preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Bacteroides vulgatus
ulcerative colitis
Bacteroides vulgatus has meaningful literature visibility in ulcerative colitis, but the current evidence mix suggests a substantial risk of overclaiming.
Bacteroides vulgatus shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.
bacteroides_vulgatus
Credibility score
94
Human translation
2/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 94Human translation 2/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
2 flagssparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
Primary central evidence
30 papersCharacterization of antibody responses against rectal mucosa-associated bacterial flora in patients with ulcerative colitis.
2000Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative analysis of bacterial DNA from Mycobacteria spp., Bacteroides vulgatus, and Escherichia coli in tissue samples from patients with inflammatory bowel diseases.
2002Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis.
2006Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
2007Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique.
1991Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
OmpA variants affecting the adherence of ulcerative colitis-derived Bacteroides vulgatus.
2010Journal of medical and dental sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota.
2010BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut bacterium and pathobiont Bacteroides vulgatus activates NF-κB in a human gut epithelial cell line in a strain and growth phase dependent manner.
2017Anaerobe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
2017Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.
2018Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment.
2019Cell death & disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal flora alterations in patients with ulcerative colitis and their association with inflammation.
2021Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.
2022Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of gut microbiome and transcriptome changes in ulcerative colitis and pouchitis.
2022Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Location-specific signatures of Crohn's disease at a multi-omics scale.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of gut Microbiome alteration in Ulcerative Colitis patients on disease severity and outcome.
2023Clinical and experimental medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation.
2023Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.
2024Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Berberine regulates intestinal microbiome and metabolism homeostasis to treat ulcerative colitis.
2024Life sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis.
2024Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differential contributions of the gut microbiota and metabolome to pathomechanisms in ulcerative colitis: an in vitro analysis.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in amino acid concentrations and the gut microbiota composition are implicated in the mucosal healing of ulcerative colitis and can be used as noninvasive diagnostic biomarkers.
2024Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patient-donor similarity and donor-derived species contribute to the outcome of fecal microbiota transplantation for ulcerative colitis.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolomic Signatures Highlight Fiber-Degrading Bacteroides Species in Mediterranean Diet Response Among Ulcerative Colitis.
2025Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Production of erosions and ulcers of the colon in Syrian hamsters with Bacteroides vulgatus isolated from the fecal microflora of human ulcerative colitis].
1985Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
35 papersPrevention of gut inflammation by Bifidobacterium in dextran sulfate-treated gnotobiotic mice associated with Bacteroides strains isolated from ulcerative colitis patients.
2003Microbes and infection
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cells.
2004Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease.
2006Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis.
2009Journal of medical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
2009PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis.
2017Gut pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota.
2021International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule.
2021The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
2'-Fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression.
2022Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Study of the gut microbiome in Egyptian patients with active ulcerative colitis.
2023Revista de gastroenterologia de Mexico (English)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis.
2022Frontiers in veterinary science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coptis chinensis and Berberine Ameliorate Chronic Ulcerative Colitis: An Integrated Microbiome-Metabolomics Study.
2023The American journal of Chinese medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of Bacteroides vulgatus strains in the enhancement of experimental ulcerative colitis.
1987Infection and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis by reshaping gut microbiota, especially by boosting the anti-colitic Bacteroides thetaiotaomicron.
2024Pharmacological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids.
2024Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The roles of different Bacteroides uniformis strains in alleviating DSS-induced ulcerative colitis and related functional genes.
2024Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Atorvastatin improved ulcerative colitis in association with gut microbiota-derived tryptophan metabolism.
2024Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coptisine alleviates colitis through modulating gut microbiota and inhibiting TXNIP/NLRP3 inflammasome.
2024Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides fragilis in saliva: investigating links with ulcerative colitis.
2024Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polyphenols-rich Portulaca oleracea L. (purslane) alleviates ulcerative colitis through restiring the intestinal barrier, gut microbiota and metabolites.
2025Food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota.
2024Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin Alleviates Ulcerative Colitis in Mice by Modulating Gut Microbiota and Plasma Metabolism.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Serogrouping of Bacteroides vulgatus by the agglutination test.
1985Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota-related glutathione metabolism is key mechanism for sulforaphane ameliorating ulcerative colitis.
2025The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Beneficial Effects of Apple Polyphenol Extract and Time-Restricted Feeding on Ulcerative Colitis and Accompanying Depression-like Behaviors Are Correlated with Gut-Brain Axis Modulation.
2025Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kaji-ichigoside F1 alleviates the effect of ulcerative colitis: An integrated strategy of gut microbiota, metabolomics, and transcriptomics.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Akkermansia muciniphila-derived extracellular vesicles alleviate colitis-related cognitive impairment via tryptophan metabolic reprogramming of the gut‒brain axis.
2026Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Adoptive transfer of immune enhancement of experimental ulcerative colitis.
1984Infection and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The pathogenic role of Bacteroides vulgatus in patients with ulcerative colitis.
1995Journal of gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antibodies detectable by counterimmunoelectrophoresis against Bacteroides antigens in serum of patients with inflammatory bowel disease.
1979Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
6 papersIntestinal bacteria and ulcerative colitis.
2003Current issues in intestinal microbiology
Relevant review or meta-analysis for the signal-disease area.
Update on the etiology, pathogenesis and diagnosis of ulcerative colitis.
2004Nature clinical practice. Gastroenterology & hepatology
Relevant review or meta-analysis for the signal-disease area.
Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis.
2022EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Pathobionts in Inflammatory Bowel Disease: Origins, Underlying Mechanisms, and Implications for Clinical Care.
2024Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota-based discovery of Houttuyniae Herba as a novel prebiotic of Bacteroides thetaiotaomicron with anti-colitis activity.
2024Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Relevant review or meta-analysis for the signal-disease area.