review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Bacteroides vulgatus
colorectal cancer
Bacteroides vulgatus looks like a credible signal in colorectal cancer, though some caution is still warranted.
Bacteroides vulgatus shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.
bacteroides_vulgatus
Credibility score
74
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 74Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
19 papersQuantitative analysis of bacterial DNA from Mycobacteria spp., Bacteroides vulgatus, and Escherichia coli in tissue samples from patients with inflammatory bowel diseases.
2002Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers.
2012The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.
2017Science (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
2018Science (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment.
2019Cell death & disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mutated CEACAMs Disrupt Transforming Growth Factor Beta Signaling and Alter the Intestinal Microbiome to Promote Colorectal Carcinogenesis.
2020Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer.
2020Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploring Gut Microbiota in Patients with Colorectal Disease Based on 16S rRNA Gene Amplicon and Shallow Metagenomic Sequencing.
2021Frontiers in molecular biosciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer.
2023Cancer cell
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial dynamics with CRC progression: a study of the mucosal microbiota at multiple sites in cancers, adenomatous polyps, and healthy controls.
2023European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.
2023Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic analysis of fecal samples in colorectal cancer Egyptians patients post colectomy: A pilot study.
2024AIMS microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer.
2024Med (New York, N.Y.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk.
2024Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
KAJF alleviated colorectal cancer liver metastasis by reshaping the gut microbiota and inhibiting M2-like macrophage polarization.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Temporal network analysis of gut microbiota unveils aging trajectories associated with colon cancer.
2025mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota dysbiosis in people living with HIV who have cancer: novel insights and diagnostic potential.
2025Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
15 papersModulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
2009PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Carcinogenesis and Gut Microbiota].
2019Gan to kagaku ryoho. Cancer & chemotherapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout.
2021Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Alteration Influences Colorectal Cancer Metastasis to the Liver by Remodeling the Liver Immune Microenvironment.
2022Gut and liver
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Interaction between Bacteria and the Immune System for Cancer Immunotherapy: The α-GalCer Alliance.
2022International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered gut microbiome composition by appendectomy contributes to colorectal cancer.
2023Oncogene
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice.
2023EBioMedicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Aging characteristics of colorectal cancer based on gut microbiota.
2023Cancer medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association between gut microbiota and CpG island methylator phenotype in colorectal cancer.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway.
2024iMeta
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.
2024Science advances
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity.
2025Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression.
2025Cell metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity.
2026Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
25 papersGut microbiota imbalance and colorectal cancer.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota, Inflammation, and Colorectal Cancer.
2016Annual review of microbiology
Relevant review or meta-analysis for the signal-disease area.
Food, microbiome and colorectal cancer.
2018Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications.
2019Nature reviews. Gastroenterology & hepatology
Relevant review or meta-analysis for the signal-disease area.
The Four Horsemen in Colon Cancer.
2019Journal of oncology
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease and Microbiome.
2020Microorganisms
Relevant review or meta-analysis for the signal-disease area.
The Intestinal Microbiota and Colorectal Cancer.
2020Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota-derived metabolites in CRC progression and causation.
2021Journal of cancer research and clinical oncology
Relevant review or meta-analysis for the signal-disease area.
Tumorigenic bacteria in colorectal cancer: mechanisms and treatments.
2021Cancer biology & medicine
Relevant review or meta-analysis for the signal-disease area.
The gastrointestinal microbiota in colorectal cancer cell migration and invasion.
2021Clinical & experimental metastasis
Relevant review or meta-analysis for the signal-disease area.
Microbe-based management for colorectal cancer.
2021Chinese medical journal
Relevant review or meta-analysis for the signal-disease area.
Carcinogenic microbiota and its role in colorectal cancer development.
2022Seminars in cancer biology
Relevant review or meta-analysis for the signal-disease area.
Colorectal cancer: the facts in the case of the microbiota.
2022The Journal of clinical investigation
Relevant review or meta-analysis for the signal-disease area.
Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences.
2022World journal of gastrointestinal oncology
Relevant review or meta-analysis for the signal-disease area.
Meta-Analysis of Altered Gut Microbiota Reveals Microbial and Metabolic Biomarkers for Colorectal Cancer.
2022Microbiology spectrum
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities.
2023Cancers
Relevant review or meta-analysis for the signal-disease area.
Intestinal bacteria and colorectal cancer: etiology and treatment.
2023Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer.
2023Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Relevant review or meta-analysis for the signal-disease area.
Colorectal cancer and gut microbiota studies in China.
2023Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Colorectal cancer and microbiota: systematic review.
2024Przeglad gastroenterologiczny
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Intestinal dysbiosis and colorectal cancer.
2025Chinese medical journal
Relevant review or meta-analysis for the signal-disease area.
Emerging New Treatments for Colon Cancer.
2025Current medicinal chemistry
Relevant review or meta-analysis for the signal-disease area.