Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Bacteroides uniformis
autism
Bacteroides uniformis is an interesting but still moderate-confidence signal in autism.
Bacteroides uniformis shows a strong literature footprint in autism, with substantial central evidence and broader supporting literature.
bacteroides_uniformis
Credibility score
56
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
3/5
Credibility 56Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Primary central evidence
17 papersChanges in the Gut Microbiota of Children with Autism Spectrum Disorder.
2020Autism research : official journal of the International Society for Autism Research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota changes in patients with autism spectrum disorders.
2020Journal of psychiatric research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment.
2021Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota in Korean Children with Autism Spectrum Disorders.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evidence for long-lasting alterations in the fecal microbiota following prenatal alcohol exposure.
2022Alcoholism, clinical and experimental research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The fecal microbiota from children with autism impact gut metabolism and learning and memory abilities of honeybees.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Importance of Nutrigenetics and Microbiota in Personalized Medicine: From Phenotype to Genotype.
2024Cureus
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of Gut Bacterial and Fungal Microbiota in Children with Autism Spectrum Disorder and Their Non-Autistic Siblings.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Efficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial.
2024Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study.
2024Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.
2025Autism research : official journal of the International Society for Autism Research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome differences in children with Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder and effects of probiotic supplementation: A randomized controlled trial.
2025Research in developmental disabilities
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Synbiotics of encapsulated Limosilactobacillus fermentum K73 promotes in vitro favorable gut microbiota shifts and enhances short-chain fatty acid production in fecal samples of children with autism spectrum disorder.
2025Food research international (Ottawa, Ont.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comprehensive analysis of gut microbiota and fecal metabolites in patients with autism spectrum disorder.
2025Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Age-Dependent Gut Microbiome Dysbiosis in Autism Spectrum Disorder and the Role of Key Bacterial Ratios.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
13 papersMicrobiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.
2013Cell
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/- mouse model of ASD-like behavior.
2022Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles.
2023Nature neuroscience
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacteroides is increased in an autism cohort and induces autism-relevant behavioral changes in mice in a sex-dependent manner.
2023NPJ biofilms and microbiomes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome and metabolic profiles of mouse model for MeCP2 duplication syndrome.
2024Brain research bulletin
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B6 metabolism.
2024mSystems
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterization of gut microbiota on gender and age groups bias in Thai patients with autism spectrum disorder.
2025Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of gut microbiota in modulating brain structure and psychiatric disorders: A Mendelian randomization study.
2025NeuroImage
Disease-relevant preclinical or model-based paper useful as supporting evidence.
3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota analysis in children with autism spectrum disorder and their family members.
2025Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacterial genomic structural variations in children with autism serve as diagnostic biomarkers.
2026Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome composition and strain-sharing in multiplex autism spectrum disorder families.
2026Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
10 papersAltered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review.
2019Translational psychiatry
Relevant review or meta-analysis for the signal-disease area.
Can we reduce autism-related gastrointestinal and behavior problems by gut microbiota based dietary modulation? A review.
2021Nutritional neuroscience
Relevant review or meta-analysis for the signal-disease area.
Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
2019Frontiers in psychiatry
Relevant review or meta-analysis for the signal-disease area.
Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
2020Nutrients
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Neuropsychiatric Diseases - Creation of An Atlas-Based on Quantified Evidence.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Exercise Changes Gut Microbiota: A New Idea to Explain that Exercise Improves Autism.
2023International journal of sports medicine
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
2023Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Genus-Level Analysis of Gut Microbiota in Children with Autism Spectrum Disorder: A Mini Review.
2023Children (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Functional contribution of the intestinal microbiome in autism spectrum disorder, attention deficit hyperactivity disorder, and Rett syndrome: a systematic review of pediatric and adult studies.
2024Frontiers in neuroscience
Relevant review or meta-analysis for the signal-disease area.