review_heavy
Review literature is very dense relative to primary central evidence.
fulltoplow inflation risk
Bifidobacterium
atopic dermatitis
Bifidobacterium looks like a credible signal in atopic dermatitis, though some caution is still warranted.
Bifidobacterium shows a strong literature footprint in atopic dermatitis, with substantial central evidence and broader supporting literature.
bifidobacterium
Credibility score
73
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
4/5
Credibility 73Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
18 papersDifferences in fecal microflora between patients with atopic dermatitis and healthy control subjects.
2003The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention.
2008Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Probiotics reduce gut microbial translocation and improve adult atopic dermatitis.
2012Journal of clinical gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type.
2018The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study.
2018International archives of allergy and immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture.
2019Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study.
2020European journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil.
2020Allergologia et immunopathologia
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Nutrition and Atopic Dermatitis.
2021Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis.
2022Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study.
2022Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study.
2023Frontiers in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dupilumab therapy improves gut microbiome dysbiosis and tryptophan metabolism in Chinese patients with atopic dermatitis.
2024International immunopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Antibiotics taken within the first year of life are linked to infant gut microbiome disruption and elevated atopic dermatitis risk.
2024The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.
2024Food science of animal resources
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interpretable machine learning algorithms reveal gut microbiome features associated with atopic dermatitis.
2025Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Next-Generation Probiotics in Allergy Therapy: Scientific Evidence and Clinical Applications.
2025Anti-inflammatory & anti-allergy agents in medicinal chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication.
2025Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersHost-microbial interactions between PTGR2 and Bifidobacterium in the early life gut of atopic dermatitis children.
2022Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Human primary paper with plausible association relevance to the disease context.
The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis.
2022Frontiers in cellular and infection microbiology
Human primary paper with plausible association relevance to the disease context.
Early-life colonization by aromatic-lactate-producing bifidobacteria lowers the risk of allergic sensitization.
2026Nature microbiology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
16 papersEffect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial.
2018JAMA dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study.
2021Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacterium longum and Galactooligosaccharide Improve Skin Barrier Dysfunction and Atopic Dermatitis-like Skin.
2022Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Randomized double-blind placebo-controlled clinical trial to evaluate the effect of a mixture of probiotic strains on symptom severity and use of corticosteroids in children and adolescents with atopic dermatitis.
2023Clinical and experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old.
2023Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders.
2024Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota profile and atopic dermatitis in the first year of life.
2024Journal of medicine and life
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Chickpea-resistant starch exhibits bioactive function for alleviating atopic dermatitis via regulating butyrate production.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Supplementation with a Specific Probiotic (Bifidobacterium bifidum PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
2'-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated multi-omics reveals different host crosstalk of atopic dermatitis-enriched Bifidobacterium longum Strains.
2025NPJ biofilms and microbiomes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis.
2025Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.
2025Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Strain-Level Differences of Bifidobacterium breve in the Gut Microbiome between Infants with and without Atopic Dermatitis: Insights from Genome Analysis and Immune Assays.
2025Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice.
2026Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacterium breve CCFM1078 alleviates DNFB-induced atopic dermatitis in early-life via AhR activation, Th1/Th2 immune modulation, and gut microbiota regulation.
2026Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
20 papersThe role of probiotics and prebiotics in pediatric practice.
2006Jornal de pediatria
Relevant review or meta-analysis for the signal-disease area.
Pediatric applications of inulin and oligofructose.
2007The Journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials.
2008American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
Probiotics in allergy management.
2008Journal of pediatric gastroenterology and nutrition
Relevant review or meta-analysis for the signal-disease area.
Probiotics.
2008American family physician
Relevant review or meta-analysis for the signal-disease area.
Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies.
2015Journal of the European Academy of Dermatology and Venereology : JEADV
Relevant review or meta-analysis for the signal-disease area.
An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis.
2018International journal of dermatology
Relevant review or meta-analysis for the signal-disease area.
Mechanisms of Action of Probiotics.
2019Advances in nutrition (Bethesda, Md.)
Relevant review or meta-analysis for the signal-disease area.
Topical probiotics: the unknowns behind their rising popularity.
2019Dermatology online journal
Relevant review or meta-analysis for the signal-disease area.
Effects of probiotics in the treatment of food hypersensitivity in children: a systematic review.
2020Allergologia et immunopathologia
Relevant review or meta-analysis for the signal-disease area.
Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: A systematic review and network meta-analysis.
2021Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Relevant review or meta-analysis for the signal-disease area.
Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: A systematic review and network meta-analysis.
2021Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Relevant review or meta-analysis for the signal-disease area.
Recent advances in the concept of paraprobiotics: Nutraceutical/functional properties for promoting children health.
2023Critical reviews in food science and nutrition
Relevant review or meta-analysis for the signal-disease area.
The efficacy of probiotics supplementation for the treatment of atopic dermatitis in adults: a systematic review and meta-analysis.
2022The Journal of dermatological treatment
Relevant review or meta-analysis for the signal-disease area.
Role of human milk oligosaccharide metabolizing bacteria in the development of atopic dermatitis/eczema.
2023Frontiers in pediatrics
Relevant review or meta-analysis for the signal-disease area.
The Interaction between the Host Genome, Epigenome, and the Gut-Skin Axis Microbiome in Atopic Dermatitis.
2023International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Gut Dysbiosis and Adult Atopic Dermatitis: A Systematic Review.
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Infant gut microbiota and functional foods: Opportunities for early health intervention.
2025Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
From Gut Dysbiosis to Skin Inflammation in Atopic Dermatitis: Probiotics and the Gut-Skin Axis-Clinical Outcomes and Microbiome Implications.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
The Emerging Role of Gut Microbiota in Inflammatory Skin Diseases: A Systematic Review.
2026Experimental dermatology
Relevant review or meta-analysis for the signal-disease area.