sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Bacteroides uniformis
obesity
Bacteroides uniformis looks like a credible signal in obesity, though some caution is still warranted.
Bacteroides uniformis shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
bacteroides_uniformis
Credibility score
96
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 96Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
29 papersBariatric surgery drives major rearrangements of the intestinal microbiota including the biofilm composition.
2018Frontiers in bioscience (Elite edition)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women.
2018Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism.
2020Science advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants.
2020Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome.
2020Molecular metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota alterations reveal potential gut-brain axis changes in polycystic ovary syndrome.
2021Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.
2021Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice.
2021Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome.
2021Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota in people with obesity.
2021PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamic Alteration of the Gut Microbiota Associated with Obesity and Intestinal Inflammation in Ovariectomy C57BL/6 Mice.
2022International journal of endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predictive Role of Gut Microbiota in Weight Loss Achievement after Bariatric Surgery.
2022Journal of the American College of Surgeons
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C).
2022European journal of pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotypes in asthenospermia patients with obesity.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.
2023Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Virulence Factors of the Gut Microbiome Are Associated with BMI and Metabolic Blood Parameters in Children with Obesity.
2023Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Liver Bacterial Colonization in Patients with Obesity and Gut Dysbiosis.
2024Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Temporal variations in the gut microbial diversity in response to high-fat diet and exercise.
2024Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides uniformis CECT 7771 requires adaptive immunity to improve glucose tolerance but not to prevent body weight gain in diet-induced obese mice.
2024Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.
2024Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and obesity in late adolescence: A case-control study in "Children of 1997" birth cohort.
2025Annals of epidemiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
MAGs-based genomic comparison of gut significantly enriched microbes in obese individuals pre- and post-bariatric surgery across diverse locations.
2025Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sex-Specific Effect of a High-Energy Diet on Body Composition, Gut Microbiota, and Inflammatory Markers in Rats.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulation of Gut Microbiota by Whole Encapsulated Brown Seaweed (Himanthalia elongata) in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Trial.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiota composition and cardiometabolic parameters in healthy adults.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in microbiota associated with the use of intragastric balloons.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
29 papersBacteroides uniformis CECT 7771 ameliorates metabolic and immunological dysfunction in mice with high-fat-diet induced obesity.
2012PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
2015Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Safety Assessment of Bacteroides uniformis CECT 7771 Isolated from Stools of Healthy Breast-Fed Infants.
2016PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
2016Cell
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of the Dietary Protein and Carbohydrate Ratio on Gut Microbiomes in Dogs of Different Body Conditions.
2017mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.
2017Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides.
2017Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antibiotic-Induced Alterations in Gut Microbiota Are Associated with Changes in Glucose Metabolism in Healthy Mice.
2017Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
2018Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice.
2019Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis.
2020Liver international : official journal of the International Association for the Study of the Liver
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.
2020The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fubrick tea attenuates high-fat diet induced fat deposition and metabolic disorder by regulating gut microbiota and caffeine metabolism.
2020Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A metagenome-wide association study of gut microbiome and visceral fat accumulation.
2020Computational and structural biotechnology journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice.
2021Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.
2021Cell metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Amelioration of Hepatic Steatosis in Mice through Bacteroides uniformis CBA7346-Mediated Regulation of High-Fat Diet-Induced Insulin Resistance and Lipogenesis.
2021Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The interplay between PCOS pathology and diet on gut microbiota in a mouse model.
2022Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism.
2022Nature metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anti-obesity activity of human gut microbiota Bacteroides stercoris KGMB02265.
2023Archives of microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet.
2024European journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of the gut microbiome and Firmicutes phylum reduction by a nutraceutical blend in the obesity mouse model and overweight humans: A double-blind clinical trial.
2024Food science & nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
2024Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.
2024Proceedings of the National Academy of Sciences of the United States of America
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.
2024Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Synergistic effects of human-origin novel postbiotic Bacteroides & Phocaeicola on obesity and thermogenesis in high-fat diet-induced metabolic dysfunction.
2025Beneficial microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of gut microbiota in Tirzepatide-mediated alleviation of high-fat diet-induced obesity.
2025European journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The effect of short-term consumption of Bifidobacterium bifidum on the gut microbiome of obese individuals.
2026Experimental biology and medicine (Maywood, N.J.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
4-Hydroxyphenanthrene exacerbates obesity by altering gut microbiota and bile acid metabolism.
2026Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
17 papersHost-bacterial mutualism in the human intestine.
2005Science (New York, N.Y.)
Relevant review or meta-analysis for the signal-disease area.
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
2018European journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Diet and microbiota linked in health and disease.
2018Food & function
Relevant review or meta-analysis for the signal-disease area.
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review.
2018Childhood obesity (Print)
Relevant review or meta-analysis for the signal-disease area.
Microbial enterotypes in personalized nutrition and obesity management.
2018The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota-Brain Axis in Pathophysiology of ADHD: A Systematic Review.
2022Journal of attention disorders
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and physical exercise in obesity and diabetes - A systematic review.
2022Nutrition, metabolism, and cardiovascular diseases : NMCD
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives.
2023International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer.
2023Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Relevant review or meta-analysis for the signal-disease area.
Can prebiotics help tackle the childhood obesity epidemic?
2023Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
The Effects of the Mediterranean Diet on Health and Gut Microbiota.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift.
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Impact of vaginal seeding on the gut microbiome of infants born via cesarean section: A systematic review.
2024The Journal of infection
Relevant review or meta-analysis for the signal-disease area.
Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.