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supportedtopmoderate inflation risk

Bifidobacterium

autism

Bifidobacterium is an interesting but still moderate-confidence signal in autism.

Bifidobacterium shows a moderate evidence base in autism, with multiple central papers and additional supporting literature.

bifidobacterium
Credibility score
53
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 53Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
  • moderate central evidence base
  • dense review literature
Main caveats
  • directionality and confounding still require curated review

Internal review flags

1 flags
review_heavy

Review literature is very dense relative to primary central evidence.

Primary central evidence

12 papers
Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
2019
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder.
2020
Pharmacological research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Age and severity-dependent gut microbiota alterations in Tunisian children with autism spectrum disorder.
2023
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study.
2024
Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.
2025
Autism research : official journal of the International Society for Autism Research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Synbiotic combination of 2'-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid.
2025
Food & function
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and urine metabolomics signature in autism spectrum disorder children from Southern China.
2025
BMC pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in children and adolescents with autism, ADHD and anorexia nervosa, and its link to the levels of satiety hormones.
2025
Neuroscience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Anti-Inflammatory Diet and Probiotic Supplementation as Strategies to Modulate Immune Dysregulation in Autism Spectrum Disorder.
2025
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered gut microbiota composition and feeding behaviours in children with Autism Spectrum Disorder: a comparative pilot study.
2025
Annals of human biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota characteristics and therapeutic effects of fecal microbiota transplantation in children with autism spectrum disorder in central China: a combined cross-sectional and prospective study.
2025
Frontiers in pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Preclinical supporting evidence

6 papers
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.
2017
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.
2019
PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles.
2023
Nature neuroscience
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and clinical characteristics of individuals with autism spectrum disorder differ depending on the ecological structure of the gut microbiome.
2024
Psychiatry research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of Lactiplantibacillus plantarum intervention.
2024
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions.
2025
Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

26 papers
Gut microbiota and pediatric disease.
2011
Digestive diseases (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review.
2019
Translational psychiatry
Relevant review or meta-analysis for the signal-disease area.
A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders.
2019
Medicina (Kaunas, Lithuania)
Relevant review or meta-analysis for the signal-disease area.
Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders.
2019
Journal of food and drug analysis
Relevant review or meta-analysis for the signal-disease area.
Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
2019
Frontiers in psychiatry
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota changes in children with autism spectrum disorder: a systematic review.
2020
Gut pathogens
Relevant review or meta-analysis for the signal-disease area.
Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
2020
Nutrients
Relevant review or meta-analysis for the signal-disease area.
A systematic review of microbiome changes and impact of probiotic supplementation in children and adolescents with neuropsychiatric disorders.
2021
Progress in neuro-psychopharmacology & biological psychiatry
Relevant review or meta-analysis for the signal-disease area.
A Meta-analysis of Gut Microbiota in Children with Autism.
2022
Journal of autism and developmental disorders
Relevant review or meta-analysis for the signal-disease area.
Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.
2022
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Profiles in Children and Adolescents with Psychiatric Disorders.
2022
Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases.
2022
Nutrients
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
2023
Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Emerging Role and Place of Probiotics in the Management of Pediatric Neurodevelopmental Disorders.
2022
Euroasian journal of hepato-gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Genus-Level Analysis of Gut Microbiota in Children with Autism Spectrum Disorder: A Mini Review.
2023
Children (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Microbiota in Autism Spectrum Disorder: A Systematic Review.
2023
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
A comparison between children and adolescents with autism spectrum disorders and healthy controls in biomedical factors, trace elements, and microbiota biomarkers: a meta-analysis.
2023
Frontiers in psychiatry
Relevant review or meta-analysis for the signal-disease area.
Probiotics in autism spectrum disorder: Recent insights from animal models.
2024
Autism : the international journal of research and practice
Relevant review or meta-analysis for the signal-disease area.
Revealing the gut microbiome mystery: A meta-analysis revealing differences between individuals with autism spectrum disorder and neurotypical children.
2024
Bioscience trends
Relevant review or meta-analysis for the signal-disease area.
The gut microbiome in children with mood, anxiety, and neurodevelopmental disorders: An umbrella review.
2023
Gut microbiome (Cambridge, England)
Relevant review or meta-analysis for the signal-disease area.
Microbiome's effect on white matter in autism.
2025
Journal of neurophysiology
Relevant review or meta-analysis for the signal-disease area.
Mechanistic Links Between Gut Dysbiosis, Insulin Resistance, and Autism Spectrum Disorder.
2025
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Microbiota Gut-Brain Axis and Autism Spectrum Disorder: Mechanisms and Therapeutic Perspectives.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota and Autism: Unlocking Connections.
2025
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Effect of multispecies probiotics on autism symptoms: protocol for a randomized controlled trial (PROBAUT).
2025
Trials
Relevant review or meta-analysis for the signal-disease area.
Exploring the links between nutrition, gut microbiome, and neurodevelopmental disorders.
2025
Nutrition (Burbank, Los Angeles County, Calif.)
Relevant review or meta-analysis for the signal-disease area.