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Bacteroides uniformis

type 2 diabetes

Bacteroides uniformis looks like a credible signal in type 2 diabetes, though some caution is still warranted.

Bacteroides uniformis shows a strong literature footprint in type 2 diabetes, with substantial central evidence and broader supporting literature.

bacteroides_uniformis
Credibility score
78
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 78Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

25 papers
Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment.
2019
Cell death & disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India.
2021
Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of the gut microbiome in patients with prediabetes and type 2 diabetes.
2021
PeerJ
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic analysis revealed the potential role of gut microbiome in gout.
2021
NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Kazak faecal microbiota transplantation induces short-chain fatty acids that promote glucagon-like peptide-1 secretion by regulating gut microbiota in db/db mice.
2021
Pharmaceutical biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mechanism research on the interaction regulation of Escherichia and IFN-γ for the occurrence of T2DM.
2021
Annals of palliative medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Bacterial Community and Metagenome Function in Asians with Type 2 Diabetes, According to Enterotypes.
2022
Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of Gut Microbiota Composition in Type 2 Diabetes Patients: A Population-Based Study.
2022
International journal of environmental research and public health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in patients with COVID-19 and type 2 diabetes: A culture-based method.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the Gut Microbiota in Pregnant Women with Pregestational Type 2 Diabetes Mellitus.
2023
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Jiang-Tang-San-Huang pill alleviates type 2 diabetes mellitus through modulating the gut microbiota and bile acids metabolism.
2023
Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the Microbiota and their Roles in Patients with Type 2 Diabetes Mellitus.
2023
Current microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Composition, Their Interactions, and Metagenome Function in US Adults with Type 2 Diabetes According to Enterotypes.
2023
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the gut virome are associated with type 2 diabetes and diabetic nephropathy.
2023
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome profile of Chinese hypertension patients with and without type 2 diabetes mellitus.
2023
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Functional alterations and predictive capacity of gut microbiome in type 2 diabetes.
2023
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A study on the association between gut microbiota, inflammation, and type 2 diabetes.
2024
Applied microbiology and biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mapping multi-omics characteristics related to short-term PM2.5 trajectory and their impact on type 2 diabetes in middle-aged and elderly adults in Southern China.
2024
Journal of hazardous materials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides uniformis Ameliorates Carbohydrate and Lipid Metabolism Disorders in Diabetic Mice by Regulating Bile Acid Metabolism via the Gut-Liver Axis.
2024
Pharmaceuticals (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota composition and type 2 diabetes: Are these subjects linked Together?
2024
Heliyon
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and obesity in late adolescence: A case-control study in "Children of 1997" birth cohort.
2025
Annals of epidemiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identifying fecal microbiota signatures of colorectal cancer in a Vietnamese cohort.
2024
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal Microbiota Composition in Patients with Type 2 Diabetes and Effects of Oral Antidiabetics.
2025
Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-mediated branched-chain amino acid metabolism: A novel mechanism by which Bacteroides uniformis improves type 2 diabetes mellitus.
2026
Diabetes, obesity & metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Structure-function relationship of Konjac glucomannan with varying acetylation degrees in modulating gut microbiota and alleviating prediabetes.
2026
Carbohydrate polymers
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Systemic and gut microbiome changes with metformin and liraglutide in youth-onset type 2 diabetes: the MIGHTY study.
2025
Gut microbes
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

17 papers
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.
2008
Diabetes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human gut microbes impact host serum metabolome and insulin sensitivity.
2016
Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
2018
Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
2020
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterisation of gut microbiota of obesity and type 2 diabetes in a rodent model.
2021
Bioscience of microbiota, food and health
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome signatures distinguish type 2 diabetes mellitus from non-alcoholic fatty liver disease.
2021
Computational and structural biotechnology journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shenqi compound ameliorates type-2 diabetes mellitus by modulating the gut microbiota and metabolites.
2022
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass.
2022
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Snapshot into the Type-2-Diabetes-Associated Microbiome of a Romanian Cohort.
2022
International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes.
2023
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin.
2023
NPJ biofilms and microbiomes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Canagliflozin alters the gut, oral, and ocular surface microbiota of patients with type 2 diabetes mellitus.
2023
Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative Binding Study of Gliptins to Bacterial DPP4-like Enzymes for the Treatment of Type 2 Diabetes Mellitus (T2DM).
2024
International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis.
2024
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial.
2025
Nature microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bile-processed Rhizoma Coptidis alleviates type 2 diabetes mellitus through modulating the gut microbiota and short-chain fatty acid metabolism.
2025
International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiome.
2025
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

9 papers
Role of gut microbiota in type 2 diabetes pathophysiology.
2020
EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Effects of Metformin on the Gut Microbiota in Obesity and Type 2 Diabetes Mellitus.
2020
Diabetes, metabolic syndrome and obesity : targets and therapy
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022
Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and physical exercise in obesity and diabetes - A systematic review.
2022
Nutrition, metabolism, and cardiovascular diseases : NMCD
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Bi-Directional Interactions between Glucose-Lowering Medications and Gut Microbiome in Patients with Type 2 Diabetes Mellitus: A Systematic Review.
2023
Genes
Relevant review or meta-analysis for the signal-disease area.
Type-2 Diabetes Mellitus and the Gut Microbiota: Systematic Review.
2023
Cureus
Relevant review or meta-analysis for the signal-disease area.
Polysaccharides in Medicinal and Food Homologous Plants regulate intestinal flora to improve type 2 diabetes: Systematic review.
2024
Phytomedicine : international journal of phytotherapy and phytopharmacology
Relevant review or meta-analysis for the signal-disease area.
A systematic review on gut microbiota in type 2 diabetes mellitus.
2024
Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.