preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Bacteroides vulgatus
inflammatory bowel disease
Bacteroides vulgatus has meaningful literature visibility in inflammatory bowel disease, but the current evidence mix suggests a substantial risk of overclaiming.
Bacteroides vulgatus shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
bacteroides_vulgatus
Credibility score
70
Human translation
2/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 70Human translation 2/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- retrieval noise or disease-specificity issues may remain
Internal review flags
2 flagshigh_exclusion_volume
Many retrieved papers were excluded. Retrieval may be broad or disease specificity may be noisy.
Primary central evidence
21 papersComparison of the faecal microflora of patients with ankylosing spondylitis and controls using molecular methods of analysis.
2002Rheumatology (Oxford, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial-induced inflammation in germ-free rabbit appendix.
2005Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
2007Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique.
1991Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Azathioprine, Mercaptopurine, and 5-Aminosalicylic Acid Affect the Growth of IBD-Associated Campylobacter Species and Other Enteric Microbes.
2017Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.
2018Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.
2022Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Location-specific signatures of Crohn's disease at a multi-omics scale.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation.
2023Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inflammatory bowel disease biomarkers revealed by the human gut microbiome network.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
MiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis.
2025Metabolites
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Human colitis-associated colorectal carcinoma progression is accompanied by dysbiosis with enriched pathobionts.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolomic Signatures Highlight Fiber-Degrading Bacteroides Species in Mediterranean Diet Response Among Ulcerative Colitis.
2025Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics integration reveals functional signatures of gut microbiome in atherosclerosis.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of Bacteroides vulgatus.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersProduction of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine.
2014World journal of gastroenterology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
35 papersAlteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice.
2000Journal of immunology (Baltimore, Md. : 1950)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease.
2003Microbiology and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sulphasalazine fails to prevent development of mucosal ulceration and 5-lipoxygenase activity in guinea-pigs with chronic inflammatory bowel disease induced by combined bacterial immunization and oral carrageenin.
1992The Journal of pharmacy and pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association with selected bacteria does not cause enterocolitis in IL-10 gene-deficient mice despite a systemic immune response.
2005Digestive diseases and sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease.
2006Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Inflammatory bowel disease induced by combined bacterial immunization and oral carrageenan in guinea pigs. Model development, histopathology, and effects of sulfasalazine.
1991Digestive diseases and sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Therapeutic effects of roxithromycin in interleukin-10-deficient colitis.
2007Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
2009PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
2017Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galleria mellonella: A Novel Invertebrate Model to Distinguish Intestinal Symbionts From Pathobionts.
2018Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Weak Agonistic LPS Restores Intestinal Immune Homeostasis.
2019Molecular therapy : the journal of the American Society of Gene Therapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses.
2019Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Commensal-Induced IκBζ Expression in Dendritic Cells Influences the Th17 Response.
2020Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule.
2021The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
2'-Fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression.
2022Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Discovery of bioactive microbial gene products in inflammatory bowel disease.
2022Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel Potassium-Competitive Acid Blocker, Tegoprazan, Protects Against Colitis by Improving Gut Barrier Function.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Heat-Killed Bifidobacterium bifidum B1628 May Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, and the Anti-Inflammatory Effect Is Associated with Gut Microbiota Modulation.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides vulgatus alleviates dextran sodium sulfate-induced colitis and depression-like behaviour by facilitating gut-brain axis balance.
2023Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Crataegus pinnatifida Bunge Variety-Daehong.
2024Antioxidants (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules.
2025Journal of controlled release : official journal of the Controlled Release Society
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polysaccharides from Cistanche deserticola mitigate inflammatory bowel disease via modulating intestinal microbiota and SRC/EGFR/PI3K/AKT signaling pathways.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation.
2025Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eubacterium limosum modulates gut microbiota and produces anti-inflammatory metabolites to alleviate DSS-induced colitis.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Akkermansia muciniphila-derived extracellular vesicles alleviate colitis-related cognitive impairment via tryptophan metabolic reprogramming of the gut‒brain axis.
2026Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Adoptive transfer of immune enhancement of experimental ulcerative colitis.
1984Infection and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antibodies detectable by counterimmunoelectrophoresis against Bacteroides antigens in serum of patients with inflammatory bowel disease.
1979Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
7 papersThe microbiota and inflammatory bowel disease: insights from animal models.
2013Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Pathobionts in Inflammatory Bowel Disease: Origins, Underlying Mechanisms, and Implications for Clinical Care.
2024Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go?
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.