review or meta-analysis for the signal-disease area.
Probiotics: How Effective Are They in the Fight against Obesity?
2019Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome: Profound Implications for Diet and Disease.
2019Nutrients
Relevant review or meta-analysis for the signal-disease area.
Immunonutritional contribution of gut microbiota to fatty liver disease.
2020Nutricion hospitalaria
Relevant review or meta-analysis for the signal-disease area.
Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives.
2020Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Probiotics for the Treatment of Overweight and Obesity in Humans-A Review of Clinical Trials.
2020Microorganisms
Relevant review or meta-analysis for the signal-disease area.
The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
2020Nutrients
Relevant review or meta-analysis for the signal-disease area.
Effects of Probiotics and Synbiotics on Weight Loss in Subjects with Overweight or Obesity: A Systematic Review.
2021Nutrients
Relevant review or meta-analysis for the signal-disease area.
Probiotics: Should All Patients Take Them?
2021Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.
2021Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Changes in the Gut Microbiome and Pathologies in Pregnancy.
2022International journal of environmental research and public health
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs.
2022The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
Review and Perspectives on Bifidobacterium lactis for Infants' and Children's Health.
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Prebiotics, Probiotics, and Synbiotics-A Research Hotspot for Pediatric Obesity.
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift.
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Understanding how pre- and probiotics affect the gut microbiome and metabolic health.
2024American journal of physiology. Endocrinology and metabolism
Relevant review or meta-analysis for the signal-disease area.
Exploration of the Muribaculaceae Family in the Gut Microbiota: Diversity, Metabolism, and Function.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders.
2024Cells
Relevant review or meta-analysis for the signal-disease area.
Health Effects and Mechanisms of Inulin Action in Human Metabolism.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
The anti-obesity effects of postbiotics: A systematic review of pre-clinical and clinical studies.
2024Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.
Association between gut microbiota and pediatric obesity: A systematic review.
2025Nutrition (Burbank, Los Angeles County, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Infant gut microbiota and functional foods: Opportunities for early health intervention.
2025Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
Precision probiotics for overweight management: decoding strain-specific mechanisms to guide microbiota-tailored interventions.
2026Food & function
Relevant review or meta-analysis for the signal-disease area.