preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Bacteroides vulgatus
crohn's disease
Bacteroides vulgatus has meaningful literature visibility in crohn's disease, but the current evidence mix suggests a substantial risk of overclaiming.
Bacteroides vulgatus shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
bacteroides_vulgatus
Credibility score
84
Human translation
2/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 84Human translation 2/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- retrieval noise or disease-specificity issues may remain
Internal review flags
2 flagshigh_exclusion_volume
Many retrieved papers were excluded. Retrieval may be broad or disease specificity may be noisy.
Primary central evidence
25 papersQuantitative analysis of bacterial DNA from Mycobacteria spp., Bacteroides vulgatus, and Escherichia coli in tissue samples from patients with inflammatory bowel diseases.
2002Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of the faecal microflora of patients with ankylosing spondylitis and controls using molecular methods of analysis.
2002Rheumatology (Oxford, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
2007Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique.
1991Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Molecular inventory of faecal microflora in patients with Crohn's disease.
2004FEMS microbiology ecology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC.
2017Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Azathioprine, Mercaptopurine, and 5-Aminosalicylic Acid Affect the Growth of IBD-Associated Campylobacter Species and Other Enteric Microbes.
2017Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
2017Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative microbiome profiling links gut community variation to microbial load.
2017Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.
2018Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inter-kingdom relationships in Crohn's disease explored using a multi-omics approach.
2021Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.
2022Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Location-specific signatures of Crohn's disease at a multi-omics scale.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Increased faecal glycosidases in patients with Crohn's disease.
1987Digestion
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation.
2023Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease.
2024Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease.
2024Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
MiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis.
2025Metabolites
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolomic Signatures Highlight Fiber-Degrading Bacteroides Species in Mediterranean Diet Response Among Ulcerative Colitis.
2025Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of Bacteroides vulgatus.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersOlfactomedin-4 is a glycoprotein secreted into mucus in active IBD.
2012Journal of Crohn's & colitis
Human primary paper with plausible association relevance to the disease context.
Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine.
2014World journal of gastroenterology
Human primary paper with plausible association relevance to the disease context.
Dysbiosis in a canine model of human fistulizing Crohn's disease.
2020Gut microbes
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
34 papersAlteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice.
2000Journal of immunology (Baltimore, Md. : 1950)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structural elucidation of a capsular polysaccharide from a clinical isolate of Bacteroides vulgatus from a patient with Crohn's disease.
2001European journal of biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structural study on lipid A and the O-specific polysaccharide of the lipopolysaccharide from a clinical isolate of Bacteroides vulgatus from a patient with Crohn's disease.
2002European journal of biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice.
2003Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease.
2003Microbiology and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cells.
2004Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease.
2006Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Epithelial barrier disruption allows nondisease-causing bacteria to initiate and sustain IBD in the IL-10 gene-deficient mouse.
2007Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
2009PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.
2014Immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation.
2016Chemical communications (Cambridge, England)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
2017Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Weak Agonistic LPS Restores Intestinal Immune Homeostasis.
2019Molecular therapy : the journal of the American Society of Gene Therapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses.
2019Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
2'-Fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression.
2022Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Discovery of bioactive microbial gene products in inflammatory bowel disease.
2022Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel Potassium-Competitive Acid Blocker, Tegoprazan, Protects Against Colitis by Improving Gut Barrier Function.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Heat-Killed Bifidobacterium bifidum B1628 May Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, and the Anti-Inflammatory Effect Is Associated with Gut Microbiota Modulation.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides vulgatus alleviates dextran sodium sulfate-induced colitis and depression-like behaviour by facilitating gut-brain axis balance.
2023Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Crataegus pinnatifida Bunge Variety-Daehong.
2024Antioxidants (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis ameliorates pro-inflammatory diet-exacerbated colitis by targeting endoplasmic reticulum stress-mediated ferroptosis.
2025Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules.
2025Journal of controlled release : official journal of the Controlled Release Society
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.
2025Behavioral and brain functions : BBF
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multiomics Analysis of Bacteroides cellulosilyticus Anticolitis via Gut Microbiota Metabolite-Mediated PI3K-Akt Signaling Pathway.
2025Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eubacterium limosum modulates gut microbiota and produces anti-inflammatory metabolites to alleviate DSS-induced colitis.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
8 papers[Intestinal flora and Crohn's disease].
2003Annales pharmaceutiques francaises
Relevant review or meta-analysis for the signal-disease area.
Role of antibiotics for treatment of inflammatory bowel disease.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Pathobionts in Inflammatory Bowel Disease: Origins, Underlying Mechanisms, and Implications for Clinical Care.
2024Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go?
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.